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Subarachnoid hemorrhage

MedGen UID:
505121
Concept ID:
CN001937
Finding
Synonyms: Subarachnoid haemorrhage
 
HPO: HP:0002138

Definition

Hemorrhage occurring between the arachnoid mater and the pia mater. [from HPO]

Term Hierarchy

Conditions with this feature

Osler hemorrhagic telangiectasia syndrome
MedGen UID:
52657
Concept ID:
C0039445
Disease or Syndrome
Hereditary hemorrhagic telangiectasia (HHT) is characterized by the presence of multiple arteriovenous malformations (AVMs) that lack intervening capillaries and result in direct connections between arteries and veins. Although HHT is a developmental disorder and infants are occasionally severely affected, in most people the features are age-dependent and the diagnosis not suspected until adolescence or later. Small AVMs (or telangiectases) close to the surface of the skin and mucous membranes often rupture and bleed after slight trauma. The most common clinical manifestation is spontaneous and recurrent nosebleeds (epistaxis) beginning on average at age 12 years. Approximately 25% of individuals with HHT have GI bleeding, which most commonly begins after age 50 years. Large AVMs often cause symptoms when they occur in the brain, liver, or lungs; complications from bleeding or shunting may be sudden and catastrophic.
Hereditary hemorrhagic telangiectasia type 2
MedGen UID:
324960
Concept ID:
C1838163
Disease or Syndrome
Hereditary hemorrhagic telangiectasia (HHT) is characterized by the presence of multiple arteriovenous malformations (AVMs) that lack intervening capillaries and result in direct connections between arteries and veins. Although HHT is a developmental disorder and infants are occasionally severely affected, in most people the features are age-dependent and the diagnosis not suspected until adolescence or later. Small AVMs (or telangiectases) close to the surface of the skin and mucous membranes often rupture and bleed after slight trauma. The most common clinical manifestation is spontaneous and recurrent nosebleeds (epistaxis) beginning on average at age 12 years. Approximately 25% of individuals with HHT have GI bleeding, which most commonly begins after age 50 years. Large AVMs often cause symptoms when they occur in the brain, liver, or lungs; complications from bleeding or shunting may be sudden and catastrophic.
Vascular hyalinosis
MedGen UID:
376398
Concept ID:
C1848590
Disease or Syndrome
Hereditary hemorrhagic telangiectasia type 4
MedGen UID:
341824
Concept ID:
C1857688
Disease or Syndrome
Hereditary hemorrhagic telangiectasia (HHT) is characterized by the presence of multiple arteriovenous malformations (AVMs) that lack intervening capillaries and result in direct connections between arteries and veins. Although HHT is a developmental disorder and infants are occasionally severely affected, in most people the features are age-dependent and the diagnosis not suspected until adolescence or later. Small AVMs (or telangiectases) close to the surface of the skin and mucous membranes often rupture and bleed after slight trauma. The most common clinical manifestation is spontaneous and recurrent nosebleeds (epistaxis) beginning on average at age 12 years. Approximately 25% of individuals with HHT have GI bleeding, which most commonly begins after age 50 years. Large AVMs often cause symptoms when they occur in the brain, liver, or lungs; complications from bleeding or shunting may be sudden and catastrophic.
Hyperimmunoglobulin E recurrent infection syndrome, autosomal recessive
MedGen UID:
369829
Concept ID:
C1968689
Disease or Syndrome
Autosomal dominant hyper-IgE recurrent infection syndrome (147060) is a primary immunodeficiency disorder characterized by recurrent Staphylococcus aureus skin abscesses, increased serum IgE, and abnormalities of the connective tissue, skeleton, and dentition (Buckley et al., 1972; Grimbacher et al., 1999). The autosomal recessive form shares hyper-IgE, eosinophilia, and recurrent Staphylococcal infections, but is distinguished from autosomal dominant HIES by the lack of connective tissue and skeletal involvement (Renner et al., 2004). See also TYK2 deficiency (611521), a clinically distinct disease entity that includes characteristic features of both autosomal recessive HIES and mendelian susceptibility to mycobacterial disease (MSMD; 209950) (Minegishi et al., 2006).

Recent clinical studies

Etiology

Gessler F, Mutlak H, Lamb S, Hartwich M, Adelmann M, Platz J, Konczalla J, Seifert V, Senft C
Crit Care Med 2015 Nov;43(11):2429-38. doi: 10.1097/CCM.0000000000001195. PMID: 26308429
Magni F, Pozzi M, Rota M, Vargiolu A, Citerio G
Stroke 2015 Sep;46(9):2464-9. Epub 2015 Aug 4 doi: 10.1161/STROKEAHA.115.010219. [Epub ahead of print] PMID: 26243224
van Donkelaar CE, Bakker NA, Veeger NJ, Uyttenboogaart M, Metzemaekers JD, Luijckx GJ, Groen RJ, van Dijk JM
Stroke 2015 Aug;46(8):2100-6. Epub 2015 Jun 11 doi: 10.1161/STROKEAHA.115.010037. [Epub ahead of print] PMID: 26069261
Martínez-Lizana E, Carmona-Iragui M, Alcolea D, Gómez-Choco M, Vilaplana E, Sánchez-Saudinós MB, Clarimón J, Hernández-Guillamon M, Munuera J, Gelpi E, Gómez-Anson B, de Juan-Delago M, Delgado-Mederos R, Montaner J, Ois A, Amaro S, Blesa R, Martí-Fàbregas J, Lleó A, Fortea J
J Cereb Blood Flow Metab 2015 May;35(5):710-7. Epub 2015 Mar 4 doi: 10.1038/jcbfm.2015.25. [Epub ahead of print] PMID: 25735919Free PMC Article
Heffren J, McIntosh AM, Reiter PD
Pediatr Neurol 2015 Mar;52(3):356-60. Epub 2014 Nov 11 doi: 10.1016/j.pediatrneurol.2014.11.003. [Epub ahead of print] PMID: 25585913

Diagnosis

Gessler F, Mutlak H, Lamb S, Hartwich M, Adelmann M, Platz J, Konczalla J, Seifert V, Senft C
Crit Care Med 2015 Nov;43(11):2429-38. doi: 10.1097/CCM.0000000000001195. PMID: 26308429
van Donkelaar CE, Bakker NA, Veeger NJ, Uyttenboogaart M, Metzemaekers JD, Luijckx GJ, Groen RJ, van Dijk JM
Stroke 2015 Aug;46(8):2100-6. Epub 2015 Jun 11 doi: 10.1161/STROKEAHA.115.010037. [Epub ahead of print] PMID: 26069261
de Souza ML, Vieira AC, Andrade G, Quinino S, de Fátima Leal Griz M, Azevedo-Filho HR
World Neurosurg 2015 Aug;84(2):308-13. Epub 2015 Mar 19 doi: 10.1016/j.wneu.2015.03.017. [Epub ahead of print] PMID: 25797076
Heffren J, McIntosh AM, Reiter PD
Pediatr Neurol 2015 Mar;52(3):356-60. Epub 2014 Nov 11 doi: 10.1016/j.pediatrneurol.2014.11.003. [Epub ahead of print] PMID: 25585913
Jaja BN, Lingsma H, Schweizer TA, Thorpe KE, Steyerberg EW, Macdonald RL; SAHIT collaboration
J Neurosurg 2015 Mar;122(3):644-52. Epub 2015 Jan 2 doi: 10.3171/2014.10.JNS132694. [Epub ahead of print] PMID: 25554825

Therapy

Xie Y, Liu W, Zhang X, Wang L, Xu L, Xiong Y, Yang L, Sang H, Ye R, Liu X
Crit Care Med 2015 Oct;43(10):e440-9. doi: 10.1097/CCM.0000000000001193. PMID: 26181220
de Oliveira Manoel AL, Jaja BN, Germans MR, Yan H, Qian W, Kouzmina E, Marotta TR, Turkel-Parrella D, Schweizer TA, Macdonald RL; SAHIT collaborators
Stroke 2015 Jul;46(7):1826-31. Epub 2015 May 14 doi: 10.1161/STROKEAHA.115.008728. [Epub ahead of print] PMID: 25977276
Martínez-Lizana E, Carmona-Iragui M, Alcolea D, Gómez-Choco M, Vilaplana E, Sánchez-Saudinós MB, Clarimón J, Hernández-Guillamon M, Munuera J, Gelpi E, Gómez-Anson B, de Juan-Delago M, Delgado-Mederos R, Montaner J, Ois A, Amaro S, Blesa R, Martí-Fàbregas J, Lleó A, Fortea J
J Cereb Blood Flow Metab 2015 May;35(5):710-7. Epub 2015 Mar 4 doi: 10.1038/jcbfm.2015.25. [Epub ahead of print] PMID: 25735919Free PMC Article
Heffren J, McIntosh AM, Reiter PD
Pediatr Neurol 2015 Mar;52(3):356-60. Epub 2014 Nov 11 doi: 10.1016/j.pediatrneurol.2014.11.003. [Epub ahead of print] PMID: 25585913
Jaja BN, Lingsma H, Schweizer TA, Thorpe KE, Steyerberg EW, Macdonald RL; SAHIT collaboration
J Neurosurg 2015 Mar;122(3):644-52. Epub 2015 Jan 2 doi: 10.3171/2014.10.JNS132694. [Epub ahead of print] PMID: 25554825

Prognosis

Gessler F, Mutlak H, Lamb S, Hartwich M, Adelmann M, Platz J, Konczalla J, Seifert V, Senft C
Crit Care Med 2015 Nov;43(11):2429-38. doi: 10.1097/CCM.0000000000001195. PMID: 26308429
Magni F, Pozzi M, Rota M, Vargiolu A, Citerio G
Stroke 2015 Sep;46(9):2464-9. Epub 2015 Aug 4 doi: 10.1161/STROKEAHA.115.010219. [Epub ahead of print] PMID: 26243224
van Donkelaar CE, Bakker NA, Veeger NJ, Uyttenboogaart M, Metzemaekers JD, Luijckx GJ, Groen RJ, van Dijk JM
Stroke 2015 Aug;46(8):2100-6. Epub 2015 Jun 11 doi: 10.1161/STROKEAHA.115.010037. [Epub ahead of print] PMID: 26069261
Martínez-Lizana E, Carmona-Iragui M, Alcolea D, Gómez-Choco M, Vilaplana E, Sánchez-Saudinós MB, Clarimón J, Hernández-Guillamon M, Munuera J, Gelpi E, Gómez-Anson B, de Juan-Delago M, Delgado-Mederos R, Montaner J, Ois A, Amaro S, Blesa R, Martí-Fàbregas J, Lleó A, Fortea J
J Cereb Blood Flow Metab 2015 May;35(5):710-7. Epub 2015 Mar 4 doi: 10.1038/jcbfm.2015.25. [Epub ahead of print] PMID: 25735919Free PMC Article
Jaja BN, Lingsma H, Schweizer TA, Thorpe KE, Steyerberg EW, Macdonald RL; SAHIT collaboration
J Neurosurg 2015 Mar;122(3):644-52. Epub 2015 Jan 2 doi: 10.3171/2014.10.JNS132694. [Epub ahead of print] PMID: 25554825

Clinical prediction guides

Gessler F, Mutlak H, Lamb S, Hartwich M, Adelmann M, Platz J, Konczalla J, Seifert V, Senft C
Crit Care Med 2015 Nov;43(11):2429-38. doi: 10.1097/CCM.0000000000001195. PMID: 26308429
Magni F, Pozzi M, Rota M, Vargiolu A, Citerio G
Stroke 2015 Sep;46(9):2464-9. Epub 2015 Aug 4 doi: 10.1161/STROKEAHA.115.010219. [Epub ahead of print] PMID: 26243224
Xie Y, Liu W, Zhang X, Wang L, Xu L, Xiong Y, Yang L, Sang H, Ye R, Liu X
Crit Care Med 2015 Oct;43(10):e440-9. doi: 10.1097/CCM.0000000000001193. PMID: 26181220
Heffren J, McIntosh AM, Reiter PD
Pediatr Neurol 2015 Mar;52(3):356-60. Epub 2014 Nov 11 doi: 10.1016/j.pediatrneurol.2014.11.003. [Epub ahead of print] PMID: 25585913
Jaja BN, Lingsma H, Schweizer TA, Thorpe KE, Steyerberg EW, Macdonald RL; SAHIT collaboration
J Neurosurg 2015 Mar;122(3):644-52. Epub 2015 Jan 2 doi: 10.3171/2014.10.JNS132694. [Epub ahead of print] PMID: 25554825

Recent systematic reviews

Laban KG, Vergouwen MD, Dijkhuizen RM, Sena ES, Macleod MR, Rinkel GJ, van der Worp HB
J Cereb Blood Flow Metab 2015 Jul;35(7):1085-9. Epub 2015 May 6 doi: 10.1038/jcbfm.2015.89. [Epub ahead of print] PMID: 25944590Free PMC Article
Young AM, Karri SK, Helmy A, Budohoski KP, Kirollos RW, Bulters DO, Kirkpatrick PJ, Ogilvy CS, Trivedi RA
World Neurosurg 2015 Jul;84(1):28-35. Epub 2015 Feb 18 doi: 10.1016/j.wneu.2015.02.004. [Epub ahead of print] PMID: 25701766
Boluijt J, Meijers JC, Rinkel GJ, Vergouwen MD
J Cereb Blood Flow Metab 2015 May;35(5):724-33. Epub 2015 Feb 18 doi: 10.1038/jcbfm.2015.13. [Epub ahead of print] PMID: 25690473Free PMC Article
Jaja BN, Lingsma H, Schweizer TA, Thorpe KE, Steyerberg EW, Macdonald RL; SAHIT collaboration
J Neurosurg 2015 Mar;122(3):644-52. Epub 2015 Jan 2 doi: 10.3171/2014.10.JNS132694. [Epub ahead of print] PMID: 25554825
Torné R, Rodríguez-Hernández A, Bernard T, Arikan Abelló F, Vilalta Castan J, Sahuquillo J
Clin Neurol Neurosurg 2015 Jan;128:17-24. Epub 2014 Nov 4 doi: 10.1016/j.clineuro.2014.10.018. [Epub ahead of print] PMID: 25462090

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