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Results: 9

1.

danaparoid

MedGen UID:
75445
Concept ID:
C0259507
Pharmacologic Substance
2.

Stroke

A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810) [from MeSH]

MedGen UID:
52522
Concept ID:
C0038454
Disease or Syndrome
3.

Org 10172

MedGen UID:
19103
Concept ID:
C0069610
Pharmacologic Substance
4.

Ischemic stroke

MedGen UID:
505123
Concept ID:
CN001939
Finding
5.

Stroke

MedGen UID:
340407
Concept ID:
C1849743
Finding
6.

Ischemic stroke

A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. It is said to be the third leading cause of death in the United States. Gunel and Lifton (1996) noted that about 20% of strokes are hemorrhagic, resulting in bleeding into the brain. Ischemic strokes, resulting from vascular occlusion, account for the majority of strokes. Bersano et al. (2008) reviewed genetic polymorphisms that have been implicated in the development of stroke. Candidate genes include those involved in hemostasis (see, e.g., F5; 612309), the renin-angiotensin-aldosterone system (see, e.g., ACE; 106180), homocysteine (see, e.g., MTHFR; 607093), and lipoprotein metabolism (see, e.g., APOE; 107741). See also hemorrhagic stroke, or intracerebral hemorrhage (ICH; 614519). [from OMIM]

MedGen UID:
215292
Concept ID:
C0948008
Disease or Syndrome
7.

Heparinoids

Heparin derivatives. The term has also been used more loosely to include naturally occurring and synthetic highly-sulphated polysaccharides of similar structure. Heparinoid preparations have been used for a wide range of applications including as anticoagulants and anti-inflammatories and they have been claimed to have hypolipidemic properties. (From Martindale, The Extra Pharmacopoeia, 30th, p232) [from MeSH]

MedGen UID:
9216
Concept ID:
C0019142
Pharmacologic Substance
8.

Atheroid

MedGen UID:
2113
Concept ID:
C0004148
Pharmacologic Substance
9.

Danaparoid sodium

The sodium salt form of danaparoid, a synthetic low molecular weight heparin (LMWH) derived from porcine gut mucosa with anticoagulant activity. Danaparoid sodium binds to antithrombin III and inhibits the activity of activated factor X (factor Xa) and, to a lesser extent, activated factor II (thrombin) thereby preventing fibrin formation. Compared to heparin, danaparoid sodium exhibits a much higher ratio of anti-factor Xa activity to anti-factor IIa activity (22:1). [from NCI]

MedGen UID:
83908
Concept ID:
C0353453
Pharmacologic Substance

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