Display Settings:

Format
Items per page

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 1 to 20 of 45

1.

leukemia

A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006) [from MeSH]

MedGen UID:
9725
Concept ID:
C0023418
Neoplastic Process
2.

Paroxysmal nocturnal hemoglobinuria

Paroxysmal nocturnal hemoglobinuria (PNH) is an uncommon acquired hemolytic anemia that often manifests with hemoglobinuria, abdominal pain, smooth muscle dystonias, fatigue, and thrombosis. The disease results from the expansion of hematopoietic stem cells harboring a mutation in the PIGA gene, which encodes a protein required for the biosynthesis of glycosylphosphatidylinositol (GPI), a lipid moiety that attaches dozens of proteins to the cell surface. Thus, PNH cells are deficient in cell surface GPI-anchored proteins. This deficiency on erythrocytes leads to intravascular hemolysis, since certain GPI-anchored proteins (i.e., CD55 (125240) and CD59 (107271)) normally function as complement regulators. Free hemoglobin released from intravascular hemolysis leads to circulating nitrous oxide depletion and is responsible for many of the clinical manifestations of PNH, including fatigue, erectile dysfunction, esophageal spasm, and thrombosis (review by Brodsky, 2008). Genetic Heterogeneity of Paroxysmal Nocturnal Hemoglobinuria See also PNH2 (615399), which may be caused by germline and somatic mutation in the PIGT gene (610272) on chromosome 20q13. [from OMIM]

MedGen UID:
7471
Concept ID:
C0024790
Disease or Syndrome
3.

Hemoglobinuria

A disorder characterized by laboratory test results that indicate the presence of free hemoglobin in the urine. [from NCI]

MedGen UID:
6792
Concept ID:
C0019048
Disease or Syndrome
4.

Chronic myelogenous leukemia

A myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. [from HPO]

MedGen UID:
505815
Concept ID:
CN004875
Finding
5.

Paroxysmal nocturnal hemoglobinuria

MedGen UID:
505694
Concept ID:
CN004264
Finding
6.

Leukemia

A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. [from HPO]

MedGen UID:
505002
Concept ID:
CN001727
Finding
7.

Error occurred: cannot get document summary

ID:
449933

8.

Error occurred: cannot get document summary

ID:
449932

9.

Error occurred: cannot get document summary

ID:
449931

10.

Error occurred: cannot get document summary

ID:
449930

11.

Error occurred: cannot get document summary

ID:
449929

12.

Error occurred: cannot get document summary

ID:
449928

13.

Error occurred: cannot get document summary

ID:
449927

14.

Error occurred: cannot get document summary

ID:
449926

15.

Error occurred: cannot get document summary

ID:
449925

16.

Error occurred: cannot get document summary

ID:
449924

17.

Error occurred: cannot get document summary

ID:
449635

18.

Error occurred: cannot get document summary

ID:
449634

19.

Error occurred: cannot get document summary

ID:
449633

20.

Error occurred: cannot get document summary

ID:
449632

Display Settings:

Format
Items per page

Send to:

Choose Destination

Supplemental Content

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...