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Autism 6(AUTS6)

MedGen UID:
324472
Concept ID:
C1836271
Disease or Syndrome
Synonyms: AUTISM, SUSCEPTIBILITY TO, 6; AUTS6
 
OMIM: 609378

Definition

Autism, the prototypic pervasive developmental disorder (PDD), is usually apparent by 3 years of age. It is characterized by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypic, and ritualized patterns of interests and behavior (Bailey et al., 1996; Risch et al., 1999). 'Autism spectrum disorder,' sometimes referred to as ASD, is a broader phenotype encompassing the less severe disorders Asperger syndrome (see ASPG1; 608638) and pervasive developmental disorder, not otherwise specified (PDD-NOS). 'Broad autism phenotype' includes individuals with some symptoms of autism, but who do not meet the full criteria for autism or other disorders. Mental retardation coexists in approximately two-thirds of individuals with ASD, except for Asperger syndrome, in which mental retardation is conspicuously absent (Jones et al., 2008). Genetic studies in autism often include family members with these less stringent diagnoses (Schellenberg et al., 2006). For a discussion of genetic heterogeneity of autism, see 209850. [from OMIM]

Recent clinical studies

Etiology

Gunnes N, Surén P, Bresnahan M, Hornig M, Lie KK, Lipkin WI, Magnus P, Nilsen RM, Reichborn-Kjennerud T, Schjølberg S, Susser ES, Øyen AS, Stoltenberg C
Epidemiology 2013 Nov;24(6):906-12. doi: 10.1097/01.ede.0000434435.52506.f5. PMID: 24045716
Ghaleiha A, Mohammadi E, Mohammadi MR, Farokhnia M, Modabbernia A, Yekehtaz H, Ashrafi M, Hassanzadeh E, Akhondzadeh S
Paediatr Drugs 2013 Dec;15(6):505-14. doi: 10.1007/s40272-013-0036-2. PMID: 23821414
Rosman NP, Bergia BM
J Child Neurol 2013 Dec;28(12):1587-98. Epub 2013 Jan 22 doi: 10.1177/0883073812472391. [Epub ahead of print] PMID: 23340080
Ghaleiha A, Asadabadi M, Mohammadi MR, Shahei M, Tabrizi M, Hajiaghaee R, Hassanzadeh E, Akhondzadeh S
Int J Neuropsychopharmacol 2013 May;16(4):783-9. Epub 2012 Sep 24 doi: 10.1017/S1461145712000880. [Epub ahead of print] PMID: 22999292
Georgiades S, Szatmari P, Zwaigenbaum L, Bryson S, Brian J, Roberts W, Smith I, Vaillancourt T, Roncadin C, Garon N
JAMA Psychiatry 2013 Jan;70(1):42-8. doi: 10.1001/2013.jamapsychiatry.1. PMID: 22945359

Diagnosis

Findling RL, Mankoski R, Timko K, Lears K, McCartney T, McQuade RD, Eudicone JM, Amatniek J, Marcus RN, Sheehan JJ
J Clin Psychiatry 2014 Jan;75(1):22-30. doi: 10.4088/JCP.13m8500. PMID: 24502859
Ghaleiha A, Mohammadi E, Mohammadi MR, Farokhnia M, Modabbernia A, Yekehtaz H, Ashrafi M, Hassanzadeh E, Akhondzadeh S
Paediatr Drugs 2013 Dec;15(6):505-14. doi: 10.1007/s40272-013-0036-2. PMID: 23821414
Rosman NP, Bergia BM
J Child Neurol 2013 Dec;28(12):1587-98. Epub 2013 Jan 22 doi: 10.1177/0883073812472391. [Epub ahead of print] PMID: 23340080
Georgiades S, Szatmari P, Zwaigenbaum L, Bryson S, Brian J, Roberts W, Smith I, Vaillancourt T, Roncadin C, Garon N
JAMA Psychiatry 2013 Jan;70(1):42-8. doi: 10.1001/2013.jamapsychiatry.1. PMID: 22945359
Tordjman S, Anderson GM, Bellissant E, Botbol M, Charbuy H, Camus F, Graignic R, Kermarrec S, Fougerou C, Cohen D, Touitou Y
Psychoneuroendocrinology 2012 Dec;37(12):1990-7. Epub 2012 May 19 doi: 10.1016/j.psyneuen.2012.04.013. [Epub ahead of print] PMID: 22613035

Therapy

Findling RL, Mankoski R, Timko K, Lears K, McCartney T, McQuade RD, Eudicone JM, Amatniek J, Marcus RN, Sheehan JJ
J Clin Psychiatry 2014 Jan;75(1):22-30. doi: 10.4088/JCP.13m8500. PMID: 24502859
Mankoski R, Stockton G, Manos G, Marler S, McQuade R, Forbes RA, Marcus R
J Child Adolesc Psychopharmacol 2013 Oct;23(8):572-6. doi: 10.1089/cap.2012.0075. PMID: 24138011Free PMC Article
Ghaleiha A, Mohammadi E, Mohammadi MR, Farokhnia M, Modabbernia A, Yekehtaz H, Ashrafi M, Hassanzadeh E, Akhondzadeh S
Paediatr Drugs 2013 Dec;15(6):505-14. doi: 10.1007/s40272-013-0036-2. PMID: 23821414
Ghaleiha A, Asadabadi M, Mohammadi MR, Shahei M, Tabrizi M, Hajiaghaee R, Hassanzadeh E, Akhondzadeh S
Int J Neuropsychopharmacol 2013 May;16(4):783-9. Epub 2012 Sep 24 doi: 10.1017/S1461145712000880. [Epub ahead of print] PMID: 22999292
Georgiades S, Szatmari P, Zwaigenbaum L, Bryson S, Brian J, Roberts W, Smith I, Vaillancourt T, Roncadin C, Garon N
JAMA Psychiatry 2013 Jan;70(1):42-8. doi: 10.1001/2013.jamapsychiatry.1. PMID: 22945359

Prognosis

Mankoski R, Stockton G, Manos G, Marler S, McQuade R, Forbes RA, Marcus R
J Child Adolesc Psychopharmacol 2013 Oct;23(8):572-6. doi: 10.1089/cap.2012.0075. PMID: 24138011Free PMC Article
Mostafa GA, Al-Ayadhi LY
J Neuroimmunol 2013 Aug 15;261(1-2):77-81. Epub 2013 May 29 doi: 10.1016/j.jneuroim.2013.04.003. [Epub ahead of print] PMID: 23726766
Rosman NP, Bergia BM
J Child Neurol 2013 Dec;28(12):1587-98. Epub 2013 Jan 22 doi: 10.1177/0883073812472391. [Epub ahead of print] PMID: 23340080
Asadabadi M, Mohammadi MR, Ghanizadeh A, Modabbernia A, Ashrafi M, Hassanzadeh E, Forghani S, Akhondzadeh S
Psychopharmacology (Berl) 2013 Jan;225(1):51-9. Epub 2012 Jul 11 doi: 10.1007/s00213-012-2796-8. [Epub ahead of print] PMID: 22782459
Mordre M, Groholt B, Knudsen AK, Sponheim E, Mykletun A, Myhre AM
J Autism Dev Disord 2012 Jun;42(6):920-8. doi: 10.1007/s10803-011-1319-5. PMID: 21713590Free PMC Article

Clinical prediction guides

Findling RL, Mankoski R, Timko K, Lears K, McCartney T, McQuade RD, Eudicone JM, Amatniek J, Marcus RN, Sheehan JJ
J Clin Psychiatry 2014 Jan;75(1):22-30. doi: 10.4088/JCP.13m8500. PMID: 24502859
Ghaleiha A, Mohammadi E, Mohammadi MR, Farokhnia M, Modabbernia A, Yekehtaz H, Ashrafi M, Hassanzadeh E, Akhondzadeh S
Paediatr Drugs 2013 Dec;15(6):505-14. doi: 10.1007/s40272-013-0036-2. PMID: 23821414
Rosman NP, Bergia BM
J Child Neurol 2013 Dec;28(12):1587-98. Epub 2013 Jan 22 doi: 10.1177/0883073812472391. [Epub ahead of print] PMID: 23340080
Ghaleiha A, Asadabadi M, Mohammadi MR, Shahei M, Tabrizi M, Hajiaghaee R, Hassanzadeh E, Akhondzadeh S
Int J Neuropsychopharmacol 2013 May;16(4):783-9. Epub 2012 Sep 24 doi: 10.1017/S1461145712000880. [Epub ahead of print] PMID: 22999292
Tordjman S, Anderson GM, Bellissant E, Botbol M, Charbuy H, Camus F, Graignic R, Kermarrec S, Fougerou C, Cohen D, Touitou Y
Psychoneuroendocrinology 2012 Dec;37(12):1990-7. Epub 2012 May 19 doi: 10.1016/j.psyneuen.2012.04.013. [Epub ahead of print] PMID: 22613035

Recent systematic reviews

Ghanizadeh A
Dis Markers 2013;35(5):281-6. Epub 2013 Sep 12 doi: 10.1155/2013/536521. PMID: 24167375Free PMC Article
Sunita, Bilszta JL
J Paediatr Child Health 2013 Jun;49(6):438-44. Epub 2012 Sep 12 doi: 10.1111/j.1440-1754.2012.02558.x. [Epub ahead of print] PMID: 22971004
Barger BD, Campbell JM, McDonough JD
J Autism Dev Disord 2013 Apr;43(4):817-28. doi: 10.1007/s10803-012-1621-x. PMID: 22855372
Alcantara J, Alcantara JD, Alcantara J
Explore (NY) 2011 Nov-Dec;7(6):384-90. doi: 10.1016/j.explore.2011.08.001. PMID: 22051563
Yu KK, Cheung C, Chua SE, McAlonan GM
J Psychiatry Neurosci 2011 Nov;36(6):412-21. doi: 10.1503/jpn.100138. PMID: 21406158Free PMC Article

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