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Results: 15

1.

Opiate agonist

A substance used to treat moderate to severe pain. Opioids are like opiates, such as morphine and codeine, but are not made from opium. Opioids bind to opioid receptors in the central nervous system. An opioid is a type of alkaloid. [from NCI]

MedGen UID:
66892
Concept ID:
C0242402
Pharmacologic Substance
2.

Oxycodone

A semi-synthetic, morphine-like opioid alkaloid with analgesic activity. Oxycodone exerts its analgesic activity by binding to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids. Binding of the opiate receptor stimulates the exchange of GTP for GDP on the G-protein complex and inhibits adenylate cyclase, thereby preventing cAMP production. Subsequently, the release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited. Oxycodone also inhibits the release of vasopressin, somatostatin, insulin, and glucagon. In addition, oxycodone closes N-type voltage-gated calcium channels and opens G-protein-coupled inwardly rectifying potassium channels resulting in hyperpolarization and reduction of neuronal excitability. [from NCI]

MedGen UID:
18249
Concept ID:
C0030049
Pharmacologic Substance
3.

Opana

MedGen UID:
314604
Concept ID:
C1723005
Pharmacologic Substance
4.

Oxiconum

MedGen UID:
196435
Concept ID:
C0729155
Pharmacologic Substance
5.

Ardinex

MedGen UID:
196433
Concept ID:
C0729140
Pharmacologic Substance
6.

Pancodine

MedGen UID:
182991
Concept ID:
C0917856
Pharmacologic Substance
7.

Eucodal

MedGen UID:
182989
Concept ID:
C0917854
Pharmacologic Substance
8.

Dihydrone

MedGen UID:
152648
Concept ID:
C0729152
Pharmacologic Substance
9.

Oxycontin

A controlled-release form of oxycodone. [from MeSH]

MedGen UID:
152503
Concept ID:
C0722364
Pharmacologic Substance
10.

Numorphan

MedGen UID:
148086
Concept ID:
C0733819
Pharmacologic Substance
11.

Oxymorphone

An opioid analgesic with actions and uses similar to those of MORPHINE, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092) [from MeSH]

MedGen UID:
14560
Concept ID:
C0030073
Pharmacologic Substance
12.

Theocodin

MedGen UID:
10554
Concept ID:
C0030272
Pharmacologic Substance
13.

Isocodeine

MedGen UID:
9566
Concept ID:
C0022162
Pharmacologic Substance
14.

Opioid abuse

MedGen UID:
508001
Concept ID:
C0029095
Mental or Behavioral Dysfunction
15.

noroxymorphone

MedGen UID:
385581
Concept ID:
C2351392
Pharmacologic Substance

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