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sodium citrate

MedGen UID:
56950
Concept ID:
C0142825
Pharmacologic Substance
Synonyms: Albright's Solution; Citrate sodium; E331 - Sodium citrate; Modified Shohl's Solution; Monosodium citrate; SODIUM CITRATE; Sodium Citrate; Sodium citrate; Sodium citrate product
SNOMED CT: E331 - Sodium citrate (45923000); Sodium citrate product (45923000); Sodium citrate (412546005); Sodium citrate (412547001); Monosodium citrate (412546005); Citrate sodium (412546005); Sodium citrate (45923000)
 

Definition

The sodium salt form of citrate with alkalinizing property. Upon absorption, sodium citrate dissociate and causes increased plasma bicarbonate concentration, thereby buffer excess H+, raise blood pH and reverse the clinical manifestations of acidosis. Furthermore, increased free sodium load could foster intravascular blood volume, and facilitate excretion of bicarbonate compounds and result in anti-urolithic effect. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=361795&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=361795&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62075" NCI Thesaurus) [from PDQ]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGsodium citrate

Recent clinical studies

Etiology

Yon CK, Low CL
Am J Health Syst Pharm 2013 Jan 15;70(2):131-6. doi: 10.2146/ajhp120300. PMID: 23292266
Timpmann S, Burk A, Medijainen L, Tamm M, Kreegipuu K, Vähi M, Unt E, Oöpik V
Appl Physiol Nutr Metab 2012 Dec;37(6):1028-37. Epub 2012 Aug 8 doi: 10.1139/h2012-089. [Epub ahead of print] PMID: 22871128
Cavassim R, Leite FR, Zandim DL, Dantas AA, Rached RS, Sampaio JE
J Appl Oral Sci 2012 May-Jun;20(3):376-83. PMID: 22858707Free PMC Article
Hermite L, Quenot JP, Nadji A, Barbar SD, Charles PE, Hamet M, Jacquiot N, Ghiringhelli F, Freysz M
Intensive Care Med 2012 Feb;38(2):279-85. Epub 2011 Nov 29 doi: 10.1007/s00134-011-2422-y. [Epub ahead of print] PMID: 22124771
Power A, Duncan N, Singh SK, Brown W, Dalby E, Edwards C, Lynch K, Prout V, Cairns T, Griffith M, McLean A, Palmer A, Taube D
Am J Kidney Dis 2009 Jun;53(6):1034-41. Epub 2009 Apr 25 doi: 10.1053/j.ajkd.2009.01.259. [Epub ahead of print] PMID: 19394731

Diagnosis

Lima-Oliveira G, Lippi G, Salvagno GL, Montagnana M, Picheth G, Guidi GC
Blood Coagul Fibrinolysis 2013 Apr;24(3):252-5. doi: 10.1097/MBC.0b013e32835b72ea. PMID: 23160241
Freese C, Uboldi C, Gibson MI, Unger RE, Weksler BB, Romero IA, Couraud PO, Kirkpatrick CJ
Part Fibre Toxicol 2012 Jul 3;9:23. doi: 10.1186/1743-8977-9-23. [Epub ahead of print] PMID: 22759355Free PMC Article
De Laat B, Derksen RH, Reber G, Musial J, Swadzba J, Bozic B, Cucnik S, Regnault V, Forastiero R, Woodhams BJ, De Groot PG
J Thromb Haemost 2011 Jan;9(1):149-53. doi: 10.1111/j.1538-7836.2010.04068.x. PMID: 20874780
Patnaik N, Ratho RK, Mishra B, Chakraborty A, Sakhuja VK
J Virol Methods 2008 Feb;147(2):319-21. Epub 2007 Nov 9 doi: 10.1016/j.jviromet.2007.09.019. [Epub ahead of print] PMID: 17996957
Cardinal P, Allan J, Pham B, Hindmarsh T, Jones G, Delisle S
Crit Care Med 2000 May;28(5):1388-92. PMID: 10834683

Therapy

Yon CK, Low CL
Am J Health Syst Pharm 2013 Jan 15;70(2):131-6. doi: 10.2146/ajhp120300. PMID: 23292266
Timpmann S, Burk A, Medijainen L, Tamm M, Kreegipuu K, Vähi M, Unt E, Oöpik V
Appl Physiol Nutr Metab 2012 Dec;37(6):1028-37. Epub 2012 Aug 8 doi: 10.1139/h2012-089. [Epub ahead of print] PMID: 22871128
Cavassim R, Leite FR, Zandim DL, Dantas AA, Rached RS, Sampaio JE
J Appl Oral Sci 2012 May-Jun;20(3):376-83. PMID: 22858707Free PMC Article
LaPlante KL, Woodmansee S, Mermel LA
Am J Health Syst Pharm 2012 Aug 15;69(16):1405-9. doi: 10.2146/ajhp110256. PMID: 22855107
Hermite L, Quenot JP, Nadji A, Barbar SD, Charles PE, Hamet M, Jacquiot N, Ghiringhelli F, Freysz M
Intensive Care Med 2012 Feb;38(2):279-85. Epub 2011 Nov 29 doi: 10.1007/s00134-011-2422-y. [Epub ahead of print] PMID: 22124771

Prognosis

Sumaya W, Daly RL, Mehra S, Dhutia AJ, Howgego KE, Ecob R, Judge HM, Morton AC, Storey RF
Thromb Haemost 2013 Mar;109(3):550-5. Epub 2013 Jan 10 doi: 10.1160/TH12-10-0718. [Epub ahead of print] PMID: 23306859
Gosselin RC, Wu JR, Kottke-Marchant K, Peetz D, Christie DJ, Muth H, Panacek E
Thromb Res 2012 Nov;130(5):e274-8. Epub 2012 Jan 14 doi: 10.1016/j.thromres.2011.12.015. [Epub ahead of print] PMID: 22245223
Lojanapiwat B, Tanthanuch M, Pripathanont C, Ratchanon S, Srinualnad S, Taweemonkongsap T, Kanyok S, Lammongkolkul S
Int Braz J Urol 2011 Sep-Oct;37(5):611-6. PMID: 22099273
Grudzinski L, Quinan P, Kwok S, Pierratos A
Nephrol Dial Transplant 2007 Feb;22(2):471-6. Epub 2006 Oct 25 doi: 10.1093/ndt/gfl606. [Epub ahead of print] PMID: 17065193
Cardinal P, Allan J, Pham B, Hindmarsh T, Jones G, Delisle S
Crit Care Med 2000 May;28(5):1388-92. PMID: 10834683

Clinical prediction guides

Lima-Oliveira G, Lippi G, Salvagno GL, Montagnana M, Picheth G, Guidi GC
Blood Coagul Fibrinolysis 2013 Apr;24(3):252-5. doi: 10.1097/MBC.0b013e32835b72ea. PMID: 23160241
Hermite L, Quenot JP, Nadji A, Barbar SD, Charles PE, Hamet M, Jacquiot N, Ghiringhelli F, Freysz M
Intensive Care Med 2012 Feb;38(2):279-85. Epub 2011 Nov 29 doi: 10.1007/s00134-011-2422-y. [Epub ahead of print] PMID: 22124771
Goulet DR, Knee KM, King JA
Exp Eye Res 2011 Oct;93(4):371-81. Epub 2011 May 12 doi: 10.1016/j.exer.2011.04.011. [Epub ahead of print] PMID: 21600897Free PMC Article
Ponrajan A, Harrison MA, Segers JR, Lowe BK, McKeith RO, Pringle TD, Martino KG, Mulligan JH, Stelzleni AM
J Food Prot 2011 Mar;74(3):359-64. doi: 10.4315/0362-028X.JFP-10-294. PMID: 21375870
Nagaoka S, Murata S, Kimura K, Mori T, Hojo K
Lett Appl Microbiol 2010 Nov;51(5):546-51. Epub 2010 Sep 16 doi: 10.1111/j.1472-765X.2010.02932.x. [Epub ahead of print] PMID: 20849395

Recent systematic reviews

Schubert MM, Astorino TA
J Strength Cond Res 2013 Jun;27(6):1699-707. doi: 10.1519/JSC.0b013e31826cad24. PMID: 22890496
Carr AJ, Hopkins WG, Gore CJ
Sports Med 2011 Oct 1;41(10):801-14. doi: 10.2165/11591440-000000000-00000. PMID: 21923200
Smith I, Kranke P, Murat I, Smith A, O'Sullivan G, Søreide E, Spies C, in't Veld B; European Society of Anaesthesiology
Eur J Anaesthesiol 2011 Aug;28(8):556-69. doi: 10.1097/EJA.0b013e3283495ba1. PMID: 21712716
Moran JE, Ash SR; ASDIN Clinical Practice Committee
Semin Dial 2008 Sep-Oct;21(5):490-2. Epub 2008 Aug 29 doi: 10.1111/j.1525-139X.2008.00466.x. [Epub ahead of print] PMID: 18764795
McCarty MF
Med Hypotheses 2004;63(1):138-48. doi: 10.1016/j.mehy.2003.11.005. PMID: 15193367

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