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Pleomorphic adenoma of salivary gland

MedGen UID:
275400
Concept ID:
C1519176
Neoplastic Process
Synonyms: Salivary gland adenoma, pleomorphic
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).
SNOMED CT: Pleomorphic adenoma of salivary gland (447888006)
 
Gene: PLAG1
Cytogenetic location: 8q12.1
OMIM®: 181030

Definition

A benign, slow-growing tumor composed of cells that demonstrate both epithelial and mesenchymal differentiation. It is the most common neoplasm of salivary gland origin, and mostly occurs in the parotid gland. The average age of patients has been reported to be 43 years; women are more often affected than men. The malignant change rate has been estimated to be 6%. The malignant counterpart is carcinoma ex pleomorphic adenoma. --2003 [from NCI]

Clinical features

Neoplasm
MedGen UID:
227011
Concept ID:
C1306459
Finding
A malignant tumor at the original site of growth.

Recent clinical studies

Etiology

Skálová A, Vanecek T, Simpson RH, Vazmitsel MA, Majewska H, Mukensnabl P, Hauer L, Andrle P, Hosticka L, Grossmann P, Michal M
Am J Surg Pathol 2013 Nov;37(11):1743-50. doi: 10.1097/PAS.0000000000000065. PMID: 24121173
Zhao J, Wang J, Yu C, Guo L, Wang K, Liang Z, Lou J
World J Surg Oncol 2013 Aug 8;11(1):180. doi: 10.1186/1477-7819-11-180. [Epub ahead of print] PMID: 23924064Free PMC Article
Al-Khtoum N, Qubilat AR, Al-Zaidaneen S, Al Mefleh S, Al-Qudah A
J Pak Med Assoc 2013 Mar;63(3):358-60. PMID: 23914638
Heaton CM, Chazen JL, van Zante A, Glastonbury CM, Kezirian EJ, Eisele DW
Laryngoscope 2013 Dec;123(12):3056-60. Epub 2013 Jun 21 doi: 10.1002/lary.24247. [Epub ahead of print] PMID: 23798340
Fu H, Wang J, Wang L, Zhang Z, He Y
J Pediatr Surg 2012 Apr;47(4):715-9. doi: 10.1016/j.jpedsurg.2011.10.067. PMID: 22498386

Diagnosis

Faur AC, Lazar E, Cornianu M
APMIS 2014 May;122(5):418-26. Epub 2013 Aug 13 doi: 10.1111/apm.12160. [Epub ahead of print] PMID: 23937241
Sharma A, Deshmukh S, Shaikh A, Dabholkar J
Singapore Med J 2013 Sep;54(9):e183-4. PMID: 24068067
Zhao J, Wang J, Yu C, Guo L, Wang K, Liang Z, Lou J
World J Surg Oncol 2013 Aug 8;11(1):180. doi: 10.1186/1477-7819-11-180. [Epub ahead of print] PMID: 23924064Free PMC Article
Al-Khtoum N, Qubilat AR, Al-Zaidaneen S, Al Mefleh S, Al-Qudah A
J Pak Med Assoc 2013 Mar;63(3):358-60. PMID: 23914638
Heaton CM, Chazen JL, van Zante A, Glastonbury CM, Kezirian EJ, Eisele DW
Laryngoscope 2013 Dec;123(12):3056-60. Epub 2013 Jun 21 doi: 10.1002/lary.24247. [Epub ahead of print] PMID: 23798340

Therapy

Cimino-Mathews A, Lin BM, Chang SS, Boahene KD, Bishop JA
Head Neck Pathol 2012 Dec;6(4):502-6. Epub 2012 Jun 27 doi: 10.1007/s12105-012-0376-1. [Epub ahead of print] PMID: 22736150Free PMC Article
Bahrami A, Dalton JD, Krane JF, Fletcher CD
Genes Chromosomes Cancer 2012 Feb;51(2):140-8. Epub 2011 Oct 28 doi: 10.1002/gcc.20938. [Epub ahead of print] PMID: 22038920Free PMC Article
Emodi O, El-Naaj IA, Gordin A, Akrish S, Peled M
J Oral Maxillofac Surg 2010 Sep;68(9):2092-8. Epub 2010 Jun 17 doi: 10.1016/j.joms.2009.09.075. [Epub ahead of print] PMID: 20728030
Benoit MM, Handzel O, McKenna MJ, Deschler DG
Otol Neurotol 2010 Sep;31(7):1157-9. doi: 10.1097/MAO.0b013e3181ec1b73. PMID: 20657328
Sharon E, Kelly RJ, Szabo E
Head Neck Oncol 2010 May 26;2:12. doi: 10.1186/1758-3284-2-12. [Epub ahead of print] PMID: 20504363Free PMC Article

Prognosis

Faur AC, Lazar E, Cornianu M
APMIS 2014 May;122(5):418-26. Epub 2013 Aug 13 doi: 10.1111/apm.12160. [Epub ahead of print] PMID: 23937241
Skálová A, Vanecek T, Simpson RH, Vazmitsel MA, Majewska H, Mukensnabl P, Hauer L, Andrle P, Hosticka L, Grossmann P, Michal M
Am J Surg Pathol 2013 Nov;37(11):1743-50. doi: 10.1097/PAS.0000000000000065. PMID: 24121173
Zhao J, Wang J, Yu C, Guo L, Wang K, Liang Z, Lou J
World J Surg Oncol 2013 Aug 8;11(1):180. doi: 10.1186/1477-7819-11-180. [Epub ahead of print] PMID: 23924064Free PMC Article
Heaton CM, Chazen JL, van Zante A, Glastonbury CM, Kezirian EJ, Eisele DW
Laryngoscope 2013 Dec;123(12):3056-60. Epub 2013 Jun 21 doi: 10.1002/lary.24247. [Epub ahead of print] PMID: 23798340
Fu H, Wang J, Wang L, Zhang Z, He Y
J Pediatr Surg 2012 Apr;47(4):715-9. doi: 10.1016/j.jpedsurg.2011.10.067. PMID: 22498386

Clinical prediction guides

von Holstein SL, Fehr A, Persson M, Nickelsen M, Therkildsen MH, Prause JU, Heegaard S, Stenman G
Ophthalmology 2014 May;121(5):1125-33. Epub 2014 Jan 24 doi: 10.1016/j.ophtha.2013.11.037. [Epub ahead of print] PMID: 24468654
Pusztaszeri MP, Sadow PM, Ushiku A, Bordignon P, McKee TA, Faquin WC
Cancer Cytopathol 2014 Apr;122(4):257-65. Epub 2013 Dec 2 doi: 10.1002/cncy.21381. [Epub ahead of print] PMID: 24302647
Fok TC, Lapointe H, Tuck AB, Chambers AF, Jackson-Boeters L, Daley TD, Darling MR
Oral Surg Oral Med Oral Pathol Oral Radiol 2013 Dec;116(6):743-51. doi: 10.1016/j.oooo.2013.09.004. PMID: 24237725
Heaton CM, Chazen JL, van Zante A, Glastonbury CM, Kezirian EJ, Eisele DW
Laryngoscope 2013 Dec;123(12):3056-60. Epub 2013 Jun 21 doi: 10.1002/lary.24247. [Epub ahead of print] PMID: 23798340
Darling MR, Hashem NN, Zhang I, Mohamed AB, Fung K, Kwan K, Mara TW, Daley TD, Diamandis EP
Int J Biol Markers 2012 Dec 27;27(4):e381-8. doi: 10.5301/JBM.2012.10373. PMID: 23250777

Recent systematic reviews

McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928
Taki NH, Laver N, Quinto T, Wein RO
Head Neck 2013 May;35(5):E161-3. Epub 2012 Feb 6 doi: 10.1002/hed.22900. [Epub ahead of print] PMID: 22307836
Carino S, Cabrini RL
Acta Odontol Latinoam 2007;20(1):23-31. PMID: 18046967
Buchner A, Merrell PW, Carpenter WM
J Oral Pathol Med 2007 Apr;36(4):207-14. doi: 10.1111/j.1600-0714.2007.00522.x. PMID: 17391298
Nouraei SA, Ferguson MS, Clarke PM, Sandison A, Sandhu GS, Michaels L, Rhys-Evans P
Arch Otolaryngol Head Neck Surg 2006 Jul;132(7):788-93. doi: 10.1001/archotol.132.7.788. PMID: 16847191

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