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Mucinosis

MedGen UID:
56520
Concept ID:
C0162855
Disease or Syndrome
Synonyms: Mucinoses
SNOMED CT: Mucinosis (11528001)
 

Definition

Mucoid states characterized by the elevated deposition and accumulation of mucin (mucopolysaccharides) in dermal tissue. The fibroblasts are responsible for the production of acid mucopolysaccharides (GLYCOSAMINOGLYCANS) in the ground substance of the connective tissue system. When fibroblasts produce abnormally large quantities of mucopolysaccharides as hyaluronic acid, chondroitin sulfate, or heparin, they accumulate in large amounts in the dermis. [from MeSH]

Recent clinical studies

Etiology

Neto JR, Sendyk M, Uchida LM, Nunes FD, de Paiva JB
Am J Orthod Dentofacial Orthop 2014 Apr;145(4):534-8. doi: 10.1016/j.ajodo.2013.02.035. PMID: 24703292
Favarato MH, Miranda SS, Caleiro MT, Assad AP, Halpern I, Fuller R
An Bras Dermatol 2013 Jul-Aug;88(4):635-8. doi: 10.1590/abd1806-4841.20131948. PMID: 24068142Free PMC Article
Alikhan A, Griffin J, Nguyen N, Davis DM, Gibson LE
Pediatr Dermatol 2013 Mar-Apr;30(2):192-8. Epub 2012 Dec 28 doi: 10.1111/pde.12019. [Epub ahead of print] PMID: 23278316
Thareja S, Paghdal K, Lien MH, Fenske NA
Int J Dermatol 2012 Aug;51(8):903-9. doi: 10.1111/j.1365-4632.2011.05292.x. PMID: 22788804
Zvulunov A, Shkalim V, Ben-Amitai D, Feinmesser M
J Am Acad Dermatol 2012 Dec;67(6):1174-81. Epub 2012 May 10 doi: 10.1016/j.jaad.2012.04.015. [Epub ahead of print] PMID: 22579407

Diagnosis

Neto JR, Sendyk M, Uchida LM, Nunes FD, de Paiva JB
Am J Orthod Dentofacial Orthop 2014 Apr;145(4):534-8. doi: 10.1016/j.ajodo.2013.02.035. PMID: 24703292
Missall TA, Hurley MY, Burkemper NM
J Cutan Pathol 2013 Oct;40(10):887-90. Epub 2013 Aug 21 doi: 10.1111/cup.12201. [Epub ahead of print] PMID: 23962142
Yaman B, Gerçeker Türk B, Öztürk G, Ertam I, Kandıloğlu G, Akalin T
Turk Patoloji Derg 2013;29(2):108-16. doi: 10.5146/tjpath.2013.01160. PMID: 23661347
Alikhan A, Griffin J, Nguyen N, Davis DM, Gibson LE
Pediatr Dermatol 2013 Mar-Apr;30(2):192-8. Epub 2012 Dec 28 doi: 10.1111/pde.12019. [Epub ahead of print] PMID: 23278316
Blakey BL, Gratrix ML
Cutis 2012 Jun;89(6):266-8. PMID: 22838088

Therapy

Neto JR, Sendyk M, Uchida LM, Nunes FD, de Paiva JB
Am J Orthod Dentofacial Orthop 2014 Apr;145(4):534-8. doi: 10.1016/j.ajodo.2013.02.035. PMID: 24703292
Missall TA, Hurley MY, Burkemper NM
J Cutan Pathol 2013 Oct;40(10):887-90. Epub 2013 Aug 21 doi: 10.1111/cup.12201. [Epub ahead of print] PMID: 23962142
Shalin SC, Brantley J, Diwan AH
J Cutan Pathol 2012 Nov;39(11):1022-5. Epub 2012 Aug 10 doi: 10.1111/j.1600-0560.2012.01980.x. [Epub ahead of print] PMID: 22882386
Thareja S, Paghdal K, Lien MH, Fenske NA
Int J Dermatol 2012 Aug;51(8):903-9. doi: 10.1111/j.1365-4632.2011.05292.x. PMID: 22788804
Cheng S, Leach IH, Perkins W
Clin Exp Dermatol 2011 Aug;36(6):635-7. Epub 2011 May 17 doi: 10.1111/j.1365-2230.2011.04036.x. [Epub ahead of print] PMID: 21575038

Prognosis

Neto JR, Sendyk M, Uchida LM, Nunes FD, de Paiva JB
Am J Orthod Dentofacial Orthop 2014 Apr;145(4):534-8. doi: 10.1016/j.ajodo.2013.02.035. PMID: 24703292
Yaman B, Gerçeker Türk B, Öztürk G, Ertam I, Kandıloğlu G, Akalin T
Turk Patoloji Derg 2013;29(2):108-16. doi: 10.5146/tjpath.2013.01160. PMID: 23661347
Alikhan A, Griffin J, Nguyen N, Davis DM, Gibson LE
Pediatr Dermatol 2013 Mar-Apr;30(2):192-8. Epub 2012 Dec 28 doi: 10.1111/pde.12019. [Epub ahead of print] PMID: 23278316
Barreau M, Dompmartin-Blanchère A, Jamous R, Chababi M, Soutou B, Reynier-Rezzi J, Laplaud AL, Acher A, Rod J, Jeanne-Pasquier C, Fraitag S
Am J Dermatopathol 2012 Oct;34(7):699-705. doi: 10.1097/DAD.0b013e3182459345. PMID: 22481495
Mir M, Jogi R, Rosen T
Cutis 2011 Dec;88(6):300-2. PMID: 22372171

Clinical prediction guides

Missall TA, Hurley MY, Burkemper NM
J Cutan Pathol 2013 Oct;40(10):887-90. Epub 2013 Aug 21 doi: 10.1111/cup.12201. [Epub ahead of print] PMID: 23962142
Yaman B, Gerçeker Türk B, Öztürk G, Ertam I, Kandıloğlu G, Akalin T
Turk Patoloji Derg 2013;29(2):108-16. doi: 10.5146/tjpath.2013.01160. PMID: 23661347
Wriston CC, Rubin AI, Martin LK, Kossard S, Murrell DF
Am J Dermatopathol 2012 Jun;34(4):e50-4. doi: 10.1097/DAD.0b013e3181f87e91. PMID: 22617136
Zvulunov A, Shkalim V, Ben-Amitai D, Feinmesser M
J Am Acad Dermatol 2012 Dec;67(6):1174-81. Epub 2012 May 10 doi: 10.1016/j.jaad.2012.04.015. [Epub ahead of print] PMID: 22579407
Wang P, Yang H, Ran Y
Arch Dermatol 2011 May;147(5):599-602. doi: 10.1001/archdermatol.2011.110. PMID: 21576580

Recent systematic reviews

Wheeler BR, Reddy SK, Kenwright D, Keating JP
N Z Med J 2014 Feb 14;127(1389):31-9. PMID: 24548955
Erceg A, de Jong EM, van de Kerkhof PC, Seyger MM
J Am Acad Dermatol 2013 Oct;69(4):609-615.e8. Epub 2013 May 24 doi: 10.1016/j.jaad.2013.03.029. [Epub ahead of print] PMID: 23711766
Alikhan A, Griffin J, Nguyen N, Davis DM, Gibson LE
Pediatr Dermatol 2013 Mar-Apr;30(2):192-8. Epub 2012 Dec 28 doi: 10.1111/pde.12019. [Epub ahead of print] PMID: 23278316
Lehman JS, Cook-Norris RH, Weed BR, Weenig RH, Gibson LE, Weaver AL, Pittelkow MR
Arch Dermatol 2010 Jun;146(6):607-13. doi: 10.1001/archdermatol.2010.101. PMID: 20566923
Brodell LA, Beck LA
Ann Allergy Asthma Immunol 2008 Mar;100(3):181-8; quiz 188-90, 215. doi: 10.1016/S1081-1206(10)60438-3. PMID: 18426134

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