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Zidovudine

MedGen UID:
21959
Concept ID:
C0043474
Pharmacologic Substance
Synonyms: 3' Azido 2',3' Dideoxythymidine; 3' Azido 3' deoxythymidine; 3'-Azido-2',3'-Dideoxythymidine; 3'-Azido-3'-deoxythymidine; Antiviral AZT; Azidothymidine; AZT (Antiviral); AZT Antiviral; AZT, Antiviral; Thymidine, 3'-azido-3'-deoxy-
SNOMED CT: Zidovudine product (27479000); AZT - Azidothymidine (27479000); Zidovudine (387151007); AZT (387151007); Azidothymidine (387151007); Zidovudine (27479000); Azidothymidine (27479000); AZT (27479000)
 

Definition

an antiviral drug used in the treatment of AIDS [from CHV]

Recent clinical studies

Etiology

Li T, Guo F, Li Y, Zhang C, Han Y, Lye W, He Y, Lu H, Xie J, Huang A, Li Y, Tang X, Wang H, Zhang T, Gao G, Lei J, Zhang X, Wu X, Sun Y, Bai J, Luo L, Wang H
Chin Med J (Engl) 2014;127(1):59-65. PMID: 24384425
Parrish DD, Blevins M, Megazzini KM, Shepherd BE, Mohammed MY, Wester CW, Vermund SH, Aliyu MH
Int J STD AIDS 2014 Apr;25(5):355-9. Epub 2013 Oct 8 doi: 10.1177/0956462413506887. [Epub ahead of print] PMID: 24104694
Kchour G, Rezaee R, Farid R, Ghantous A, Rafatpanah H, Tarhini M, Kooshyar MM, El Hajj H, Berry F, Mortada M, Nasser R, Shirdel A, Dassouki Z, Ezzedine M, Rahimi H, Ghavamzadeh A, de Thé H, Hermine O, Mahmoudi M, Bazarbachi A
Retrovirology 2013 Aug 20;10:91. doi: 10.1186/1742-4690-10-91. [Epub ahead of print] PMID: 23962110Free PMC Article
André-Schmutz I, Dal-Cortivo L, Six E, Kaltenbach S, Cocchiarella F, Le Chenadec J, Cagnard N, Cordier AG, Benachi A, Mandelbrot L, Azria E, Bouallag N, Luce S, Ternaux B, Reimann C, Revy P, Radford-Weiss I, Leschi C, Recchia A, Mavilio F, Cavazzana M, Blanche S
J Infect Dis 2013 Jul 15;208(2):235-43. Epub 2013 Apr 4 doi: 10.1093/infdis/jit149. [Epub ahead of print] PMID: 23559464
Shey MS, Kongnyuy EJ, Alobwede SM, Wiysonge CS
Cochrane Database Syst Rev 2013 Mar 28;3:CD005481. doi: 10.1002/14651858.CD005481.pub3. PMID: 23543540

Diagnosis

Kim AH, Jang W, Kim Y, Park YJ, Han K, Oh EJ
J Clin Lab Anal 2013 Sep;27(5):373-8. doi: 10.1002/jcla.21613. PMID: 24038222
Jin Y, Yang F, Du L
Colloids Surf B Biointerfaces 2013 Dec 1;112:421-8. Epub 2013 Aug 28 doi: 10.1016/j.colsurfb.2013.08.021. [Epub ahead of print] PMID: 24036626
Kchour G, Rezaee R, Farid R, Ghantous A, Rafatpanah H, Tarhini M, Kooshyar MM, El Hajj H, Berry F, Mortada M, Nasser R, Shirdel A, Dassouki Z, Ezzedine M, Rahimi H, Ghavamzadeh A, de Thé H, Hermine O, Mahmoudi M, Bazarbachi A
Retrovirology 2013 Aug 20;10:91. doi: 10.1186/1742-4690-10-91. [Epub ahead of print] PMID: 23962110Free PMC Article
Neubert J, Pfeffer M, Borkhardt A, Niehues T, Adams O, Bolten M, Reuter S, Stannigel H, Laws HJ
BMC Pregnancy Childbirth 2013 Jan 24;13:22. doi: 10.1186/1471-2393-13-22. [Epub ahead of print] PMID: 23347580Free PMC Article
Notari S, Sergi M, Montesano C, Ivanovic J, Narciso P, Pucillo LP, Ascenzi P
IUBMB Life 2012 May;64(5):443-9. Epub 2012 Apr 4 doi: 10.1002/iub.1025. [Epub ahead of print] PMID: 22473795

Therapy

Parrish DD, Blevins M, Megazzini KM, Shepherd BE, Mohammed MY, Wester CW, Vermund SH, Aliyu MH
Int J STD AIDS 2014 Apr;25(5):355-9. Epub 2013 Oct 8 doi: 10.1177/0956462413506887. [Epub ahead of print] PMID: 24104694
Jin Y, Yang F, Du L
Colloids Surf B Biointerfaces 2013 Dec 1;112:421-8. Epub 2013 Aug 28 doi: 10.1016/j.colsurfb.2013.08.021. [Epub ahead of print] PMID: 24036626
Kchour G, Rezaee R, Farid R, Ghantous A, Rafatpanah H, Tarhini M, Kooshyar MM, El Hajj H, Berry F, Mortada M, Nasser R, Shirdel A, Dassouki Z, Ezzedine M, Rahimi H, Ghavamzadeh A, de Thé H, Hermine O, Mahmoudi M, Bazarbachi A
Retrovirology 2013 Aug 20;10:91. doi: 10.1186/1742-4690-10-91. [Epub ahead of print] PMID: 23962110Free PMC Article
Soares KC, Rediguieri CF, Souza J, Serra CH, Abrahamsson B, Groot DW, Kopp S, Langguth P, Polli JE, Shah VP, Dressman J
J Pharm Sci 2013 Aug;102(8):2409-23. Epub 2013 Jun 10 doi: 10.1002/jps.23624. [Epub ahead of print] PMID: 23754446
André-Schmutz I, Dal-Cortivo L, Six E, Kaltenbach S, Cocchiarella F, Le Chenadec J, Cagnard N, Cordier AG, Benachi A, Mandelbrot L, Azria E, Bouallag N, Luce S, Ternaux B, Reimann C, Revy P, Radford-Weiss I, Leschi C, Recchia A, Mavilio F, Cavazzana M, Blanche S
J Infect Dis 2013 Jul 15;208(2):235-43. Epub 2013 Apr 4 doi: 10.1093/infdis/jit149. [Epub ahead of print] PMID: 23559464

Prognosis

Renner LA, Dicko F, Kouéta F, Malateste K, Gueye RD, Aka E, Eboua TK, Azondékon A, Okomo U, Touré P, Ekouévi D, Leroy V; IeDEA West Africa Paediatric Collaboration
J Int AIDS Soc 2013 Sep 17;16(1):18024. PMID: 24047928Free PMC Article
Kchour G, Rezaee R, Farid R, Ghantous A, Rafatpanah H, Tarhini M, Kooshyar MM, El Hajj H, Berry F, Mortada M, Nasser R, Shirdel A, Dassouki Z, Ezzedine M, Rahimi H, Ghavamzadeh A, de Thé H, Hermine O, Mahmoudi M, Bazarbachi A
Retrovirology 2013 Aug 20;10:91. doi: 10.1186/1742-4690-10-91. [Epub ahead of print] PMID: 23962110Free PMC Article
Soares KC, Rediguieri CF, Souza J, Serra CH, Abrahamsson B, Groot DW, Kopp S, Langguth P, Polli JE, Shah VP, Dressman J
J Pharm Sci 2013 Aug;102(8):2409-23. Epub 2013 Jun 10 doi: 10.1002/jps.23624. [Epub ahead of print] PMID: 23754446
Wang R, Weng J, Moyo S, Pain D, Barr CD, Maruapula D, Mongwato D, Makhema J, Novitsky V, Essex M
AIDS Res Hum Retroviruses 2013 Jun;29(6):901-6. Epub 2013 Apr 19 doi: 10.1089/AID.2012.0294. [Epub ahead of print] PMID: 23521375Free PMC Article
Chen J, Flexner C, Liberman RG, Skipper PL, Louissaint NA, Tannenbaum SR, Hendrix CW, Fuchs EJ
J Acquir Immune Defic Syndr 2012 Dec 15;61(5):593-9. doi: 10.1097/QAI.0b013e3182717c98. PMID: 23187888Free PMC Article

Clinical prediction guides

Renner LA, Dicko F, Kouéta F, Malateste K, Gueye RD, Aka E, Eboua TK, Azondékon A, Okomo U, Touré P, Ekouévi D, Leroy V; IeDEA West Africa Paediatric Collaboration
J Int AIDS Soc 2013 Sep 17;16(1):18024. PMID: 24047928Free PMC Article
Kchour G, Rezaee R, Farid R, Ghantous A, Rafatpanah H, Tarhini M, Kooshyar MM, El Hajj H, Berry F, Mortada M, Nasser R, Shirdel A, Dassouki Z, Ezzedine M, Rahimi H, Ghavamzadeh A, de Thé H, Hermine O, Mahmoudi M, Bazarbachi A
Retrovirology 2013 Aug 20;10:91. doi: 10.1186/1742-4690-10-91. [Epub ahead of print] PMID: 23962110Free PMC Article
Fauchet F, Treluyer JM, Frange P, Urien S, Foissac F, Bouazza N, Benaboud S, Blanche S, Hirt D
Antimicrob Agents Chemother 2013 Oct;57(10):4801-8. Epub 2013 Jul 22 doi: 10.1128/AAC.00911-13. [Epub ahead of print] PMID: 23877688Free PMC Article
Soares KC, Rediguieri CF, Souza J, Serra CH, Abrahamsson B, Groot DW, Kopp S, Langguth P, Polli JE, Shah VP, Dressman J
J Pharm Sci 2013 Aug;102(8):2409-23. Epub 2013 Jun 10 doi: 10.1002/jps.23624. [Epub ahead of print] PMID: 23754446
Santos JV, Pina ME, Marques MP, de Carvalho LA
Drug Dev Ind Pharm 2013 Aug;39(8):1154-66. Epub 2012 Mar 23 doi: 10.3109/03639045.2012.669129. [Epub ahead of print] PMID: 22439754

Recent systematic reviews

Shey MS, Kongnyuy EJ, Alobwede SM, Wiysonge CS
Cochrane Database Syst Rev 2013 Mar 28;3:CD005481. doi: 10.1002/14651858.CD005481.pub3. PMID: 23543540
Spaulding A, Rutherford GW, Siegfried N
Cochrane Database Syst Rev 2010 Oct 6;(10):CD008740. doi: 10.1002/14651858.CD008740. PMID: 20927777
Spaulding A, Rutherford GW, Siegfried N
Cochrane Database Syst Rev 2010 Aug 4;(8):CD008651. doi: 10.1002/14651858.CD008651. PMID: 20687097
Bazarbachi A, Plumelle Y, Carlos Ramos J, Tortevoye P, Otrock Z, Taylor G, Gessain A, Harrington W, Panelatti G, Hermine O
J Clin Oncol 2010 Sep 20;28(27):4177-83. Epub 2010 Jun 28 doi: 10.1200/JCO.2010.28.0669. [Epub ahead of print] PMID: 20585095
Shey M, Kongnyuy EJ, Shang J, Wiysonge CS
Cochrane Database Syst Rev 2009 Jul 8;(3):CD005481. doi: 10.1002/14651858.CD005481.pub2. PMID: 19588374

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