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Schizophrenia 10(SCZD10)

MedGen UID:
107776
Concept ID:
C0543918
Mental or Behavioral Dysfunction
Synonyms: CATATONIA, PERIODIC; SCHIZOPHRENIA SUSCEPTIBILITY LOCUS, CHROMOSOME 15q15-RELATED; SCZD10
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).
 
OMIM: 605419

Clinical features

Disturbance of facial expression
MedGen UID:
505797
Concept ID:
CN004725
Finding
An abnormality of the gestures or movements executed with the facial muscles with which emotions such as fear, joy, sadness, surprise, and disgust can be expressed.
Delusions
MedGen UID:
504582
Concept ID:
CN000702
Finding
A belief that is pathological and is held despite evidence to the contrary.

Recent clinical studies

Etiology

Dickinson D, Straub RE, Trampush JW, Gao Y, Feng N, Xie B, Shin JH, Lim HK, Ursini G, Bigos KL, Kolachana B, Hashimoto R, Takeda M, Baum GL, Rujescu D, Callicott JH, Hyde TM, Berman KF, Kleinman JE, Weinberger DR
JAMA Psychiatry 2014 Jun;71(6):647-56. doi: 10.1001/jamapsychiatry.2014.157. PMID: 24718902
Bilic P, Jukic V, Vilibic M, Savic A, Bozina N
Gene 2014 Jun 10;543(1):125-32. Epub 2014 Mar 27 doi: 10.1016/j.gene.2014.03.050. [Epub ahead of print] PMID: 24680725
Sweeting J, Duflou J, Semsarian C
Schizophr Res 2013 Nov;150(2-3):398-403. Epub 2013 Sep 9 doi: 10.1016/j.schres.2013.08.029. [Epub ahead of print] PMID: 24028743
Tay YH, Nurjono M, Lee J
Schizophr Res 2013 Jun;147(1):187-92. Epub 2013 Apr 13 doi: 10.1016/j.schres.2013.03.023. [Epub ahead of print] PMID: 23590873
Bai YM, Su TP, Chen MH, Chen TJ, Chang WH
J Affect Disord 2013 Aug 15;150(1):57-62. Epub 2013 Mar 16 doi: 10.1016/j.jad.2013.02.019. [Epub ahead of print] PMID: 23510547

Diagnosis

Umbricht D, Alberati D, Martin-Facklam M, Borroni E, Youssef EA, Ostland M, Wallace TL, Knoflach F, Dorflinger E, Wettstein JG, Bausch A, Garibaldi G, Santarelli L
JAMA Psychiatry 2014 Jun;71(6):637-46. doi: 10.1001/jamapsychiatry.2014.163. PMID: 24696094
Bilic P, Jukic V, Vilibic M, Savic A, Bozina N
Gene 2014 Jun 10;543(1):125-32. Epub 2014 Mar 27 doi: 10.1016/j.gene.2014.03.050. [Epub ahead of print] PMID: 24680725
Kredentser MS, Martens PJ, Chochinov HM, Prior HJ
J Clin Psychiatry 2014 Feb;75(2):154-61. doi: 10.4088/JCP.13m08711. PMID: 24602251
Sweeting J, Duflou J, Semsarian C
Schizophr Res 2013 Nov;150(2-3):398-403. Epub 2013 Sep 9 doi: 10.1016/j.schres.2013.08.029. [Epub ahead of print] PMID: 24028743
Bai YM, Su TP, Chen MH, Chen TJ, Chang WH
J Affect Disord 2013 Aug 15;150(1):57-62. Epub 2013 Mar 16 doi: 10.1016/j.jad.2013.02.019. [Epub ahead of print] PMID: 23510547

Therapy

Umbricht D, Alberati D, Martin-Facklam M, Borroni E, Youssef EA, Ostland M, Wallace TL, Knoflach F, Dorflinger E, Wettstein JG, Bausch A, Garibaldi G, Santarelli L
JAMA Psychiatry 2014 Jun;71(6):637-46. doi: 10.1001/jamapsychiatry.2014.163. PMID: 24696094
Bilic P, Jukic V, Vilibic M, Savic A, Bozina N
Gene 2014 Jun 10;543(1):125-32. Epub 2014 Mar 27 doi: 10.1016/j.gene.2014.03.050. [Epub ahead of print] PMID: 24680725
Sprooten E, Papmeyer M, Smyth AM, Vincenz D, Honold S, Conlon GA, Moorhead TW, Job D, Whalley HC, Hall J, McIntosh AM, Owens DC, Johnstone EC, Lawrie SM
Schizophr Res 2013 Dec;151(1-3):259-64. Epub 2013 Oct 10 doi: 10.1016/j.schres.2013.09.024. [Epub ahead of print] PMID: 24120958
Brain C, Allerby K, Sameby B, Quinlan P, Joas E, Karilampi U, Lindström E, Eberhard J, Burns T, Waern M
Eur Neuropsychopharmacol 2013 Dec;23(12):1754-62. Epub 2013 Sep 19 doi: 10.1016/j.euroneuro.2013.09.001. [Epub ahead of print] PMID: 24091164
da Silva Alves F, Bakker G, Schmitz N, Abeling N, Hasler G, van der Meer J, Nederveen A, de Haan L, Linszen D, van Amelsvoort T
Eur Neuropsychopharmacol 2013 Nov;23(11):1577-86. Epub 2013 Aug 24 doi: 10.1016/j.euroneuro.2013.06.008. [Epub ahead of print] PMID: 23978392

Prognosis

Umbricht D, Alberati D, Martin-Facklam M, Borroni E, Youssef EA, Ostland M, Wallace TL, Knoflach F, Dorflinger E, Wettstein JG, Bausch A, Garibaldi G, Santarelli L
JAMA Psychiatry 2014 Jun;71(6):637-46. doi: 10.1001/jamapsychiatry.2014.163. PMID: 24696094
Tsai KY, Chung TC, Lee CC, Chou YM, Su CY, Shen SP, Lin CH, Chou FH
Soc Psychiatry Psychiatr Epidemiol 2014 Jan;49(1):89-96. Epub 2013 Jun 2 doi: 10.1007/s00127-013-0716-9. [Epub ahead of print] PMID: 23728232
Sweeting J, Duflou J, Semsarian C
Schizophr Res 2013 Nov;150(2-3):398-403. Epub 2013 Sep 9 doi: 10.1016/j.schres.2013.08.029. [Epub ahead of print] PMID: 24028743
Tay YH, Nurjono M, Lee J
Schizophr Res 2013 Jun;147(1):187-92. Epub 2013 Apr 13 doi: 10.1016/j.schres.2013.03.023. [Epub ahead of print] PMID: 23590873
Bai YM, Su TP, Chen MH, Chen TJ, Chang WH
J Affect Disord 2013 Aug 15;150(1):57-62. Epub 2013 Mar 16 doi: 10.1016/j.jad.2013.02.019. [Epub ahead of print] PMID: 23510547

Clinical prediction guides

Umbricht D, Alberati D, Martin-Facklam M, Borroni E, Youssef EA, Ostland M, Wallace TL, Knoflach F, Dorflinger E, Wettstein JG, Bausch A, Garibaldi G, Santarelli L
JAMA Psychiatry 2014 Jun;71(6):637-46. doi: 10.1001/jamapsychiatry.2014.163. PMID: 24696094
Matsuo K, Chen SH, Liu CM, Liu CC, Hwang TJ, Hsieh MH, Chien YL, Hwu HG, Tseng WY
Schizophr Res 2013 Dec;151(1-3):133-40. Epub 2013 Nov 18 doi: 10.1016/j.schres.2013.10.028. [Epub ahead of print] PMID: 24262681
Dimitrov DH, Lee S, Yantis J, Valdez C, Paredes RM, Braida N, Velligan D, Walss-Bass C
Schizophr Res 2013 Dec;151(1-3):29-35. Epub 2013 Nov 5 doi: 10.1016/j.schres.2013.10.019. [Epub ahead of print] PMID: 24210870
Brain C, Allerby K, Sameby B, Quinlan P, Joas E, Karilampi U, Lindström E, Eberhard J, Burns T, Waern M
Eur Neuropsychopharmacol 2013 Dec;23(12):1754-62. Epub 2013 Sep 19 doi: 10.1016/j.euroneuro.2013.09.001. [Epub ahead of print] PMID: 24091164
Tay YH, Nurjono M, Lee J
Schizophr Res 2013 Jun;147(1):187-92. Epub 2013 Apr 13 doi: 10.1016/j.schres.2013.03.023. [Epub ahead of print] PMID: 23590873

Recent systematic reviews

Koch K, Mansi K, Haynes E, Adams CE, Sampson S, Furtado VA
Cochrane Database Syst Rev 2014 Jan 11;1:CD010226. doi: 10.1002/14651858.CD010226.pub2. PMID: 24414883
Khanna P, Suo T, Komossa K, Ma H, Rummel-Kluge C, El-Sayeh HG, Leucht S, Xia J
Cochrane Database Syst Rev 2014 Jan 2;1:CD006569. doi: 10.1002/14651858.CD006569.pub5. PMID: 24385408
van der Werf M, Hanssen M, Köhler S, Verkaaik M, Verhey FR; RISE Investigators, van Winkel R, van Os J, Allardyce J
Psychol Med 2014 Jan;44(1):9-16. Epub 2012 Dec 17 doi: 10.1017/S0033291712002796. [Epub ahead of print] PMID: 23244442
Adams CE, Bergman H, Irving CB, Lawrie S
Cochrane Database Syst Rev 2013 Nov 15;11:CD003082. doi: 10.1002/14651858.CD003082.pub3. PMID: 24242360
Dold M, Li C, Gillies D, Leucht S
Eur Neuropsychopharmacol 2013 Sep;23(9):1023-33. Epub 2013 Apr 17 doi: 10.1016/j.euroneuro.2013.03.001. [Epub ahead of print] PMID: 23602690

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