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Rabies

MedGen UID:
48308
•Concept ID:
C0034494
•
Disease or Syndrome
Synonym: Lyssa
SNOMED CT: Rabies (14168008); Hydrophobia (14168008); Lyssa (14168008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019173
Orphanet: ORPHA770

Definition

Rabies is a viral zoonosis leading to a fatal encephalopathy if not treated. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRabies
Follow this link to review classifications for Rabies in Orphanet.

Professional guidelines

PubMed

Hyperimmune Globulins for the Management of Infectious Diseases.
Pati I, Cruciani M, Candura F, Massari MS, Piccinini V, Masiello F, Profili S, De Fulvio L, Pupella S, De Angelis V
Viruses 2023 Jul 13;15(7) doi: 10.3390/v15071543. PMID: 37515229Free PMC Article
Management and treatment of animal bites.
Hurt JB, Maday KR
JAAPA 2018 Apr;31(4):27-31. doi: 10.1097/01.JAA.0000531049.59137.cd. PMID: 30973531
Human rabies: neuropathogenesis, diagnosis, and management.
Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J
Lancet Neurol 2013 May;12(5):498-513. doi: 10.1016/S1474-4422(13)70038-3. PMID: 23602163

Recent clinical studies

Etiology

Cat rabies in Brazil: a growing One Health concern.
de Lima JS, Mori E, Kmetiuk LB, Biondo LM, Brandão PE, Biondo AW, Maiorka PC
Front Public Health 2023;11:1210203. Epub 2023 Jul 19 doi: 10.3389/fpubh.2023.1210203. PMID: 37538269Free PMC Article
Human rabies despite post-exposure prophylaxis: a systematic review of fatal breakthrough infections after zoonotic exposures.
Whitehouse ER, Mandra A, Bonwitt J, Beasley EA, Taliano J, Rao AK
Lancet Infect Dis 2023 May;23(5):e167-e174. Epub 2022 Dec 16 doi: 10.1016/S1473-3099(22)00641-7. PMID: 36535276
Rabies: who should care?
Baker HJ, Martin DR, Gross AL, Chamorro MF, Naskou MC, Johnson AK, Brock KV, Van Kampen KR, Willoughby RE
J Am Vet Med Assoc 2022 Dec 7;261(4):592-596. doi: 10.2460/javma.22.09.0420. PMID: 36476414
Epidemiology of Rabies and Current US Vaccine Guidelines.
Liu C, Cahill JD
R I Med J (2013) 2020 Aug 3;103(6):51-53. PMID: 32752569
Rabies pretravel vaccination.
Gautret P, Parola P
Curr Opin Infect Dis 2012 Oct;25(5):500-6. doi: 10.1097/QCO.0b013e3283567b35. PMID: 22825289

Diagnosis

Canine rabies: An epidemiological significance, pathogenesis, diagnosis, prevention, and public health issues.
Kumar A, Bhatt S, Kumar A, Rana T
Comp Immunol Microbiol Infect Dis 2023 Jun;97:101992. Epub 2023 May 9 doi: 10.1016/j.cimid.2023.101992. PMID: 37229956
Rabies.
Jin J
JAMA 2023 Jan 24;329(4):350. doi: 10.1001/jama.2022.22254. PMID: 36692559
Rabies: a medical perspective.
Jackson AC
Rev Sci Tech 2018 Aug;37(2):569-580. doi: 10.20506/rst.37.2.2825. PMID: 30747124
Human rabies: neuropathogenesis, diagnosis, and management.
Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J
Lancet Neurol 2013 May;12(5):498-513. doi: 10.1016/S1474-4422(13)70038-3. PMID: 23602163
Rabies.
Hemachudha T, Phuapradit P
Curr Opin Neurol 1997 Jun;10(3):260-7. doi: 10.1097/00019052-199706000-00016. PMID: 9229136

Therapy

Antiviral mechanisms of two broad-spectrum monoclonal antibodies for rabies prophylaxis and therapy.
Zorzan M, Castellan M, Gasparotto M, Dias de Melo G, Zecchin B, Leopardi S, Chen A, Rosato A, Angelini A, Bourhy H, Corti D, Cendron L, De Benedictis P
Front Immunol 2023;14:1186063. Epub 2023 Aug 10 doi: 10.3389/fimmu.2023.1186063. PMID: 37638057Free PMC Article
Efficacy and immunogenicity of R21/Matrix-M vaccine against clinical malaria after 2 years' follow-up in children in Burkina Faso: a phase 1/2b randomised controlled trial.
Datoo MS, Natama HM, Somé A, Bellamy D, Traoré O, Rouamba T, Tahita MC, Ido NFA, Yameogo P, Valia D, Millogo A, Ouedraogo F, Soma R, Sawadogo S, Sorgho F, Derra K, Rouamba E, Ramos-Lopez F, Cairns M, Provstgaard-Morys S, Aboagye J, Lawrie A, Roberts R, Valéa I, Sorgho H, Williams N, Glenn G, Fries L, Reimer J, Ewer KJ, Shaligram U, Hill AVS, Tinto H
Lancet Infect Dis 2022 Dec;22(12):1728-1736. Epub 2022 Sep 7 doi: 10.1016/S1473-3099(22)00442-X. PMID: 36087586
Rabies.
Gelbart D
JAAPA 2019 Oct;32(10):46-47. doi: 10.1097/01.JAA.0000580572.87216.17. PMID: 31567742
Preface.
Fooks AR
Vaccine 2019 Aug 2;37(33):4659. Epub 2019 Jul 6 doi: 10.1016/j.vaccine.2019.07.006. PMID: 31288995
Therapy of human rabies.
Jackson AC
Adv Virus Res 2011;79:365-75. doi: 10.1016/B978-0-12-387040-7.00017-2. PMID: 21601055

Prognosis

Efficacy and immunogenicity of R21/Matrix-M vaccine against clinical malaria after 2 years' follow-up in children in Burkina Faso: a phase 1/2b randomised controlled trial.
Datoo MS, Natama HM, Somé A, Bellamy D, Traoré O, Rouamba T, Tahita MC, Ido NFA, Yameogo P, Valia D, Millogo A, Ouedraogo F, Soma R, Sawadogo S, Sorgho F, Derra K, Rouamba E, Ramos-Lopez F, Cairns M, Provstgaard-Morys S, Aboagye J, Lawrie A, Roberts R, Valéa I, Sorgho H, Williams N, Glenn G, Fries L, Reimer J, Ewer KJ, Shaligram U, Hill AVS, Tinto H
Lancet Infect Dis 2022 Dec;22(12):1728-1736. Epub 2022 Sep 7 doi: 10.1016/S1473-3099(22)00442-X. PMID: 36087586
Global burden and trends of neglected tropical diseases from 1990 to 2019.
Lin Y, Fang K, Zheng Y, Wang HL, Wu J
J Travel Med 2022 May 31;29(3) doi: 10.1093/jtm/taac031. PMID: 35238925
Infectious diseases in children and adolescents in China: analysis of national surveillance data from 2008 to 2017.
Dong Y, Wang L, Burgner DP, Miller JE, Song Y, Ren X, Li Z, Xing Y, Ma J, Sawyer SM, Patton GC
BMJ 2020 Apr 2;369:m1043. doi: 10.1136/bmj.m1043. PMID: 32241761Free PMC Article
Dog and cat bites.
Ellis R, Ellis C
Am Fam Physician 2014 Aug 15;90(4):239-43. PMID: 25250997
Rabies.
Hemachudha T, Phuapradit P
Curr Opin Neurol 1997 Jun;10(3):260-7. doi: 10.1097/00019052-199706000-00016. PMID: 9229136

Clinical prediction guides

Neuroimmunology of rabies: New insights into an ancient disease.
Bastos V, Pacheco V, Rodrigues ÉDL, Moraes CNS, Nóbile AL, Fonseca DLM, Souza KBS, do Vale FYN, Filgueiras IS, Schimke LF, Giil LM, Moll G, Cabral-Miranda G, Ochs HD, Vasconcelos PFDC, de Melo GD, Bourhy H, Casseb LMN, Cabral-Marques O
J Med Virol 2023 Oct;95(10):e29042. doi: 10.1002/jmv.29042. PMID: 37885152
Spatial ecology of translocated raccoons.
Hill JE, Helton JL, Chipman RB, Gilbert AT, Beasley JC, Dharmarajan G, Rhodes OE
Sci Rep 2023 Jun 27;13(1):10447. doi: 10.1038/s41598-023-37323-6. PMID: 37369730Free PMC Article
Extracellular Vesicle-Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models.
Yang L, Han B, Zhang Z, Wang S, Bai Y, Zhang Y, Tang Y, Du L, Xu L, Wu F, Zuo L, Chen X, Lin Y, Liu K, Ye Q, Chen B, Li B, Tang T, Wang Y, Shen L, Wang G, Ju M, Yuan M, Jiang W, Zhang JH, Hu G, Wang J, Yao H
Circulation 2020 Aug 11;142(6):556-574. Epub 2020 May 22 doi: 10.1161/CIRCULATIONAHA.120.045765. PMID: 32441115
Rabies, rabies vaccine, and renal failure: Clinical issues.
Sriwijitalai W, Wiwanitkit V
Saudi J Kidney Dis Transpl 2019 May-Jun;30(3):560-563. doi: 10.4103/1319-2442.261327. PMID: 31249218
Rabies diagnosis.
Barrat J, Picard-Meyer E, Cliquet F
Dev Biol (Basel) 2006;125:71-7. PMID: 16878462

Recent systematic reviews

Rabies in Southeast Asia: a systematic review of its incidence, risk factors and mortality.
Jane Ling MY, Halim AFNA, Ahmad D, Ramly N, Hassan MR, Syed Abdul Rahim SS, Saffree Jeffree M, Omar A, Hidrus A
BMJ Open 2023 May 10;13(5):e066587. doi: 10.1136/bmjopen-2022-066587. PMID: 37164462Free PMC Article
Human rabies despite post-exposure prophylaxis: a systematic review of fatal breakthrough infections after zoonotic exposures.
Whitehouse ER, Mandra A, Bonwitt J, Beasley EA, Taliano J, Rao AK
Lancet Infect Dis 2023 May;23(5):e167-e174. Epub 2022 Dec 16 doi: 10.1016/S1473-3099(22)00641-7. PMID: 36535276
Immunogenicity after pre- and post-exposure rabies vaccination: A systematic review and dose-response meta-analysis.
Xu C, Lau CL, Clark J, Rafferty AC, Mills DJ, Ramsey L, Gilbert B, Doi SAR, Furuya-Kanamori L
Vaccine 2021 Feb 12;39(7):1044-1050. Epub 2021 Jan 18 doi: 10.1016/j.vaccine.2021.01.023. PMID: 33478786
Pre-exposure rabies prophylaxis: a systematic review.
Kessels JA, Recuenco S, Navarro-Vela AM, Deray R, Vigilato M, Ertl H, Durrheim D, Rees H, Nel LH, Abela-Ridder B, Briggs D
Bull World Health Organ 2017 Mar 1;95(3):210-219C. Epub 2016 Nov 25 doi: 10.2471/BLT.16.173039. PMID: 28250534Free PMC Article
Epidemiology, Impact and Control of Rabies in Nepal: A Systematic Review.
Devleesschauwer B, Aryal A, Sharma BK, Ale A, Declercq A, Depraz S, Gaire TN, Gongal G, Karki S, Pandey BD, Pun SB, Duchateau L, Dorny P, Speybroeck N
PLoS Negl Trop Dis 2016 Feb;10(2):e0004461. Epub 2016 Feb 12 doi: 10.1371/journal.pntd.0004461. PMID: 26871689Free PMC Article

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