Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Sudden infant death syndrome(SIDS)

MedGen UID:
52548
Concept ID:
C0038644
Disease or Syndrome
Synonyms: CAV3-Related Sudden Infant Death Syndrome; SIDS; Sudden Infant Death; Sudden Infant Death Syndrome
SNOMED CT: SIDS - Sudden infant death syndrome (51178009); Sudden infant death syndrome (51178009); Unexpected sudden death of infant (51178009); SIDS (51178009); Crib death (51178009); Cot death (51178009)
 
Gene: SCN5A
Cytogenetic location: 3p22.2
OMIM: 272120

Definition

Sudden infant death syndrome (SIDS) is a diagnosis of exclusion which should be made only after a thorough autopsy without identification of a specific cause of death (Mage and Donner, 2004). Weese-Mayer et al. (2007) provided a detailed review of genetic factors that have been implicated in SIDS. The authors concluded that SIDS represents more than 1 entity and has a heterogeneous etiology most likely involving several different genetically controlled metabolic pathways. [from OMIM]

Clinical features

Apneic episodes in infancy
MedGen UID:
501002
Concept ID:
CN005242
Finding
Recurrent episodes of apnea occurring during infancy.

Term Hierarchy

Recent clinical studies

Etiology

Studer J, Bartsch C, Haas C
Pediatr Res 2014 Jul;76(1):41-5. Epub 2014 Apr 11 doi: 10.1038/pr.2014.59. [Epub ahead of print] PMID: 24727946
Rognum IJ, Tran H, Haas EA, Hyland K, Paterson DS, Haynes RL, Broadbelt KG, Harty BJ, Mena O, Krous HF, Kinney HC
J Neuropathol Exp Neurol 2014 Feb;73(2):115-22. doi: 10.1097/NEN.0000000000000034. PMID: 24423636
Knight J, Webster V, Kemp L, Comino E
J Paediatr Child Health 2013 Dec;49(12):1025-31. Epub 2013 Jun 20 doi: 10.1111/jpc.12306. [Epub ahead of print] PMID: 23782227
Garcia AJ 3rd, Koschnitzky JE, Ramirez JM
Respir Physiol Neurobiol 2013 Nov 1;189(2):288-300. Epub 2013 Jun 2 doi: 10.1016/j.resp.2013.05.032. [Epub ahead of print] PMID: 23735486Free PMC Article
Wood AM, Pasupathy D, Pell JP, Fleming M, Smith GC
BMJ 2012 Mar 16;344:e1552. PMID: 22427307Free PMC Article

Diagnosis

Paterson DS
Respir Physiol Neurobiol 2013 Nov 1;189(2):301-14. Epub 2013 Jul 10 doi: 10.1016/j.resp.2013.07.001. [Epub ahead of print] PMID: 23851109Free PMC Article
Garcia AJ 3rd, Koschnitzky JE, Ramirez JM
Respir Physiol Neurobiol 2013 Nov 1;189(2):288-300. Epub 2013 Jun 2 doi: 10.1016/j.resp.2013.05.032. [Epub ahead of print] PMID: 23735486Free PMC Article
Yoo SH, Kim AJ, Kang SM, Lee HY, Seo JS, Kwon TJ, Yang KM
J Korean Med Sci 2013 Mar;28(3):438-42. Epub 2013 Mar 4 doi: 10.3346/jkms.2013.28.3.438. PMID: 23487503Free PMC Article
O'Leary CM, Jacoby PJ, Bartu A, D'Antoine H, Bower C
Pediatrics 2013 Mar;131(3):e770-8. Epub 2013 Feb 25 doi: 10.1542/peds.2012-1907. [Epub ahead of print] PMID: 23439895
Van Nguyen JM, Abenhaim HA
Am J Perinatol 2013 Oct;30(9):703-14. Epub 2013 Jan 5 doi: 10.1055/s-0032-1331035. [Epub ahead of print] PMID: 23292938

Therapy

Hawkes N
BMJ 2013 May 20;346:f3296. PMID: 23690509
O'Leary CM, Jacoby PJ, Bartu A, D'Antoine H, Bower C
Pediatrics 2013 Mar;131(3):e770-8. Epub 2013 Feb 25 doi: 10.1542/peds.2012-1907. [Epub ahead of print] PMID: 23439895
Van Nguyen JM, Abenhaim HA
Am J Perinatol 2013 Oct;30(9):703-14. Epub 2013 Jan 5 doi: 10.1055/s-0032-1331035. [Epub ahead of print] PMID: 23292938
Zhang K, Wang X
Leg Med (Tokyo) 2013 May;15(3):115-21. Epub 2012 Dec 6 doi: 10.1016/j.legalmed.2012.10.007. [Epub ahead of print] PMID: 23219585
Byard RW, Lee V
J Forensic Leg Med 2012 Nov;19(8):455-6. Epub 2012 Apr 27 doi: 10.1016/j.jflm.2012.04.004. [Epub ahead of print] PMID: 23084308

Prognosis

Gilbert NL, Auger N, Wilkins R, Kramer MS
Can J Public Health 2013 Mar 7;104(3):e187-92. PMID: 23823880
Evans A, Bagnall RD, Duflou J, Semsarian C
Hum Pathol 2013 Sep;44(9):1730-6. Epub 2013 Apr 25 doi: 10.1016/j.humpath.2013.01.024. [Epub ahead of print] PMID: 23623143
Andreasen C, Refsgaard L, Nielsen JB, Sajadieh A, Winkel BG, Tfelt-Hansen J, Haunsø S, Holst AG, Svendsen JH, Olesen MS
Can J Cardiol 2013 Sep;29(9):1104-9. Epub 2013 Mar 7 doi: 10.1016/j.cjca.2012.12.002. [Epub ahead of print] PMID: 23465283
Malloy MH
J Perinatol 2013 Jun;33(6):470-5. Epub 2013 Jan 3 doi: 10.1038/jp.2012.158. [Epub ahead of print] PMID: 23288251
Wood AM, Pasupathy D, Pell JP, Fleming M, Smith GC
BMJ 2012 Mar 16;344:e1552. PMID: 22427307Free PMC Article

Clinical prediction guides

Groß M, Bajanowski T, Vennemann M, Poetsch M
Int J Legal Med 2014 Jan;128(1):43-9. Epub 2013 Oct 31 doi: 10.1007/s00414-013-0928-2. [Epub ahead of print] PMID: 24173666
Paterson DS
Respir Physiol Neurobiol 2013 Nov 1;189(2):301-14. Epub 2013 Jul 10 doi: 10.1016/j.resp.2013.07.001. [Epub ahead of print] PMID: 23851109Free PMC Article
Gilbert NL, Auger N, Wilkins R, Kramer MS
Can J Public Health 2013 Mar 7;104(3):e187-92. PMID: 23823880
Evans A, Bagnall RD, Duflou J, Semsarian C
Hum Pathol 2013 Sep;44(9):1730-6. Epub 2013 Apr 25 doi: 10.1016/j.humpath.2013.01.024. [Epub ahead of print] PMID: 23623143
Wood AM, Pasupathy D, Pell JP, Fleming M, Smith GC
BMJ 2012 Mar 16;344:e1552. PMID: 22427307Free PMC Article

Recent systematic reviews

Zhang K, Wang X
Leg Med (Tokyo) 2013 May;15(3):115-21. Epub 2012 Dec 6 doi: 10.1016/j.legalmed.2012.10.007. [Epub ahead of print] PMID: 23219585
Strehle EM, Gray WK, Gopisetti S, Richardson J, McGuire J, Malone S
Acta Paediatr 2012 Jan;101(1):8-13. Epub 2011 Oct 10 doi: 10.1111/j.1651-2227.2011.02464.x. [Epub ahead of print] PMID: 21910748
Vennemann MM, Hense HW, Bajanowski T, Blair PS, Complojer C, Moon RY, Kiechl-Kohlendorfer U
J Pediatr 2012 Jan;160(1):44-8.e2. Epub 2011 Aug 24 doi: 10.1016/j.jpeds.2011.06.052. [Epub ahead of print] PMID: 21868032
Hauck FR, Thompson JM, Tanabe KO, Moon RY, Vennemann MM
Pediatrics 2011 Jul;128(1):103-10. Epub 2011 Jun 13 doi: 10.1542/peds.2010-3000. [Epub ahead of print] PMID: 21669892
Fracasso T, Vennemann M, Pfeiffer H, Bajanowski T
Am J Forensic Med Pathol 2009 Sep;30(3):231-4. doi: 10.1097/PAF.0b013e318187e0f2. PMID: 19696576

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...