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everolimus

MedGen UID:
107432
Concept ID:
C0541315
Pharmacologic Substance
Synonyms: 40-O-(2-hydroxyethyl)-rapamycin; SDZ RAD; SDZ-RAD
SNOMED CT: Everolimus (428698007); Everolimus (428127005)
 

Definition

A derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production. (NCI05) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGeverolimus

Recent clinical studies

Etiology

Zhu AX, Kudo M, Assenat E, Cattan S, Kang YK, Lim HY, Poon RT, Blanc JF, Vogel A, Chen CL, Dorval E, Peck-Radosavljevic M, Santoro A, Daniele B, Furuse J, Jappe A, Perraud K, Anak O, Sellami DB, Chen LT
JAMA 2014 Jul 2;312(1):57-67. doi: 10.1001/jama.2014.7189. PMID: 25058218
André F, O'Regan R, Ozguroglu M, Toi M, Xu B, Jerusalem G, Masuda N, Wilks S, Arena F, Isaacs C, Yap YS, Papai Z, Lang I, Armstrong A, Lerzo G, White M, Shen K, Litton J, Chen D, Zhang Y, Ali S, Taran T, Gianni L
Lancet Oncol 2014 May;15(6):580-91. Epub 2014 Apr 14 doi: 10.1016/S1470-2045(14)70138-X. [Epub ahead of print] PMID: 24742739
Kato R, Obara W, Matsuura T, Kato Y, Iwasaki K, Fujioka T
Jpn J Clin Oncol 2014 May;44(5):479-85. Epub 2014 Mar 30 doi: 10.1093/jjco/hyu018. [Epub ahead of print] PMID: 24688083
Robertsen I, Asberg A, Granseth T, Vethe NT, Akhlaghi F, Ghareeb M, Molden E, Reier-Nilsen M, Holdaas H, Midtvedt K
Transplantation 2014 Jun 27;97(12):1266-71. doi: 10.1097/01.TP.0000443225.66960.7e. PMID: 24521776Free PMC Article
Ravaud A, Urva SR, Grosch K, Cheung WK, Anak O, Sellami DB
Eur J Cancer 2014 Feb;50(3):486-95. Epub 2013 Dec 9 doi: 10.1016/j.ejca.2013.11.022. [Epub ahead of print] PMID: 24332451

Diagnosis

André F, O'Regan R, Ozguroglu M, Toi M, Xu B, Jerusalem G, Masuda N, Wilks S, Arena F, Isaacs C, Yap YS, Papai Z, Lang I, Armstrong A, Lerzo G, White M, Shen K, Litton J, Chen D, Zhang Y, Ali S, Taran T, Gianni L
Lancet Oncol 2014 May;15(6):580-91. Epub 2014 Apr 14 doi: 10.1016/S1470-2045(14)70138-X. [Epub ahead of print] PMID: 24742739
Mihajlović J, Pechlivanoglou P, Sabo A, Tomić Z, Postma MJ
Clin Ther 2013 Dec;35(12):1909-22. Epub 2013 Nov 13 doi: 10.1016/j.clinthera.2013.10.004. [Epub ahead of print] PMID: 24238790
Onuma Y, Dudek D, Thuesen L, Webster M, Nieman K, Garcia-Garcia HM, Ormiston JA, Serruys PW
JACC Cardiovasc Interv 2013 Oct;6(10):999-1009. doi: 10.1016/j.jcin.2013.05.017. PMID: 24156961
Kim SJ, Kang HJ, Kim JS, Eom HS, Huh J, Ko YH, Lee J, Yim DS, Lee SY, Park WS, Yang WI, Lee SS, Suh C, Kim WS
Invest New Drugs 2013 Dec;31(6):1514-21. Epub 2013 Aug 24 doi: 10.1007/s10637-013-0015-z. [Epub ahead of print] PMID: 23975510
Krueger DA, Wilfong AA, Holland-Bouley K, Anderson AE, Agricola K, Tudor C, Mays M, Lopez CM, Kim MO, Franz DN
Ann Neurol 2013 Nov;74(5):679-87. Epub 2013 Sep 10 doi: 10.1002/ana.23960. [Epub ahead of print] PMID: 23798472

Therapy

Zhu AX, Kudo M, Assenat E, Cattan S, Kang YK, Lim HY, Poon RT, Blanc JF, Vogel A, Chen CL, Dorval E, Peck-Radosavljevic M, Santoro A, Daniele B, Furuse J, Jappe A, Perraud K, Anak O, Sellami DB, Chen LT
JAMA 2014 Jul 2;312(1):57-67. doi: 10.1001/jama.2014.7189. PMID: 25058218
André F, O'Regan R, Ozguroglu M, Toi M, Xu B, Jerusalem G, Masuda N, Wilks S, Arena F, Isaacs C, Yap YS, Papai Z, Lang I, Armstrong A, Lerzo G, White M, Shen K, Litton J, Chen D, Zhang Y, Ali S, Taran T, Gianni L
Lancet Oncol 2014 May;15(6):580-91. Epub 2014 Apr 14 doi: 10.1016/S1470-2045(14)70138-X. [Epub ahead of print] PMID: 24742739
Kato R, Obara W, Matsuura T, Kato Y, Iwasaki K, Fujioka T
Jpn J Clin Oncol 2014 May;44(5):479-85. Epub 2014 Mar 30 doi: 10.1093/jjco/hyu018. [Epub ahead of print] PMID: 24688083
Robertsen I, Asberg A, Granseth T, Vethe NT, Akhlaghi F, Ghareeb M, Molden E, Reier-Nilsen M, Holdaas H, Midtvedt K
Transplantation 2014 Jun 27;97(12):1266-71. doi: 10.1097/01.TP.0000443225.66960.7e. PMID: 24521776Free PMC Article
Ravaud A, Urva SR, Grosch K, Cheung WK, Anak O, Sellami DB
Eur J Cancer 2014 Feb;50(3):486-95. Epub 2013 Dec 9 doi: 10.1016/j.ejca.2013.11.022. [Epub ahead of print] PMID: 24332451

Prognosis

Ferté C, Koscielny S, Albiges L, Rocher L, Soria JC, Iacovelli R, Loriot Y, Fizazi K, Escudier B
Eur Urol 2014 Apr;65(4):713-20. Epub 2013 Aug 15 doi: 10.1016/j.eururo.2013.08.010. [Epub ahead of print] PMID: 23993162
Mihajlović J, Pechlivanoglou P, Sabo A, Tomić Z, Postma MJ
Clin Ther 2013 Dec;35(12):1909-22. Epub 2013 Nov 13 doi: 10.1016/j.clinthera.2013.10.004. [Epub ahead of print] PMID: 24238790
Onuma Y, Dudek D, Thuesen L, Webster M, Nieman K, Garcia-Garcia HM, Ormiston JA, Serruys PW
JACC Cardiovasc Interv 2013 Oct;6(10):999-1009. doi: 10.1016/j.jcin.2013.05.017. PMID: 24156961
Cooper M, Wiseman AC, Zibari G, McCague K, Kim Y, Geissler F, Nashan B
Clin Transplant 2013 Nov-Dec;27(6):E625-35. Epub 2013 Sep 6 doi: 10.1111/ctr.12223. [Epub ahead of print] PMID: 24033455
Kotulska K, Chmielewski D, Borkowska J, Jurkiewicz E, Kuczyński D, Kmieć T, Łojszczyk B, Dunin-Wąsowicz D, Jóźwiak S
Eur J Paediatr Neurol 2013 Sep;17(5):479-85. Epub 2013 Apr 6 doi: 10.1016/j.ejpn.2013.03.002. [Epub ahead of print] PMID: 23567018

Clinical prediction guides

Piguet AC, Majumder S, Maheshwari U, Manjunathan R, Saran U, Chatterjee S, Dufour JF
Clin Sci (Lond) 2014 Jun;126(11):775-84. doi: 10.1042/CS20130081. PMID: 24283268
Liu Y, Zhang X, Liu J, Hou G, Zhang S, Zhang J
Tumour Biol 2014 Feb;35(2):1275-86. Epub 2013 Sep 8 doi: 10.1007/s13277-013-1170-8. [Epub ahead of print] PMID: 24014089
Cooper M, Wiseman AC, Zibari G, McCague K, Kim Y, Geissler F, Nashan B
Clin Transplant 2013 Nov-Dec;27(6):E625-35. Epub 2013 Sep 6 doi: 10.1111/ctr.12223. [Epub ahead of print] PMID: 24033455
Rosing K, Fobker M, Kannenberg F, Gunia S, Dell'Aquila AM, Kwiecien R, Stypmann J, Nofer JR
Atherosclerosis 2013 Sep;230(1):164-70. Epub 2013 Jul 22 doi: 10.1016/j.atherosclerosis.2013.07.007. [Epub ahead of print] PMID: 23958269
Wiegand G, May TW, Ostertag P, Boor R, Stephani U, Franz DN
Eur J Paediatr Neurol 2013 Nov;17(6):631-8. Epub 2013 Jul 8 doi: 10.1016/j.ejpn.2013.06.002. [Epub ahead of print] PMID: 23845174

Recent systematic reviews

Ravaud A, Urva SR, Grosch K, Cheung WK, Anak O, Sellami DB
Eur J Cancer 2014 Feb;50(3):486-95. Epub 2013 Dec 9 doi: 10.1016/j.ejca.2013.11.022. [Epub ahead of print] PMID: 24332451
Cooper M, Wiseman AC, Zibari G, McCague K, Kim Y, Geissler F, Nashan B
Clin Transplant 2013 Nov-Dec;27(6):E625-35. Epub 2013 Sep 6 doi: 10.1111/ctr.12223. [Epub ahead of print] PMID: 24033455
Mohammadieh AM, Bowler SD, Silverstone EJ, Glanville AR, Yates DH
Med J Aust 2013 Jul 22;199(2):121-3. PMID: 23879512
Funakoshi T, Latif A, Galsky MD
Crit Rev Oncol Hematol 2013 Oct;88(1):30-41. Epub 2013 Jul 5 doi: 10.1016/j.critrevonc.2013.06.001. [Epub ahead of print] PMID: 23830806
Zuckermann A, Wang SS, Epailly E, Barten MJ, Sigurdardottir V, Segovia J, Varnous S, Turazza FM, Potena L, Lehmkuhl HB
Transplant Rev (Orlando) 2013 Jul;27(3):76-84. Epub 2013 May 3 doi: 10.1016/j.trre.2013.03.002. [Epub ahead of print] PMID: 23643624

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