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Skeletal system disorder

MedGen UID:
538042
•Concept ID:
C0263661
•
Disease or Syndrome
Synonym: Skeletal system disease
SNOMED CT: Disease of bone AND/OR joint (88230002); Osteoarthropathy (88230002); Disorder of skeletal system (88230002)
 
Monarch Initiative: MONDO:0005172

Definition

A disease involving the skeletal system. [from MONDO]

Professional guidelines

PubMed

Diagnosis and Management of Multiple Myeloma: A Review.
Cowan AJ, Green DJ, Kwok M, Lee S, Coffey DG, Holmberg LA, Tuazon S, Gopal AK, Libby EN
JAMA 2022 Feb 1;327(5):464-477. doi: 10.1001/jama.2022.0003. PMID: 35103762
Consensus on diagnosis and management of Cushing's disease: a guideline update.
Fleseriu M, Auchus R, Bancos I, Ben-Shlomo A, Bertherat J, Biermasz NR, Boguszewski CL, Bronstein MD, Buchfelder M, Carmichael JD, Casanueva FF, Castinetti F, Chanson P, Findling J, Gadelha M, Geer EB, Giustina A, Grossman A, Gurnell M, Ho K, Ioachimescu AG, Kaiser UB, Karavitaki N, Katznelson L, Kelly DF, Lacroix A, McCormack A, Melmed S, Molitch M, Mortini P, Newell-Price J, Nieman L, Pereira AM, Petersenn S, Pivonello R, Raff H, Reincke M, Salvatori R, Scaroni C, Shimon I, Stratakis CA, Swearingen B, Tabarin A, Takahashi Y, Theodoropoulou M, Tsagarakis S, Valassi E, Varlamov EV, Vila G, Wass J, Webb SM, Zatelli MC, Biller BMK
Lancet Diabetes Endocrinol 2021 Dec;9(12):847-875. Epub 2021 Oct 20 doi: 10.1016/S2213-8587(21)00235-7. PMID: 34687601Free PMC Article
Epidemiology, Staging, and Management of Multiple Myeloma.
Padala SA, Barsouk A, Barsouk A, Rawla P, Vakiti A, Kolhe R, Kota V, Ajebo GH
Med Sci (Basel) 2021 Jan 20;9(1) doi: 10.3390/medsci9010003. PMID: 33498356Free PMC Article

Recent clinical studies

Etiology

Systemic autoinflammatory disease in adults.
Betrains A, Staels F, Schrijvers R, Meyts I, Humblet-Baron S, De Langhe E, Wouters C, Blockmans D, Vanderschueren S
Autoimmun Rev 2021 Apr;20(4):102774. Epub 2021 Feb 17 doi: 10.1016/j.autrev.2021.102774. PMID: 33609798
Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors.
Fiuza-Luces C, Santos-Lozano A, Joyner M, Carrera-Bastos P, Picazo O, Zugaza JL, Izquierdo M, Ruilope LM, Lucia A
Nat Rev Cardiol 2018 Dec;15(12):731-743. doi: 10.1038/s41569-018-0065-1. PMID: 30115967
Cancer-associated cachexia.
Baracos VE, Martin L, Korc M, Guttridge DC, Fearon KCH
Nat Rev Dis Primers 2018 Jan 18;4:17105. doi: 10.1038/nrdp.2017.105. PMID: 29345251
Hypothalamic Amenorrhea and the Long-Term Health Consequences.
Shufelt CL, Torbati T, Dutra E
Semin Reprod Med 2017 May;35(3):256-262. Epub 2017 Jun 28 doi: 10.1055/s-0037-1603581. PMID: 28658709Free PMC Article
Complications of Cushing's syndrome: state of the art.
Pivonello R, Isidori AM, De Martino MC, Newell-Price J, Biller BM, Colao A
Lancet Diabetes Endocrinol 2016 Jul;4(7):611-29. Epub 2016 May 10 doi: 10.1016/S2213-8587(16)00086-3. PMID: 27177728

Diagnosis

Complexity of skeletal muscle degeneration: multi-systems pathophysiology and organ crosstalk in dystrophinopathy.
Ohlendieck K, Swandulla D
Pflugers Arch 2021 Dec;473(12):1813-1839. Epub 2021 Sep 22 doi: 10.1007/s00424-021-02623-1. PMID: 34553265Free PMC Article
Muscle ultrasound: Present state and future opportunities.
Wijntjes J, van Alfen N
Muscle Nerve 2021 Apr;63(4):455-466. Epub 2020 Oct 13 doi: 10.1002/mus.27081. PMID: 33051891Free PMC Article
Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors.
Fiuza-Luces C, Santos-Lozano A, Joyner M, Carrera-Bastos P, Picazo O, Zugaza JL, Izquierdo M, Ruilope LM, Lucia A
Nat Rev Cardiol 2018 Dec;15(12):731-743. doi: 10.1038/s41569-018-0065-1. PMID: 30115967
Biomechanics of the spine. Part I: spinal stability.
Izzo R, Guarnieri G, Guglielmi G, Muto M
Eur J Radiol 2013 Jan;82(1):118-26. Epub 2012 Oct 22 doi: 10.1016/j.ejrad.2012.07.024. PMID: 23088879
A practical approach to hypercalcemia.
Carroll MF, Schade DS
Am Fam Physician 2003 May 1;67(9):1959-66. PMID: 12751658

Therapy

The Application of Creatine Supplementation in Medical Rehabilitation.
Harmon KK, Stout JR, Fukuda DH, Pabian PS, Rawson ES, Stock MS
Nutrients 2021 May 27;13(6) doi: 10.3390/nu13061825. PMID: 34071875Free PMC Article
Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases.
Pedersen BK, Saltin B
Scand J Med Sci Sports 2015 Dec;25 Suppl 3:1-72. doi: 10.1111/sms.12581. PMID: 26606383
Human alcohol-related neuropathology.
de la Monte SM, Kril JJ
Acta Neuropathol 2014 Jan;127(1):71-90. Epub 2013 Dec 27 doi: 10.1007/s00401-013-1233-3. PMID: 24370929Free PMC Article
Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review.
Chou R, Peterson K, Helfand M
J Pain Symptom Manage 2004 Aug;28(2):140-75. doi: 10.1016/j.jpainsymman.2004.05.002. PMID: 15276195
A practical approach to hypercalcemia.
Carroll MF, Schade DS
Am Fam Physician 2003 May 1;67(9):1959-66. PMID: 12751658

Prognosis

Complexity of skeletal muscle degeneration: multi-systems pathophysiology and organ crosstalk in dystrophinopathy.
Ohlendieck K, Swandulla D
Pflugers Arch 2021 Dec;473(12):1813-1839. Epub 2021 Sep 22 doi: 10.1007/s00424-021-02623-1. PMID: 34553265Free PMC Article
Mechanisms of muscle atrophy and hypertrophy: implications in health and disease.
Sartori R, Romanello V, Sandri M
Nat Commun 2021 Jan 12;12(1):330. doi: 10.1038/s41467-020-20123-1. PMID: 33436614Free PMC Article
Predicting scoliosis progression from skeletal maturity: a simplified classification during adolescence.
Sanders JO, Khoury JG, Kishan S, Browne RH, Mooney JF 3rd, Arnold KD, McConnell SJ, Bauman JA, Finegold DN
J Bone Joint Surg Am 2008 Mar;90(3):540-53. doi: 10.2106/JBJS.G.00004. PMID: 18310704
Extrapulmonary tuberculosis: an overview.
Golden MP, Vikram HR
Am Fam Physician 2005 Nov 1;72(9):1761-8. PMID: 16300038
A practical approach to hypercalcemia.
Carroll MF, Schade DS
Am Fam Physician 2003 May 1;67(9):1959-66. PMID: 12751658

Clinical prediction guides

Natural history of Becker muscular dystrophy: a multicenter study of 225 patients.
Nakamura A, Matsumura T, Ogata K, Mori-Yoshimura M, Takeshita E, Kimura K, Kawashima T, Tomo Y, Arahata H, Miyazaki D, Takeshima Y, Takahashi T, Ishigaki K, Kuru S, Wakisaka A, Awano H, Funato M, Sato T, Saito Y, Takada H, Sugie K, Kobayashi M, Ozasa S, Fujii T, Maegaki Y, Oi H, Tachimori H, Komaki H
Ann Clin Transl Neurol 2023 Dec;10(12):2360-2372. Epub 2023 Oct 26 doi: 10.1002/acn3.51925. PMID: 37882106Free PMC Article
Organ Abnormalities Caused by Turner Syndrome.
Yoon SH, Kim GY, Choi GT, Do JT
Cells 2023 May 11;12(10) doi: 10.3390/cells12101365. PMID: 37408200Free PMC Article
Muscle ultrasound: Present state and future opportunities.
Wijntjes J, van Alfen N
Muscle Nerve 2021 Apr;63(4):455-466. Epub 2020 Oct 13 doi: 10.1002/mus.27081. PMID: 33051891Free PMC Article
The CHD4-related syndrome: a comprehensive investigation of the clinical spectrum, genotype-phenotype correlations, and molecular basis.
Weiss K, Lazar HP, Kurolap A, Martinez AF, Paperna T, Cohen L, Smeland MF, Whalen S, Heide S, Keren B, Terhal P, Irving M, Takaku M, Roberts JD, Petrovich RM, Schrier Vergano SA, Kenney A, Hove H, DeChene E, Quinonez SC, Colin E, Ziegler A, Rumple M, Jain M, Monteil D, Roeder ER, Nugent K, van Haeringen A, Gambello M, Santani A, Medne L, Krock B, Skraban CM, Zackai EH, Dubbs HA, Smol T, Ghoumid J, Parker MJ, Wright M, Turnpenny P, Clayton-Smith J, Metcalfe K, Kurumizaka H, Gelb BD, Baris Feldman H, Campeau PM, Muenke M, Wade PA, Lachlan K
Genet Med 2020 Feb;22(2):389-397. Epub 2019 Aug 7 doi: 10.1038/s41436-019-0612-0. PMID: 31388190Free PMC Article
Predicting scoliosis progression from skeletal maturity: a simplified classification during adolescence.
Sanders JO, Khoury JG, Kishan S, Browne RH, Mooney JF 3rd, Arnold KD, McConnell SJ, Bauman JA, Finegold DN
J Bone Joint Surg Am 2008 Mar;90(3):540-53. doi: 10.2106/JBJS.G.00004. PMID: 18310704

Recent systematic reviews

A systematic review and meta-analysis of the prevalence and correlation of mild cognitive impairment in sarcopenia.
Yang Y, Xiao M, Leng L, Jiang S, Feng L, Pan G, Li Z, Wang Y, Wang J, Wen Y, Wu D, Yang Y, Huang P
J Cachexia Sarcopenia Muscle 2023 Feb;14(1):45-56. Epub 2022 Dec 18 doi: 10.1002/jcsm.13143. PMID: 36529141Free PMC Article
Efficacy of synthetic and biological DMARDs: a systematic literature review informing the 2022 update of the EULAR recommendations for the management of rheumatoid arthritis.
Kerschbaumer A, Sepriano A, Bergstra SA, Smolen JS, van der Heijde D, Caporali R, Edwards CJ, Verschueren P, de Souza S, Pope JE, Takeuchi T, Hyrich KL, Winthrop KL, Aletaha D, Stamm TA, Schoones JW, Landewé RBM
Ann Rheum Dis 2023 Jan;82(1):95-106. Epub 2022 Nov 11 doi: 10.1136/ard-2022-223365. PMID: 36368906
Effect of sarcopenia on survival in patients with cirrhosis: A meta-analysis.
Tantai X, Liu Y, Yeo YH, Praktiknjo M, Mauro E, Hamaguchi Y, Engelmann C, Zhang P, Jeong JY, van Vugt JLA, Xiao H, Deng H, Gao X, Ye Q, Zhang J, Yang L, Cai Y, Liu Y, Liu N, Li Z, Han T, Kaido T, Sohn JH, Strassburg C, Berg T, Trebicka J, Hsu YC, IJzermans JNM, Wang J, Su GL, Ji F, Nguyen MH
J Hepatol 2022 Mar;76(3):588-599. Epub 2021 Nov 14 doi: 10.1016/j.jhep.2021.11.006. PMID: 34785325
Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency.
Morris AA, Kožich V, Santra S, Andria G, Ben-Omran TI, Chakrapani AB, Crushell E, Henderson MJ, Hochuli M, Huemer M, Janssen MC, Maillot F, Mayne PD, McNulty J, Morrison TM, Ogier H, O'Sullivan S, Pavlíková M, de Almeida IT, Terry A, Yap S, Blom HJ, Chapman KA
J Inherit Metab Dis 2017 Jan;40(1):49-74. Epub 2016 Oct 24 doi: 10.1007/s10545-016-9979-0. PMID: 27778219Free PMC Article
Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review.
Chou R, Peterson K, Helfand M
J Pain Symptom Manage 2004 Aug;28(2):140-75. doi: 10.1016/j.jpainsymman.2004.05.002. PMID: 15276195

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