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Results: 1 to 20 of 27

1.

Estrogens

A class of natural or synthetic hormones that binds to a cytoplasmic receptor and initiates translocation of the hormone-receptor complex to the nucleus of target cells of tissues rich in estrogen receptors, including the endometrium, myometrium, oviduct, vagina, fallopian tube, cervix, brain, liver, placenta, ovarian cells, Leydigs cells, kidney, prostate, pancreas, heart, and skin. (NCI) [from NCI]

MedGen UID:
8701
Concept ID:
C0014939
Pharmacologic Substance
2.

hydroxytamoxifen

MedGen UID:
220263
Concept ID:
C1259921
Pharmacologic Substance
3.

agonists

Used with chemicals, drugs, and endogenous substances to indicate substances or agents that have affinity for a receptor and intrinsic activity at that receptor. (From Textbook of Pharmacology, 1991, p.16) [from MeSH]

MedGen UID:
116746
Concept ID:
C0243192
Pharmacologic Substance
4.

Tamoxifen

syntactic hormone used in breast cancer treatment [from CHV]

MedGen UID:
52642
Concept ID:
C0039286
Pharmacologic Substance
5.

Genistein

An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE. [from MeSH]

MedGen UID:
29583
Concept ID:
C0061202
Pharmacologic Substance
6.

4-hydroxytamoxifen

A tamoxifen metabolite with both estrogenic and anti-estrogenic effects. 4-hydroxytamoxifen has a higher affinity for the estrogen receptor than tamoxifen, and functions as an antagonist in breast cancer cells. (NCI04) [from NCI]

MedGen UID:
24951
Concept ID:
C0048403
Pharmacologic Substance
7.

Zinc

An element with atomic symbol Zn, atomic number 30, and atomic weight 65.39. [from NCI]

MedGen UID:
22752
Concept ID:
C0043481
Pharmacologic Substance
8.

Testosterone

A synthetic form of the endogenous androgenic steroid testosterone. Due to rapid metabolism by the liver, therapeutic testosterone is generally administered as an ester derivative. This agent and its derivatives promote the maintenance of male sex characteristics. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42926&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42926&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C862" NCI Thesaurus) [from PDQ]

MedGen UID:
21105
Concept ID:
C0039601
Pharmacologic Substance
9.

Progesterone

a type of female sex hormone [from CHV]

MedGen UID:
18661
Concept ID:
C0033308
Pharmacologic Substance
10.

Estrone

The synthetic form of a naturally occurring estrogen estrone. Estrone diffuses through the cell membrane and binds to and subsequently activates the nuclear estrogen receptor found in the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. The activated hormone-receptor complex gets translocated to the nucleus where it binds to the estrogen response element on the DNA and promotes the transcription of target genes involved in the functioning of the female reproductive system and secondary sex characteristics. Estrone increases the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins, as well as suppresses the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. [from NCI]

MedGen UID:
8702
Concept ID:
C0014942
Pharmacologic Substance
11.

Estriol

A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol. [from MeSH]

MedGen UID:
4555
Concept ID:
C0014927
Pharmacologic Substance
12.

Estradiol

a steroid sex hormone [from CHV]

MedGen UID:
4551
Concept ID:
C0014912
Pharmacologic Substance
13.

Coumestrol

A daidzein derivative occurring naturally in forage crops which has some estrogenic activity. [from MeSH]

MedGen UID:
3258
Concept ID:
C0010209
Pharmacologic Substance
14.

Aldosterone

A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. [from MeSH]

MedGen UID:
1404
Concept ID:
C0002006
Pharmacologic Substance
15.

Amino acid

One of several molecules that join together to form proteins. There are 20 common amino acids found in proteins. [from NCI]

MedGen UID:
250
Concept ID:
C0002520
Pharmacologic Substance
16.

Tamoxifen

MedGen UID:
450034
Concept ID:
CN077559
Pharmacologic Substance
17.

Ligand Binding

Ligand Binding is the tight and specific (high affinity) interaction between a small molecule (typically) and a macromolecule (usually protein) that ordinarily results in modification of its function, e.g., antigen-antibody binding, hormone- or neurotransmitter-receptor binding. [from NCI]

MedGen UID:
309303
Concept ID:
C1517880
Molecular Function
18.

Hydrocortisone

The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. [from MeSH]

MedGen UID:
9337
Concept ID:
C0020268
Pharmacologic Substance
19.

Aerodiol

MedGen UID:
365356
Concept ID:
C1951509
Pharmacologic Substance
20.

Vivelle

MedGen UID:
196344
Concept ID:
C0724374
Pharmacologic Substance

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