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Clonidine

MedGen UID:
3117
Concept ID:
C0009014
Pharmacologic Substance
Synonyms: 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-; Clofenil; Klofenil
SNOMED CT: Clonidine (62782004); Clonidine (372805007)
 

Definition

An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION. [from MeSH]

Term Hierarchy

Recent clinical studies

Etiology

Garg AX, Kurz A, Sessler DI, Cuerden M, Robinson A, Mrkobrada M, Parikh CR, Mizera R, Jones PM, Tiboni M, Font A, Cegarra V, Gomez MF, Meyhoff CS, VanHelder T, Chan MT, Torres D, Parlow J, Clanchet Mde N, Amir M, Bidgoli SJ, Pasin L, Martinsen K, Malaga G, Myles P, Acedillo R, Roshanov PS, Walsh M, Dresser G, Kumar P, Fleischmann E, Villar JC, Painter T, Biccard B, Bergese S, Srinathan S, Cata JP, Chan V, Mehra B, Wijeysundera DN, Leslie K, Forget P, Whitlock R, Yusuf S, Devereaux PJ; POISE-2 Investigators
JAMA 2014 Dec 3;312(21):2254-64. doi: 10.1001/jama.2014.15284. PMID: 25399007
Devereaux PJ, Sessler DI, Leslie K, Kurz A, Mrkobrada M, Alonso-Coello P, Villar JC, Sigamani A, Biccard BM, Meyhoff CS, Parlow JL, Guyatt G, Robinson A, Garg AX, Rodseth RN, Botto F, Lurati Buse G, Xavier D, Chan MT, Tiboni M, Cook D, Kumar PA, Forget P, Malaga G, Fleischmann E, Amir M, Eikelboom J, Mizera R, Torres D, Wang CY, Vanhelder T, Paniagua P, Berwanger O, Srinathan S, Graham M, Pasin L, Le Manach Y, Gao P, Pogue J, Whitlock R, Lamy A, Kearon C, Chow C, Pettit S, Chrolavicius S, Yusuf S; POISE-2 Investigators
N Engl J Med 2014 Apr 17;370(16):1504-13. Epub 2014 Mar 31 doi: 10.1056/NEJMoa1401106. [Epub ahead of print] PMID: 24679061
Bortone L, Bertolizio G, Engelhardt T, Frawley G, Somaini M, Ingelmo PM
Paediatr Anaesth 2014 Jun;24(6):614-9. Epub 2014 Mar 26 doi: 10.1111/pan.12388. [Epub ahead of print] PMID: 24666767
Sulheim D, Fagermoen E, Winger A, Andersen AM, Godang K, Müller F, Rowe PC, Saul JP, Skovlund E, Øie MG, Wyller VB
JAMA Pediatr 2014 Apr;168(4):351-60. doi: 10.1001/jamapediatrics.2013.4647. PMID: 24493300
Mariappan R, Ashokkumar H, Kuppuswamy B
J Neurosurg Anesthesiol 2014 Jul;26(3):192-7. doi: 10.1097/ANA.0b013e3182a2166f. PMID: 23887684

Diagnosis

Lambert P, Cyna AM, Knight N, Middleton P
Cochrane Database Syst Rev 2014 Jan 28;1:CD009633. doi: 10.1002/14651858.CD009633.pub2. PMID: 24470114
Noronha-Neto C, Katz L, Coutinho IC, Maia SB, Souza AS, Amorim MM
Reprod Health 2013 Jul 30;10:37. doi: 10.1186/1742-4755-10-37. [Epub ahead of print] PMID: 23899372Free PMC Article
Christoforidis A, Triantafyllou P, Slavakis A, Katzos G
J Endocrinol Invest 2013 Dec;36(11):1046-50. Epub 2013 Jul 23 doi: 10.3275/9061. [Epub ahead of print] PMID: 23888314
Klein RH, Alvarez-Jimenez R, Sukhai RN, Oostdijk W, Bakker B, Reeser HM, Ballieux BE, Hu P, Klaassen ES, Freijer J, Burggraaf J, Cohen AF, Wit JM
Horm Res Paediatr 2013;79(5):300-9. Epub 2013 Jun 1 doi: 10.1159/000350819. [Epub ahead of print] PMID: 23735833
Naja ZM, Ziade FM, El-Rajab MA, Naccash N, Ayoubi JM
Anesth Analg 2013 Jul;117(1):252-8. Epub 2013 Apr 30 doi: 10.1213/ANE.0b013e31828f28d6. [Epub ahead of print] PMID: 23632052

Therapy

Garg AX, Kurz A, Sessler DI, Cuerden M, Robinson A, Mrkobrada M, Parikh CR, Mizera R, Jones PM, Tiboni M, Font A, Cegarra V, Gomez MF, Meyhoff CS, VanHelder T, Chan MT, Torres D, Parlow J, Clanchet Mde N, Amir M, Bidgoli SJ, Pasin L, Martinsen K, Malaga G, Myles P, Acedillo R, Roshanov PS, Walsh M, Dresser G, Kumar P, Fleischmann E, Villar JC, Painter T, Biccard B, Bergese S, Srinathan S, Cata JP, Chan V, Mehra B, Wijeysundera DN, Leslie K, Forget P, Whitlock R, Yusuf S, Devereaux PJ; POISE-2 Investigators
JAMA 2014 Dec 3;312(21):2254-64. doi: 10.1001/jama.2014.15284. PMID: 25399007
Arenas-Lopez S, Mulla H, Manna S, Durward A, Murdoch IA, Tibby SM
Br J Anaesth 2014 Dec;113(6):964-9. Epub 2014 Jul 30 doi: 10.1093/bja/aeu258. [Epub ahead of print] PMID: 25080430
Strasinger C, Paudel KS, Wu J, Hammell D, Pinninti RR, Hinds BJ, Stinchcomb A
J Pharm Sci 2014 Jun;103(6):1829-38. Epub 2014 May 1 doi: 10.1002/jps.23940. [Epub ahead of print] PMID: 24788096Free PMC Article
Maina A, Arrotta M, Cicogna L, Donvito V, Mischinelli M, Todros T, Rivolo S
BJOG 2014 Nov;121(12):1556-62. Epub 2014 Apr 1 doi: 10.1111/1471-0528.12757. [Epub ahead of print] PMID: 24684734
Mariappan R, Ashokkumar H, Kuppuswamy B
J Neurosurg Anesthesiol 2014 Jul;26(3):192-7. doi: 10.1097/ANA.0b013e3182a2166f. PMID: 23887684

Prognosis

Boogmans T, Vertommen J, Valkenborgh T, Devroe S, Roofthooft E, Van de Velde M
Eur J Anaesthesiol 2014 Apr;31(4):190-6. doi: 10.1097/EJA.0b013e32836249e9. PMID: 23959095
Klein RH, Alvarez-Jimenez R, Sukhai RN, Oostdijk W, Bakker B, Reeser HM, Ballieux BE, Hu P, Klaassen ES, Freijer J, Burggraaf J, Cohen AF, Wit JM
Horm Res Paediatr 2013;79(5):300-9. Epub 2013 Jun 1 doi: 10.1159/000350819. [Epub ahead of print] PMID: 23735833
Heinmiller LJ, Nelson LB, Goldberg MB, Thode AR
J Pediatr Ophthalmol Strabismus 2013 May-Jun;50(3):150-4. Epub 2013 Feb 12 doi: 10.3928/01913913-20130205-02. [Epub ahead of print] PMID: 23394604
Studer FR, Grätz KW, Mutzbauer TS
Oral Maxillofac Surg 2012 Dec;16(4):341-7. Epub 2012 Mar 13 doi: 10.1007/s10006-012-0319-8. [Epub ahead of print] PMID: 22411483
Giacomozzi C, Spadoni GL, Pedicelli S, Scirè G, Cristofori L, Peschiaroli E, Deodati A, Cambiaso P, Cappa M, Cianfarani S
J Endocrinol Invest 2012 Sep;35(8):742-7. Epub 2011 Oct 4 doi: 10.3275/8008. [Epub ahead of print] PMID: 21978975

Clinical prediction guides

Duffett M, Choong K, Foster J, Cheng J, Meade MO, Menon K, Cook DJ
J Crit Care 2014 Oct;29(5):758-63. Epub 2014 Jun 11 doi: 10.1016/j.jcrc.2014.05.029. [Epub ahead of print] PMID: 25015006
Maina A, Arrotta M, Cicogna L, Donvito V, Mischinelli M, Todros T, Rivolo S
BJOG 2014 Nov;121(12):1556-62. Epub 2014 Apr 1 doi: 10.1111/1471-0528.12757. [Epub ahead of print] PMID: 24684734
Bortone L, Bertolizio G, Engelhardt T, Frawley G, Somaini M, Ingelmo PM
Paediatr Anaesth 2014 Jun;24(6):614-9. Epub 2014 Mar 26 doi: 10.1111/pan.12388. [Epub ahead of print] PMID: 24666767
Sulheim D, Fagermoen E, Winger A, Andersen AM, Godang K, Müller F, Rowe PC, Saul JP, Skovlund E, Øie MG, Wyller VB
JAMA Pediatr 2014 Apr;168(4):351-60. doi: 10.1001/jamapediatrics.2013.4647. PMID: 24493300
Boogmans T, Vertommen J, Valkenborgh T, Devroe S, Roofthooft E, Van de Velde M
Eur J Anaesthesiol 2014 Apr;31(4):190-6. doi: 10.1097/EJA.0b013e32836249e9. PMID: 23959095

Recent systematic reviews

Lambert P, Cyna AM, Knight N, Middleton P
Cochrane Database Syst Rev 2014 Jan 28;1:CD009633. doi: 10.1002/14651858.CD009633.pub2. PMID: 24470114
Zhang C, Li J, Zhao D, Wang Y
Clin Ther 2013 Oct;35(10):1622-31. Epub 2013 Sep 25 doi: 10.1016/j.clinthera.2013.08.016. [Epub ahead of print] PMID: 24075150
Noronha-Neto C, Katz L, Coutinho IC, Maia SB, Souza AS, Amorim MM
Reprod Health 2013 Jul 30;10:37. doi: 10.1186/1742-4755-10-37. [Epub ahead of print] PMID: 23899372Free PMC Article
Engelman E, Marsala C
Br J Anaesth 2013 Jan;110(1):21-7. Epub 2012 Sep 21 doi: 10.1093/bja/aes344. [Epub ahead of print] PMID: 23002167
Schnabel A, Poepping DM, Pogatzki-Zahn EM, Zahn PK
Paediatr Anaesth 2011 Dec;21(12):1219-30. doi: 10.1111/j.1460-9592.2011.03715.x. PMID: 22023418

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