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Results: 1 to 20 of 29

1.

Heparin

A sulfur-rich glycosaminoglycan with anticoagulant property. Heparin binds to antithrombin III to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors, such as factors IX, X, XI, and XII, thereby preventing the polymerization of fibrinogen to fibrin and the subsequent formation of clots. [from NCI]

MedGen UID:
42413
Concept ID:
C0019134
Pharmacologic Substance
2.

MedGen UID:
109303
Concept ID:
C0596988
3.

Antithrombins

endogenous family of proteins belonging to the serpin superfamily that neutralizes the action of thrombin; includes fibrin and antithrombin III. [from CRISP]

MedGen UID:
354
Concept ID:
C0003440
Pharmacologic Substance
4.

Pulmonary embolism

The closure of the pulmonary artery or one of its branches by an embolus, sometimes associated with infarction of the lung. [from NCI]

MedGen UID:
11027
Concept ID:
C0034065
Disease or Syndrome
5.

Heterogeneous

Made up of elements or ingredients that are not alike. [from NCI]

MedGen UID:
5539
Concept ID:
C0019409
6.

Embolism

The blockage of a blood vessel lumen by air or solid material such as blood clot or other tissues (e.g., adipose tissue, cancer cells) that have migrated from another anatomic site. [from NCI]

MedGen UID:
4916
Concept ID:
C0013922
Pathologic Function
7.

Pulmonary embolism

MedGen UID:
505155
Concept ID:
CN001998
Finding
8.

Abnormality

A condition that differs from the usual physical or mental state. [from NCI]

MedGen UID:
309940
Concept ID:
C1704258
Finding
9.

Heparin Binding

Heparin Binding involves a biophysical interaction between a biological molecule, such as a protein, and heparin, a sulfated glycosaminoglycan of mixed polysaccharide nature, varying in molecular weight, and released by mast cells and basophils in many tissues. Lipotrophic by activation of lipoprotein lipase, anticoagulant heparin also binds to and enhances antithrombin III activity and inhibits several coagulation factors. [from NCI]

MedGen UID:
218856
Concept ID:
C1148608
Molecular Function
10.

MedGen UID:
108287
Concept ID:
C0577559
11.

CHARGE association

CHARGE is a mnemonic for coloboma, heart defects, choanal atresia, retarded growth and development, genital abnormalities, and ear anomalies. CHARGE syndrome is characterized by the following: Unilateral or bilateral coloboma of the iris, retina-choroid, and/or disc with or without microphthalmos (80%-90% of individuals). Unilateral or bilateral choanal atresia or stenosis (50%-60%). Cranial nerve dysfunction resulting in hyposmia or anosmia, unilateral or bilateral facial palsy (40%), impaired hearing, and/or swallowing problems (70%-90%). Abnormal outer ears, ossicular malformations, Mondini defect of the cochlea and absent or hypoplastic semicircular canals (>90%). Cryptorchidism in males and hypogonadotrophic hypogonadism in both males and females. Developmental delay. Cardiovascular malformations (75%-85%). Growth deficiency (70%-80%). Orofacial clefts (15%-20%). Tracheoesophageal fistula (15%-20%) . Neonates with CHARGE syndrome often have multiple life-threatening medical conditions. Feeding difficulties are a major cause of morbidity in all age groups. [from GeneReviews]

MedGen UID:
75567
Concept ID:
C0265354
Disease or Syndrome
12.

Finding

The result of an examination or inquiry. [from NCI]

MedGen UID:
66215
Concept ID:
C0243095
Finding
13.

Clinical finding

clinical manifestations that can be either objective when observed by a physician, or subjective when perceived by the patient. [from CRISP]

MedGen UID:
19974
Concept ID:
C0037088
Sign or Symptom
14.

Antithrombin Proteins

An endogenous family of proteins belonging to the serpin superfamily that neutralizes the action of thrombin. Six naturally occurring antithrombins have been identified and are designated by Roman numerals I to VI. Of these, Antithrombin I (see FIBRIN) and ANTITHROMBIN III appear to be of major importance. [from MeSH]

MedGen UID:
422377
Concept ID:
C2936528
Pharmacologic Substance
15.

Atenativ

MedGen UID:
303933
Concept ID:
C1448439
Pharmacologic Substance
16.

MedGen UID:
147194
Concept ID:
C0700894
17.

MedGen UID:
136413
Concept ID:
C0651143
18.

Serpin

Irreversible serine proteinase inhibitors that exert their action on peptidases. Serpins can be localized inside, or outside of the cell, and are found in all groups of organisms with the exception of fungi. In human plasma, serpins represent approximately 2% of the total protein present. [from NCI]

MedGen UID:
48634
Concept ID:
C0036764
Pharmacologic Substance
19.

Polysaccharide

A large carbohydrate molecule. It contains many small sugar molecules that are joined chemically. [from NCI]

MedGen UID:
46014
Concept ID:
C0032594
Pharmacologic Substance
20.

alpha-Heparin

MedGen UID:
43238
Concept ID:
C0085776
Pharmacologic Substance

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