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Migraine(MA)

MedGen UID:
57451
Concept ID:
C0149931
Disease or Syndrome
Synonyms: Migraine Disorders; MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).
SNOMED CT: Migraine (37796009)
 
Genes: TNF; ESR1; EDNRA
Cytogenetic locations: 6p21.33; 6q25.1-25.2
OMIM®: 157300

Definition

Migraine is the most common type of chronic, episodic headache, as summarized by Featherstone (1985). One locus for migraine with or without aura (MGR1) has been identified on chromosome 4q24. Other loci for migraine have been identified on 6p21.1-p12.2 (MGR3; 607498), 14q21.2-q22.3 (MGR4; 607501), 19p13 (MGR5; 607508), 1q31 (MGR6; 607516), 15q11-q13 (MGR7; 609179), 5q21 (with or without aura, MGR8, 609570; with aura, MGR9, 609670), 17p13 (MGR10; 610208), 18q12 (MGR11; 610209), 10q22-q23 (MGR12; 611706), and the X chromosome (MGR2; 300125). Mutation in the KCNK18 gene (613655) on chromosome 10q25 causes migraine with aura (MGR13; 613656). A subtype of autosomal dominant migraine with aura (MA), familial hemiplegic migraine (FHM; see 141500), is caused by mutation in the CACNA1A gene (601011) on chromosome 19p13 (FHM1; 141500), by mutation in the ATP1A2 gene (182340) on chromosome 1q21 (FHM2; 602481), or by mutation in the SCN1A gene (182389) on chromosome 2q24 (FHM3; 609634). Another locus for FHM has been mapped to chromosome 1q31 (FHM4; see 607516). There is evidence that a polymorphism in the estrogen receptor gene (ESR1; 133430.0005) and a polymorphism in the TNF gene (191160.0004) may confer susceptibility to migraine. A polymorphism in the endothelin receptor type A gene (EDNRA; 131243.0001) may confer resistance to migraine. [from OMIM]

Clinical features

Photophobia
MedGen UID:
504524
Concept ID:
CN000575
Finding
Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light.
Photophobia
MedGen UID:
504524
Concept ID:
CN000575
Finding
Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light.
Migraine with aura
MedGen UID:
505086
Concept ID:
CN001879
Finding
A type of migraine in which there is an aura characterized by focal neurological phenomena that usually proceed, but may accompany or occur in the absence of, the headache. The symptoms of an aura may include fully reversible visual, sensory, and speech symptoms but not motor weakness. Visual symptoms may include flickering lights, spots and lines and/or loss of vision and/or unilateral sensory symptoms such as paresthesias or numbness. At least one of the symptoms of an aura develops gradually over 5 or more minutes and/or different symptoms occur in succession.
Migraine without aura
MedGen UID:
505090
Concept ID:
CN001884
Finding
Repeated headache attacks lasting 4-72 h fulfilling at least two of the following criteria: 1) unilateral location, 2) pulsating quality, 3) moderate or severe pain intensity, and 4) aggravation by or causing avoidance of routine physical activity such as climbing stairs. Headache attacks are commonly accompanied by nausea, vomiting, photophobia, or phonophobia.
Phonophobia
MedGen UID:
505146
Concept ID:
CN001979
Finding
An abnormally heightened sensitivity to loud sounds.
Nausea
MedGen UID:
368427
Concept ID:
C1963179
Pathologic Function
Vomiting
MedGen UID:
776588
Concept ID:
C2712332
Finding

Recent clinical studies

Etiology

Winter AC, Rice MS, Fortner RT, Eliassen AH, Kurth T, Tamimi RM
J Natl Cancer Inst 2015 Jan;107(1):381. Epub 2014 Dec 12 doi: 10.1093/jnci/dju381. PMID: 25505231Free PMC Article
Molavi S, Zwiebel S, Gittleman H, Alleyne B, Guyuron B
Plast Reconstr Surg 2014 Dec;134(6):1306-11. doi: 10.1097/PRS.0000000000000728. PMID: 25415096
Silberstein S, Patel S
Expert Opin Pharmacother 2014 Oct;15(14):2063-70. Epub 2014 Aug 6 doi: 10.1517/14656566.2014.947959. [Epub ahead of print] PMID: 25100506
Chiossi L, Negro A, Capi M, Lionetto L, Martelletti P
Expert Opin Pharmacother 2014 Aug;15(12):1697-706. Epub 2014 Jun 18 doi: 10.1517/14656566.2014.929665. [Epub ahead of print] PMID: 24941134
DeConde AS, Mace JC, Smith TL
Laryngoscope 2014 Aug;124(8):1750-5. Epub 2014 Feb 20 doi: 10.1002/lary.24592. [Epub ahead of print] PMID: 24431279Free PMC Article

Diagnosis

Winter AC, Rice MS, Fortner RT, Eliassen AH, Kurth T, Tamimi RM
J Natl Cancer Inst 2015 Jan;107(1):381. Epub 2014 Dec 12 doi: 10.1093/jnci/dju381. PMID: 25505231Free PMC Article
Whitcup SM, Turkel CC, DeGryse RE, Brin MF
Ann N Y Acad Sci 2014 Nov;1329:67-80. Epub 2014 Aug 18 doi: 10.1111/nyas.12488. [Epub ahead of print] PMID: 25399521
Dodick DW, Goadsby PJ, Silberstein SD, Lipton RB, Olesen J, Ashina M, Wilks K, Kudrow D, Kroll R, Kohrman B, Bargar R, Hirman J, Smith J; ALD403 study investigators
Lancet Neurol 2014 Nov;13(11):1100-7. Epub 2014 Oct 5 doi: 10.1016/S1474-4422(14)70209-1. [Epub ahead of print] PMID: 25297013
Chiossi L, Negro A, Capi M, Lionetto L, Martelletti P
Expert Opin Pharmacother 2014 Aug;15(12):1697-706. Epub 2014 Jun 18 doi: 10.1517/14656566.2014.929665. [Epub ahead of print] PMID: 24941134
Cosentino G, Fierro B, Vigneri S, Talamanca S, Paladino P, Baschi R, Indovino S, Maccora S, Valentino F, Fileccia E, Giglia G, Brighina F
Pain 2014 Jun;155(6):1070-8. Epub 2014 Mar 13 doi: 10.1016/j.pain.2014.02.024. [Epub ahead of print] PMID: 24631596

Therapy

Whitcup SM, Turkel CC, DeGryse RE, Brin MF
Ann N Y Acad Sci 2014 Nov;1329:67-80. Epub 2014 Aug 18 doi: 10.1111/nyas.12488. [Epub ahead of print] PMID: 25399521
Guo S, Olesen J, Ashina M
Brain 2014 Nov;137(Pt 11):2951-9. Epub 2014 Aug 26 doi: 10.1093/brain/awu244. [Epub ahead of print] PMID: 25161294
Silberstein S, Patel S
Expert Opin Pharmacother 2014 Oct;15(14):2063-70. Epub 2014 Aug 6 doi: 10.1517/14656566.2014.947959. [Epub ahead of print] PMID: 25100506
Silberstein SD, Stirpe JC
Expert Opin Pharmacother 2014 Sep;15(13):1863-74. Epub 2014 Jul 10 doi: 10.1517/14656566.2014.937704. [Epub ahead of print] PMID: 25010639
Chiossi L, Negro A, Capi M, Lionetto L, Martelletti P
Expert Opin Pharmacother 2014 Aug;15(12):1697-706. Epub 2014 Jun 18 doi: 10.1517/14656566.2014.929665. [Epub ahead of print] PMID: 24941134

Prognosis

Winter AC, Rice MS, Fortner RT, Eliassen AH, Kurth T, Tamimi RM
J Natl Cancer Inst 2015 Jan;107(1):381. Epub 2014 Dec 12 doi: 10.1093/jnci/dju381. PMID: 25505231Free PMC Article
Molavi S, Zwiebel S, Gittleman H, Alleyne B, Guyuron B
Plast Reconstr Surg 2014 Dec;134(6):1306-11. doi: 10.1097/PRS.0000000000000728. PMID: 25415096
Wang YC, Lin CW, Ho YT, Huang YP, Pan SL
Int J Cardiol 2014 Mar 1;172(1):213-6. Epub 2014 Jan 15 doi: 10.1016/j.ijcard.2014.01.005. [Epub ahead of print] PMID: 24462142
Roldan CJ
J Emerg Med 2014 Mar;46(3):420-7. Epub 2013 Sep 26 doi: 10.1016/j.jemermed.2013.08.019. [Epub ahead of print] PMID: 24074526
Moisset X, Ouchchane L, Guy N, Bayle DJ, Dallel R, Clavelou P
Pain 2013 Dec;154(12):2691-9. Epub 2013 Aug 2 doi: 10.1016/j.pain.2013.07.050. [Epub ahead of print] PMID: 23911697

Clinical prediction guides

Molavi S, Zwiebel S, Gittleman H, Alleyne B, Guyuron B
Plast Reconstr Surg 2014 Dec;134(6):1306-11. doi: 10.1097/PRS.0000000000000728. PMID: 25415096
Ho TW, Connor KM, Zhang Y, Pearlman E, Koppenhaver J, Fan X, Lines C, Edvinsson L, Goadsby PJ, Michelson D
Neurology 2014 Sep 9;83(11):958-66. Epub 2014 Aug 8 doi: 10.1212/WNL.0000000000000771. [Epub ahead of print] PMID: 25107879
Monteith T, Gardener H, Rundek T, Dong C, Yoshita M, Elkind MS, DeCarli C, Sacco RL, Wright CB
Stroke 2014 Jun;45(6):1830-2. Epub 2014 May 15 doi: 10.1161/STROKEAHA.114.005447. [Epub ahead of print] PMID: 24876263Free PMC Article
Cosentino G, Fierro B, Vigneri S, Talamanca S, Paladino P, Baschi R, Indovino S, Maccora S, Valentino F, Fileccia E, Giglia G, Brighina F
Pain 2014 Jun;155(6):1070-8. Epub 2014 Mar 13 doi: 10.1016/j.pain.2014.02.024. [Epub ahead of print] PMID: 24631596
DeConde AS, Mace JC, Smith TL
Laryngoscope 2014 Aug;124(8):1750-5. Epub 2014 Feb 20 doi: 10.1002/lary.24592. [Epub ahead of print] PMID: 24431279Free PMC Article

Recent systematic reviews

Winter AC, Rice MS, Fortner RT, Eliassen AH, Kurth T, Tamimi RM
J Natl Cancer Inst 2015 Jan;107(1):381. Epub 2014 Dec 12 doi: 10.1093/jnci/dju381. PMID: 25505231Free PMC Article
Chai NC, Peterlin BL, Calhoun AH
Curr Opin Neurol 2014 Jun;27(3):315-24. doi: 10.1097/WCO.0000000000000091. PMID: 24792340Free PMC Article
Schankin CJ, Maniyar FH, Digre KB, Goadsby PJ
Brain 2014 May;137(Pt 5):1419-28. Epub 2014 Mar 18 doi: 10.1093/brain/awu050. [Epub ahead of print] PMID: 24645145
Lip PZ, Lip GY
Am J Med 2014 May;127(5):411-20. Epub 2013 Dec 17 doi: 10.1016/j.amjmed.2013.12.006. [Epub ahead of print] PMID: 24355354
Thorlund K, Mills EJ, Wu P, Ramos E, Chatterjee A, Druyts E, Goadsby PJ
Cephalalgia 2014 Apr;34(4):258-67. Epub 2013 Oct 9 doi: 10.1177/0333102413508661. [Epub ahead of print] PMID: 24108308

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