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Longevity 1

MedGen UID:
412999
Concept ID:
C2750617
Disease or Syndrome
Synonyms: LONGEVITY 1
 
Cytogenetic location: 4q25
OMIM®: 152430

Definition

Longevity, or extended life span, is a complex trait, determined by multiple genes as well as by environmental factors. Longevity has been associated with a locus on chromosome 4 (LGV1). Longevity has also been associated with a locus on chromosome 6q21 (LGV2; 606460). See also 502000 for a discussion of aging related to changes in mitochondrial DNA. [from OMIM]

Recent clinical studies

Etiology

Gentilini D, Mari D, Castaldi D, Remondini D, Ogliari G, Ostan R, Bucci L, Sirchia SM, Tabano S, Cavagnini F, Monti D, Franceschi C, Di Blasio AM, Vitale G
Age (Dordr) 2013 Oct;35(5):1961-73. Epub 2012 Aug 25 doi: 10.1007/s11357-012-9463-1. [Epub ahead of print] PMID: 22923132Free PMC Article
Stark J
Pediatr Cardiol 1998 Jul-Aug;19(4):282-8. PMID: 9636251
McGlone FB, Kick E
J Am Geriatr Soc 1978 Nov;26(11):481-8. PMID: 701699

Diagnosis

Simpson EL, Duenas A, Holmes MW, Papaioannou D, Chilcott J
Health Technol Assess 2009 Mar;13(17):iii, ix-x, 1-154. doi: 10.3310/hta13170. PMID: 19331797

Therapy

Simpson EL, Duenas A, Holmes MW, Papaioannou D, Chilcott J
Health Technol Assess 2009 Mar;13(17):iii, ix-x, 1-154. doi: 10.3310/hta13170. PMID: 19331797

Prognosis

Gentilini D, Mari D, Castaldi D, Remondini D, Ogliari G, Ostan R, Bucci L, Sirchia SM, Tabano S, Cavagnini F, Monti D, Franceschi C, Di Blasio AM, Vitale G
Age (Dordr) 2013 Oct;35(5):1961-73. Epub 2012 Aug 25 doi: 10.1007/s11357-012-9463-1. [Epub ahead of print] PMID: 22923132Free PMC Article
Stark J
Pediatr Cardiol 1998 Jul-Aug;19(4):282-8. PMID: 9636251

Clinical prediction guides

Gentilini D, Mari D, Castaldi D, Remondini D, Ogliari G, Ostan R, Bucci L, Sirchia SM, Tabano S, Cavagnini F, Monti D, Franceschi C, Di Blasio AM, Vitale G
Age (Dordr) 2013 Oct;35(5):1961-73. Epub 2012 Aug 25 doi: 10.1007/s11357-012-9463-1. [Epub ahead of print] PMID: 22923132Free PMC Article
Stark J
Pediatr Cardiol 1998 Jul-Aug;19(4):282-8. PMID: 9636251

Recent systematic reviews

Simpson EL, Duenas A, Holmes MW, Papaioannou D, Chilcott J
Health Technol Assess 2009 Mar;13(17):iii, ix-x, 1-154. doi: 10.3310/hta13170. PMID: 19331797

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