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Results: 16

1.

Squamous cell carcinoma

The presence of squamous cell carcinoma of the skin. [from HPO]

MedGen UID:
505376
Concept ID:
CN002585
Finding
2.

Serpin

Irreversible serine proteinase inhibitors that exert their action on peptidases. Serpins can be localized inside, or outside of the cell, and are found in all groups of organisms with the exception of fungi. In human plasma, serpins represent approximately 2% of the total protein present. [from NCI]

MedGen UID:
48634
Concept ID:
C0036764
Pharmacologic Substance
3.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
4.

Squamous Cell Carcinoma

a cancer arises from a cell called squamous epithelium. this is the most common type of skin cancer [from CHV]

MedGen UID:
2874
Concept ID:
C0007137
Neoplastic Process
5.

Cystatin C

An extracellular cystatin subtype that is abundantly expressed in bodily fluids. It may play a role in the inhibition of interstitial CYSTEINE PROTEASES. [from MeSH]

MedGen UID:
74783
Concept ID:
C0071744
Pharmacologic Substance
6.

Sodium lauryl sulfate

An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry. [from MeSH]

MedGen UID:
52400
Concept ID:
C0037506
Pharmacologic Substance
7.

Serine Proteinase Inhibitors

Compounds that inhibit serine endopeptidases. Serine proteinase inhibitors can be either exogenous or endogenous. Endogenous moieties occur naturally; however, exogenous inhibitors can be introduced to provide therapeutic benefit, such as antiretroviral or antiviral pharmaceuticals. [from NCI]

MedGen UID:
20708
Concept ID:
C0036733
Pharmacologic Substance
8.

dodecyl sulfate

MedGen UID:
16070
Concept ID:
C0058632
Pharmacologic Substance
9.

Serine

A non-essential amino acid in humans (synthesized by the body), Serine is present and functionally important in many proteins. With an alcohol group, serine is needed for the metabolism of fats, fatty acids, and cell membranes; muscle growth; and a healthy immune system. It also plays a major role in pyrimidine, purine, creatine, and porphyrin biosynthetic pathways. Serine is also found at the active site of the serine protease enzyme class that includes trypsin and chymotrypsin. (NCI04) [from NCI]

MedGen UID:
11382
Concept ID:
C0036720
Pharmacologic Substance
10.

Carcinoma

type of cancer [from CHV]

MedGen UID:
2867
Concept ID:
C0007097
Neoplastic Process
11.

CHYMOTRYPSIN

A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side. [from MeSH]

MedGen UID:
971
Concept ID:
C0008742
Pharmacologic Substance
12.

Proteinase inhibitor (substance)

MedGen UID:
743840
Concept ID:
C1961133
Pharmacologic Substance
13.

S-1 Antimetabolite agent

a kind of cancer treatment drug [from CHV]

MedGen UID:
163909
Concept ID:
C0879262
Pharmacologic Substance
14.

polyacrylamide gels

An electrophoresis gel composed of polyacrylamide in an aqueous buffer. [from NCI]

MedGen UID:
74728
Concept ID:
C0071500
Pharmacologic Substance
15.

Endopeptidases

nonEC category which corresponds to EC 3.4.21, EC 3.4.22, EC 3.4.23, EC 3.4.24, and EC 3.4.99. [from CRISP]

MedGen UID:
45389
Concept ID:
C0030946
Pharmacologic Substance
16.

Protein binding

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments. [from MeSH]

MedGen UID:
18704
Concept ID:
C0033618
Molecular Function

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