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Autoimmune disease

MedGen UID:
2135
Concept ID:
C0004364
Disease or Syndrome
Synonyms: Autoimmune Diseases
SNOMED CT: Autoimmune disease (85828009); Autoimmune disorder (85828009)
 
OMIM®: 109100

Definition

Your body's immune system protects you from disease and infection. But if you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake. Autoimmune diseases can affect many parts of the body. No one is sure what causes autoimmune diseases. They do tend to run in families. Women - particularly African-American, Hispanic-American, and Native-American women - have a higher risk for some autoimmune diseases. There are more than 80 types of autoimmune diseases, and some have similar symptoms. This makes it hard for your health care provider to know if you really have one of these diseases, and if so, which one. Getting a diagnosis can be frustrating and stressful. Often, the first symptoms are fatigue, muscle aches and a low fever. The classic sign of an autoimmune disease is inflammation, which can cause redness, heat, pain and swelling. The diseases may also have flare-ups, when they get worse, and remissions, when symptoms get better or disappear. Treatment depends on the disease, but in most cases one important goal is to reduce inflammation. Sometimes doctors prescribe corticosteroids or other drugs that reduce your immune response.  [from MedlinePlus]

Clinical features

Autoimmune antibody positivity
MedGen UID:
807392
Concept ID:
CN218493
Finding
The presence of an antibody directed against the organism's own cells or tissues.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGAutoimmune disease

Recent clinical studies

Etiology

McAdoo SP, Tanna A, Randone O, Tam FW, Tarzi RM, Levy JB, Griffith M, Lightstone L, Cook HT, Cairns T, Pusey CD
Rheumatology (Oxford) 2015 Jun;54(6):1025-32. Epub 2014 Nov 26 doi: 10.1093/rheumatology/keu445. [Epub ahead of print] PMID: 25431483Free PMC Article
Wu LC, Hwang CY, Chung PI, Hua TC, Chen YD, Chu SY, Lee DD, Chang YT, Wang WJ, Liu HN, Chen CC
Pediatr Allergy Immunol 2014 Oct;25(6):586-92. doi: 10.1111/pai.12274. PMID: 25223227
Ellis JA, Kemp AS, Ponsonby AL
Expert Rev Mol Med 2014 Mar 7;16:e4. doi: 10.1017/erm.2014.5. PMID: 24602341
Liu ZW, Masterson LM, Srouji IA, Musonda P, Scott DG
Otolaryngol Head Neck Surg 2012 Dec;147(6):1108-13. Epub 2012 Aug 29 doi: 10.1177/0194599812459024. [Epub ahead of print] PMID: 22931896
Linneberg A, Madsen F, Skaaby T
Curr Opin Allergy Clin Immunol 2012 Dec;12(6):635-9. doi: 10.1097/ACI.0b013e3283588c8d. PMID: 22914311

Diagnosis

del Rosario RC, Poschmann J, Rouam SL, Png E, Khor CC, Hibberd ML, Prabhakar S
Nat Methods 2015 May;12(5):458-64. Epub 2015 Mar 23 doi: 10.1038/nmeth.3326. [Epub ahead of print] PMID: 25799442
McAdoo SP, Tanna A, Randone O, Tam FW, Tarzi RM, Levy JB, Griffith M, Lightstone L, Cook HT, Cairns T, Pusey CD
Rheumatology (Oxford) 2015 Jun;54(6):1025-32. Epub 2014 Nov 26 doi: 10.1093/rheumatology/keu445. [Epub ahead of print] PMID: 25431483Free PMC Article
Fabris M, Zago S, Tosolini R, Melli P, Bizzaro N, Tonutti E
Pediatrics 2014 Dec;134(6):e1706-8. Epub 2014 Nov 10 doi: 10.1542/peds.2013-3914. [Epub ahead of print] PMID: 25384487
Hu ZD, Deng AM
Clin Chim Acta 2014 Nov 1;437:14-8. Epub 2014 Jun 24 doi: 10.1016/j.cca.2014.06.015. [Epub ahead of print] PMID: 24972003
Liu ZW, Masterson LM, Srouji IA, Musonda P, Scott DG
Otolaryngol Head Neck Surg 2012 Dec;147(6):1108-13. Epub 2012 Aug 29 doi: 10.1177/0194599812459024. [Epub ahead of print] PMID: 22931896

Therapy

Sato R, Ikuma M, Takagi K, Yamagishi Y, Asano J, Matsunaga Y, Watanabe H
Medicine (Baltimore) 2015 Jan;94(1):e386. doi: 10.1097/MD.0000000000000386. PMID: 25569668
McAdoo SP, Tanna A, Randone O, Tam FW, Tarzi RM, Levy JB, Griffith M, Lightstone L, Cook HT, Cairns T, Pusey CD
Rheumatology (Oxford) 2015 Jun;54(6):1025-32. Epub 2014 Nov 26 doi: 10.1093/rheumatology/keu445. [Epub ahead of print] PMID: 25431483Free PMC Article
Pedersen M, Andersen R, Nørgaard P, Jacobsen S, Thielsen P, Thor Straten P, Svane IM
Cancer Immunol Immunother 2014 Dec;63(12):1341-6. Epub 2014 Sep 17 doi: 10.1007/s00262-014-1607-y. [Epub ahead of print] PMID: 25227926
Liu ZW, Masterson LM, Srouji IA, Musonda P, Scott DG
Otolaryngol Head Neck Surg 2012 Dec;147(6):1108-13. Epub 2012 Aug 29 doi: 10.1177/0194599812459024. [Epub ahead of print] PMID: 22931896
Linneberg A, Madsen F, Skaaby T
Curr Opin Allergy Clin Immunol 2012 Dec;12(6):635-9. doi: 10.1097/ACI.0b013e3283588c8d. PMID: 22914311

Prognosis

del Rosario RC, Poschmann J, Rouam SL, Png E, Khor CC, Hibberd ML, Prabhakar S
Nat Methods 2015 May;12(5):458-64. Epub 2015 Mar 23 doi: 10.1038/nmeth.3326. [Epub ahead of print] PMID: 25799442
McAdoo SP, Tanna A, Randone O, Tam FW, Tarzi RM, Levy JB, Griffith M, Lightstone L, Cook HT, Cairns T, Pusey CD
Rheumatology (Oxford) 2015 Jun;54(6):1025-32. Epub 2014 Nov 26 doi: 10.1093/rheumatology/keu445. [Epub ahead of print] PMID: 25431483Free PMC Article
Pedersen M, Andersen R, Nørgaard P, Jacobsen S, Thielsen P, Thor Straten P, Svane IM
Cancer Immunol Immunother 2014 Dec;63(12):1341-6. Epub 2014 Sep 17 doi: 10.1007/s00262-014-1607-y. [Epub ahead of print] PMID: 25227926
Abd Rahman AN, Tett SE, Staatz CE
Clin Pharmacokinet 2014 Mar;53(3):227-45. doi: 10.1007/s40262-013-0124-z. PMID: 24327238
Rogers MA, Levine DA, Blumberg N, Fisher GG, Kabeto M, Langa KM
J Autoimmun 2012 May;38(2-3):J97-J102. Epub 2011 Aug 30 doi: 10.1016/j.jaut.2011.08.001. [Epub ahead of print] PMID: 21880464Free PMC Article

Clinical prediction guides

Sato R, Ikuma M, Takagi K, Yamagishi Y, Asano J, Matsunaga Y, Watanabe H
Medicine (Baltimore) 2015 Jan;94(1):e386. doi: 10.1097/MD.0000000000000386. PMID: 25569668
Warren BD, Kinsey WK, McGinnis LK, Christenson LK, Jasti S, Stevens AM, Petroff BK, Petroff MG
Cell Mol Immunol 2014 Nov;11(6):510-21. Epub 2014 Oct 20 doi: 10.1038/cmi.2014.97. [Epub ahead of print] PMID: 25327908Free PMC Article
Pedersen M, Andersen R, Nørgaard P, Jacobsen S, Thielsen P, Thor Straten P, Svane IM
Cancer Immunol Immunother 2014 Dec;63(12):1341-6. Epub 2014 Sep 17 doi: 10.1007/s00262-014-1607-y. [Epub ahead of print] PMID: 25227926
Parks CG, Miller FW, Pollard KM, Selmi C, Germolec D, Joyce K, Rose NR, Humble MC
Int J Mol Sci 2014 Aug 15;15(8):14269-97. doi: 10.3390/ijms150814269. PMID: 25196523Free PMC Article
Liu ZW, Masterson LM, Srouji IA, Musonda P, Scott DG
Otolaryngol Head Neck Surg 2012 Dec;147(6):1108-13. Epub 2012 Aug 29 doi: 10.1177/0194599812459024. [Epub ahead of print] PMID: 22931896

Recent systematic reviews

Parks CG, Miller FW, Pollard KM, Selmi C, Germolec D, Joyce K, Rose NR, Humble MC
Int J Mol Sci 2014 Aug 15;15(8):14269-97. doi: 10.3390/ijms150814269. PMID: 25196523Free PMC Article
McShane CM, Murray LJ, Landgren O, O'Rorke MA, Korde N, Kunzmann AT, Ismail MR, Anderson LA
Cancer Epidemiol Biomarkers Prev 2014 Feb;23(2):332-42. Epub 2014 Jan 22 doi: 10.1158/1055-9965.EPI-13-0695. [Epub ahead of print] PMID: 24451437
Thomas R
Curr Opin Rheumatol 2014 Mar;26(2):211-8. doi: 10.1097/BOR.0000000000000032. PMID: 24389864
de la Hera B, Varadé J, García-Montojo M, Lamas JR, de la Encarnación A, Arroyo R, Fernández-Gutiérrez B, Alvarez-Lafuente R, Urcelay E
PLoS One 2013;8(4):e62090. Epub 2013 Apr 25 doi: 10.1371/journal.pone.0062090. PMID: 23634223Free PMC Article
Kriegel MA, Manson JE, Costenbader KH
Semin Arthritis Rheum 2011 Jun;40(6):512-531.e8. Epub 2010 Nov 2 doi: 10.1016/j.semarthrit.2010.07.009. [Epub ahead of print] PMID: 21047669Free PMC Article

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