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Major affective disorder 2(MAFD2)

MedGen UID:
326975
Concept ID:
C1839839
Mental or Behavioral Dysfunction
Synonyms: BIPOLAR AFFECTIVE DISORDER; MAFD2; MANIC-DEPRESSIVE ILLNESS; MANIC-DEPRESSIVE PSYCHOSIS, X-LINKED
 
Cytogenetic location: Xq28
OMIM®: 309200

Clinical features

Bipolar affective disorder
MedGen UID:
2649
Concept ID:
C0005586
Mental or Behavioral Dysfunction
Bipolar disorder is a serious mental illness. People who have it go through unusual mood changes. They go from very happy, up, and active to very sad and hopeless, down, and inactive, and then back again. They often have normal moods in between. The up feeling is called mania. The down feeling is depression. The causes of bipolar disorder aren't always clear. It runs in families. Abnormal brain structure and function may also play a role. Bipolar disorder often starts in a person's late teen or early adult years. But children and adults can have bipolar disorder too. The illness usually lasts a lifetime. If you think you may have it, tell your health care provider. A medical checkup can rule out other illnesses that might cause your mood changes. If not treated, bipolar disorder can lead to damaged relationships, poor job or school performance, and even suicide. However, there are effective treatments to control symptoms: medicine and talk therapy. A combination usually works best. NIH: National Institute of Mental Health.

Recent clinical studies

Diagnosis

Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. [Epub ahead of print] PMID: 25687279
Xiang YT, Hu C, Wang G, Zheng QW, Fang YR, Ungvari GS, Kilbourne AM, Lai KY, Si TM, Chen DF, Lu Z, Yang HC, Hu J, Chen ZY, Huang Y, Sun J, Wang XP, Li HC, Zhang JB, Chiu HF
Hum Psychopharmacol 2012 Nov;27(6):626-31. Epub 2012 Oct 2 doi: 10.1002/hup.2262. [Epub ahead of print] PMID: 23027671

Therapy

Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. [Epub ahead of print] PMID: 25687279
Xiang YT, Hu C, Wang G, Zheng QW, Fang YR, Ungvari GS, Kilbourne AM, Lai KY, Si TM, Chen DF, Lu Z, Yang HC, Hu J, Chen ZY, Huang Y, Sun J, Wang XP, Li HC, Zhang JB, Chiu HF
Hum Psychopharmacol 2012 Nov;27(6):626-31. Epub 2012 Oct 2 doi: 10.1002/hup.2262. [Epub ahead of print] PMID: 23027671

Clinical prediction guides

Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. [Epub ahead of print] PMID: 25687279

Recent systematic reviews

Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. [Epub ahead of print] PMID: 25687279

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