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Nissl degeneration

MedGen UID:
11217
Concept ID:
C0035354
Cell or Molecular Dysfunction
Synonyms: Axon Reaction; Axon Reactions; Axonal Reaction; Axonal Reactions; Degeneration, Nissl; Degeneration, Retrograde; Degenerations, Retrograde; Nissl Degeneration; Reaction, Axon; Reaction, Axonal; Reactions, Axon; Reactions, Axonal; Retrograde Degeneration; Retrograde Degenerations
SNOMED CT: Nissl degeneration (46551009)
 

Definition

Pathologic changes that occur in the axon and cell body of a neuron proximal to an axonal lesion. The process is characterized by central chromatolysis which features flattening and displacement of the nucleus, loss of Nissl bodies, and cellular edema. Central chromatolysis primarily occurs in lower motor neurons. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGNissl degeneration

Recent clinical studies

Etiology

Abegg M, Dysli M, Wolf S, Kowal J, Dufour P, Zinkernagel M
Ophthalmology 2014 Jan;121(1):142-9. Epub 2013 Oct 15 doi: 10.1016/j.ophtha.2013.08.045. [Epub ahead of print] PMID: 24139122
Rocca MA, Mesaros S, Preziosa P, Pagani E, Stosic-Opincal T, Dujmovic-Basuroski I, Drulovic J, Filippi M
Mult Scler 2013 Oct;19(12):1610-7. Epub 2013 Apr 9 doi: 10.1177/1352458513485146. [Epub ahead of print] PMID: 23572238
Sriram P, Graham SL, Wang C, Yiannikas C, Garrick R, Klistorner A
Invest Ophthalmol Vis Sci 2012 Mar 9;53(3):1271-5. doi: 10.1167/iovs.11-8732. PMID: 22222509
Marcuzzo S, Zucca I, Mastropietro A, de Rosbo NK, Cavalcante P, Tartari S, Bonanno S, Preite L, Mantegazza R, Bernasconi P
Exp Neurol 2011 Sep;231(1):30-7. Epub 2011 May 14 doi: 10.1016/j.expneurol.2011.05.007. [Epub ahead of print] PMID: 21620832
Liang Z, Zeng J, Zhang C, Liu S, Ling X, Xu A, Ling L, Wang F, Pei Z
Cerebrovasc Dis 2008;25(3):209-16. Epub 2008 Jan 24 doi: 10.1159/000113858. [Epub ahead of print] PMID: 18216462

Diagnosis

Abegg M, Dysli M, Wolf S, Kowal J, Dufour P, Zinkernagel M
Ophthalmology 2014 Jan;121(1):142-9. Epub 2013 Oct 15 doi: 10.1016/j.ophtha.2013.08.045. [Epub ahead of print] PMID: 24139122
Park HY, Park YG, Cho AH, Park CK
Ophthalmology 2013 Jun;120(6):1292-9. Epub 2013 Feb 8 doi: 10.1016/j.ophtha.2012.11.021. [Epub ahead of print] PMID: 23395544
Sriram P, Graham SL, Wang C, Yiannikas C, Garrick R, Klistorner A
Invest Ophthalmol Vis Sci 2012 Mar 9;53(3):1271-5. doi: 10.1167/iovs.11-8732. PMID: 22222509
Guedes ME, Almeida AC, Patricio MS, Costa JM
BMJ Case Rep 2011 Sep 28;2011 doi: 10.1136/bcr.08.2011.4653. PMID: 22679330Free PMC Article
Jindahra P, Petrie A, Plant GT
Brain 2009 Mar;132(Pt 3):628-34. Epub 2009 Feb 18 doi: 10.1093/brain/awp001. [Epub ahead of print] PMID: 19224900

Therapy

Itoi T, Tsuchiya T, Tanaka R, Ikeuchi N, Sofuni A
Dig Endosc 2013 May;25 Suppl 2:117-21. doi: 10.1111/den.12064. PMID: 23617661
Burkus JK, Dryer RF, Peloza JH
J Neurosurg Spine 2013 Feb;18(2):112-21. Epub 2012 Nov 30 doi: 10.3171/2012.10.SPINE11908. [Epub ahead of print] PMID: 23199378
Nutini DN, Fine JS
PM R 2012 Jan;4(1):81-3. doi: 10.1016/j.pmrj.2011.10.012. PMID: 22269458
Li HG, Yee R, Klein GJ
J Cardiovasc Electrophysiol 1995 Mar;6(3):170-3. PMID: 7620642
Koliatsos VE, Applegate MD, Knüsel B, Junard EO, Burton LE, Mobley WC, Hefti FF, Price DL
Exp Neurol 1991 May;112(2):161-73. PMID: 2037030

Prognosis

Millington RS, Yasuda CL, Jindahra P, Jenkinson M, Barbur JL, Kennard C, Cendes F, Plant GT, Bridge H
J Neurol Neurosurg Psychiatry 2014 Apr;85(4):379-86. Epub 2013 Oct 25 doi: 10.1136/jnnp-2013-306577. [Epub ahead of print] PMID: 24163431
Dziewulska D, Gogol A, Gogol P, Rafalowska J
Clin Neuropathol 2013 Nov-Dec;32(6):480-5. doi: 10.5414/NP300623. PMID: 23743157
Jindahra P, Petrie A, Plant GT
Brain 2012 Feb;135(Pt 2):534-41. Epub 2012 Feb 1 doi: 10.1093/brain/awr324. [Epub ahead of print] PMID: 22300877
Sriram P, Graham SL, Wang C, Yiannikas C, Garrick R, Klistorner A
Invest Ophthalmol Vis Sci 2012 Mar 9;53(3):1271-5. doi: 10.1167/iovs.11-8732. PMID: 22222509
Liang Z, Zeng J, Zhang C, Liu S, Ling X, Xu A, Ling L, Wang F, Pei Z
Cerebrovasc Dis 2008;25(3):209-16. Epub 2008 Jan 24 doi: 10.1159/000113858. [Epub ahead of print] PMID: 18216462

Clinical prediction guides

Ogawa K, Kamei S, Ichihara K, Uehara K, Suzuki Y, Uchihara T, Yoshihashi H, Chong JM
Clin Neuropathol 2014 Jan-Feb;33(1):68-75. doi: 10.5414/NP300594. PMID: 24216149
Millington RS, Yasuda CL, Jindahra P, Jenkinson M, Barbur JL, Kennard C, Cendes F, Plant GT, Bridge H
J Neurol Neurosurg Psychiatry 2014 Apr;85(4):379-86. Epub 2013 Oct 25 doi: 10.1136/jnnp-2013-306577. [Epub ahead of print] PMID: 24163431
Jindahra P, Petrie A, Plant GT
Brain 2012 Feb;135(Pt 2):534-41. Epub 2012 Feb 1 doi: 10.1093/brain/awr324. [Epub ahead of print] PMID: 22300877
Marcuzzo S, Zucca I, Mastropietro A, de Rosbo NK, Cavalcante P, Tartari S, Bonanno S, Preite L, Mantegazza R, Bernasconi P
Exp Neurol 2011 Sep;231(1):30-7. Epub 2011 May 14 doi: 10.1016/j.expneurol.2011.05.007. [Epub ahead of print] PMID: 21620832
Liang Z, Zeng J, Zhang C, Liu S, Ling X, Xu A, Ling L, Wang F, Pei Z
Cerebrovasc Dis 2008;25(3):209-16. Epub 2008 Jan 24 doi: 10.1159/000113858. [Epub ahead of print] PMID: 18216462

Recent systematic reviews

Fu R, Selph S, McDonagh M, Peterson K, Tiwari A, Chou R, Helfand M
Ann Intern Med 2013 Jun 18;158(12):890-902. doi: 10.7326/0003-4819-158-12-201306180-00006. PMID: 23778906
Petzold A, de Boer JF, Schippling S, Vermersch P, Kardon R, Green A, Calabresi PA, Polman C
Lancet Neurol 2010 Sep;9(9):921-32. doi: 10.1016/S1474-4422(10)70168-X. PMID: 20723847
Knox DL, Eagle RC Jr, Green WR
Arch Ophthalmol 2007 Mar;125(3):347-53. doi: 10.1001/archopht.125.3.347. PMID: 17353405
Chang CY, Cass SP
Am J Otol 1999 Jan;20(1):96-114. PMID: 9918183

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