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Ezetimibe response

MedGen UID:
334236
Concept ID:
C1842722
Finding
Synonyms: EZETIMIBE, NONRESPONSE TO
Drug:
Ezetimibe
MedGen UID:
256233
Concept ID:
C1142985
Pharmacologic Substance
An azetidine derivative and ANTICHOLESTEREMIC AGENT that inhibits intestinal STEROL absorption. It is used to reduce total CHOLESTEROL; LDL CHOLESTEROL, and APOLIPOPROTEINS B in the treatment of HYPERLIPIDEMIAS.
 
OMIM®: 608010

Professional guidelines

Recent clinical studies

Etiology

Tsujita K, Sugiyama S, Sumida H, Shimomura H, Yamashita T, Yamanaga K, Komura N, Sakamoto K, Oka H, Nakao K, Nakamura S, Ishihara M, Matsui K, Sakaino N, Nakamura N, Yamamoto N, Koide S, Matsumura T, Fujimoto K, Tsunoda R, Morikami Y, Matsuyama K, Oshima S, Kaikita K, Hokimoto S, Ogawa H; PRECISE–IVUS Investigators
J Am Coll Cardiol 2015 Aug 4;66(5):495-507. doi: 10.1016/j.jacc.2015.05.065. PMID: 26227186
Saeedi R, Johns K, Frohlich J, Bennett MT, Bondy G
Lipids Health Dis 2015 Jun 19;14:57. doi: 10.1186/s12944-015-0054-x. [Epub ahead of print] PMID: 26087958Free PMC Article
Descamps O, Tomassini JE, Lin J, Polis AB, Shah A, Brudi P, Hanson ME, Tershakovec AM
Atherosclerosis 2015 Jun;240(2):482-9. Epub 2015 Mar 9 doi: 10.1016/j.atherosclerosis.2015.03.004. [Epub ahead of print] PMID: 25913444
Ambegaonkar BM, Tipping D, Polis AB, Tomassini JE, Tershakovec AM
Atherosclerosis 2014 Dec;237(2):829-37. Epub 2014 Nov 4 doi: 10.1016/j.atherosclerosis.2014.10.105. [Epub ahead of print] PMID: 25463129
Lu L, Krumholz HM, Tu JV, Ross JS, Ko DT, Jackevicius CA
Circ Cardiovasc Qual Outcomes 2014 Jul;7(4):589-96. Epub 2014 Jun 3 doi: 10.1161/CIRCOUTCOMES.114.001023. [Epub ahead of print] PMID: 24895451Free PMC Article

Diagnosis

Tsujita K, Sugiyama S, Sumida H, Shimomura H, Yamashita T, Yamanaga K, Komura N, Sakamoto K, Oka H, Nakao K, Nakamura S, Ishihara M, Matsui K, Sakaino N, Nakamura N, Yamamoto N, Koide S, Matsumura T, Fujimoto K, Tsunoda R, Morikami Y, Matsuyama K, Oshima S, Kaikita K, Hokimoto S, Ogawa H; PRECISE–IVUS Investigators
J Am Coll Cardiol 2015 Aug 4;66(5):495-507. doi: 10.1016/j.jacc.2015.05.065. PMID: 26227186
Saeedi R, Johns K, Frohlich J, Bennett MT, Bondy G
Lipids Health Dis 2015 Jun 19;14:57. doi: 10.1186/s12944-015-0054-x. [Epub ahead of print] PMID: 26087958Free PMC Article
Descamps O, Tomassini JE, Lin J, Polis AB, Shah A, Brudi P, Hanson ME, Tershakovec AM
Atherosclerosis 2015 Jun;240(2):482-9. Epub 2015 Mar 9 doi: 10.1016/j.atherosclerosis.2015.03.004. [Epub ahead of print] PMID: 25913444
Kusters DM, Caceres M, Coll M, Cuffie C, Gagné C, Jacobson MS, Kwiterovich PO, Lee R, Lowe RS, Massaad R, McCrindle BW, Musliner TA, Triscari J, Kastelein JJ
J Pediatr 2015 Jun;166(6):1377-84.e1-3. Epub 2015 Apr 1 doi: 10.1016/j.jpeds.2015.02.043. [Epub ahead of print] PMID: 25841542
Leyes P, Martínez E, Larrousse M, Cofán M, Trabal J, Pérez-Heras AM, Forga MT, Ros E
BMC Infect Dis 2014 Sep 11;14:497. doi: 10.1186/1471-2334-14-497. [Epub ahead of print] PMID: 25209653Free PMC Article

Therapy

Tsujita K, Sugiyama S, Sumida H, Shimomura H, Yamashita T, Yamanaga K, Komura N, Sakamoto K, Oka H, Nakao K, Nakamura S, Ishihara M, Matsui K, Sakaino N, Nakamura N, Yamamoto N, Koide S, Matsumura T, Fujimoto K, Tsunoda R, Morikami Y, Matsuyama K, Oshima S, Kaikita K, Hokimoto S, Ogawa H; PRECISE–IVUS Investigators
J Am Coll Cardiol 2015 Aug 4;66(5):495-507. doi: 10.1016/j.jacc.2015.05.065. PMID: 26227186
Saeedi R, Johns K, Frohlich J, Bennett MT, Bondy G
Lipids Health Dis 2015 Jun 19;14:57. doi: 10.1186/s12944-015-0054-x. [Epub ahead of print] PMID: 26087958Free PMC Article
Descamps O, Tomassini JE, Lin J, Polis AB, Shah A, Brudi P, Hanson ME, Tershakovec AM
Atherosclerosis 2015 Jun;240(2):482-9. Epub 2015 Mar 9 doi: 10.1016/j.atherosclerosis.2015.03.004. [Epub ahead of print] PMID: 25913444
Loomba R, Sirlin CB, Ang B, Bettencourt R, Jain R, Salotti J, Soaft L, Hooker J, Kono Y, Bhatt A, Hernandez L, Nguyen P, Noureddin M, Haufe W, Hooker C, Yin M, Ehman R, Lin GY, Valasek MA, Brenner DA, Richards L; San Diego Integrated NAFLD Research Consortium (SINC)
Hepatology 2015 Apr;61(4):1239-50. Epub 2015 Feb 27 doi: 10.1002/hep.27647. [Epub ahead of print] PMID: 25482832Free PMC Article
Bays HE, Chen E, Tomassini JE, McPeters G, Polis AB, Triscari J
Fundam Clin Pharmacol 2015 Apr;29(2):209-18. Epub 2015 Feb 27 doi: 10.1111/fcp.12096. [Epub ahead of print] PMID: 25431239

Prognosis

Bays HE, Chen E, Tomassini JE, McPeters G, Polis AB, Triscari J
Fundam Clin Pharmacol 2015 Apr;29(2):209-18. Epub 2015 Feb 27 doi: 10.1111/fcp.12096. [Epub ahead of print] PMID: 25431239
Chiba T, Sakurada T, Watanabe R, Yamaguchi K, Kimura Y, Kioka N, Kawagishi H, Matsuo M, Ueda K
PLoS One 2014;9(12):e116162. Epub 2014 Dec 31 doi: 10.1371/journal.pone.0116162. PMID: 25551765Free PMC Article
Leyes P, Martínez E, Larrousse M, Cofán M, Trabal J, Pérez-Heras AM, Forga MT, Ros E
BMC Infect Dis 2014 Sep 11;14:497. doi: 10.1186/1471-2334-14-497. [Epub ahead of print] PMID: 25209653Free PMC Article
Lu L, Krumholz HM, Tu JV, Ross JS, Ko DT, Jackevicius CA
Circ Cardiovasc Qual Outcomes 2014 Jul;7(4):589-96. Epub 2014 Jun 3 doi: 10.1161/CIRCOUTCOMES.114.001023. [Epub ahead of print] PMID: 24895451Free PMC Article
Lu L, Krumholz HM, Tu JV, Ross JS, Ko DT, Jackevicius CA
Am Heart J 2014 May;167(5):683-9. Epub 2014 Feb 26 doi: 10.1016/j.ahj.2014.01.014. [Epub ahead of print] PMID: 24766978Free PMC Article

Clinical prediction guides

Saeedi R, Johns K, Frohlich J, Bennett MT, Bondy G
Lipids Health Dis 2015 Jun 19;14:57. doi: 10.1186/s12944-015-0054-x. [Epub ahead of print] PMID: 26087958Free PMC Article
Li L, Zhang M, Su F, Li Y, Shen Y, Shen J, Zhang D
Lipids Health Dis 2015 Feb 18;14:10. doi: 10.1186/s12944-015-0004-7. [Epub ahead of print] PMID: 25879728Free PMC Article
Zambrano T, Saavedra N, Lanas F, Caamaño J, Salazar LA
Mol Diagn Ther 2015 Feb;19(1):45-52. doi: 10.1007/s40291-014-0128-x. PMID: 25589339
Bays HE, Chen E, Tomassini JE, McPeters G, Polis AB, Triscari J
Fundam Clin Pharmacol 2015 Apr;29(2):209-18. Epub 2015 Feb 27 doi: 10.1111/fcp.12096. [Epub ahead of print] PMID: 25431239
Chiba T, Sakurada T, Watanabe R, Yamaguchi K, Kimura Y, Kioka N, Kawagishi H, Matsuo M, Ueda K
PLoS One 2014;9(12):e116162. Epub 2014 Dec 31 doi: 10.1371/journal.pone.0116162. PMID: 25551765Free PMC Article

Recent systematic reviews

Descamps O, Tomassini JE, Lin J, Polis AB, Shah A, Brudi P, Hanson ME, Tershakovec AM
Atherosclerosis 2015 Jun;240(2):482-9. Epub 2015 Mar 9 doi: 10.1016/j.atherosclerosis.2015.03.004. [Epub ahead of print] PMID: 25913444
Kim S, Chen MH, Ibrahim JG, Shah AK, Lin J
Stat Med 2013 Oct 15;32(23):3972-90. Epub 2013 Apr 12 doi: 10.1002/sim.5814. [Epub ahead of print] PMID: 23580436Free PMC Article
Morrone D, Weintraub WS, Toth PP, Hanson ME, Lowe RS, Lin J, Shah AK, Tershakovec AM
Atherosclerosis 2012 Aug;223(2):251-61. Epub 2012 Feb 16 doi: 10.1016/j.atherosclerosis.2012.02.016. [Epub ahead of print] PMID: 22410123
Abramson BL, Benlian P, Hanson ME, Lin J, Shah A, Tershakovec AM
Lipids Health Dis 2011 Aug 22;10:146. doi: 10.1186/1476-511X-10-146. [Epub ahead of print] PMID: 21859459Free PMC Article
Descamps OS, De Sutter J, Guillaume M, Missault L
Atherosclerosis 2011 Aug;217(2):308-21. Epub 2011 Jun 12 doi: 10.1016/j.atherosclerosis.2011.06.010. [Epub ahead of print] PMID: 21762916

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