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Dengue

MedGen UID:
3721
Concept ID:
C0011311
Disease or Syndrome
Synonyms: Break Bone Fever; Break-Bone Fever; Breakbone Fever; Classical Dengue; Classical Dengue Fever; Classical Dengue Fevers; Classical Dengues; Dengue Fever; Dengue Fever, Classical; Dengue Fevers, Classical; Dengue, Classical; Dengues, Classical; Fever, Break-Bone; Fever, Breakbone; Fever, Dengue
SNOMED CT: Dengue (38362002); Dengue fever (38362002); Breakbone fever (38362002)
 
Orphanet: ORPHA99828

Definition

Dengue is an infection caused by a virus. You can get it if an infected mosquito bites you. Dengue does not spread from person to person. It is common in warm, wet areas of the world. Outbreaks occur in the rainy season. Dengue is rare in the United States. . Symptoms include a high fever, headaches, joint and muscle pain, vomiting, and a rash. In some cases, dengue turns into dengue hemorrhagic fever, which causes bleeding from your nose, gums, or under your skin. It can also become dengue shock syndrome, which causes massive bleeding and shock. These forms of dengue are life-threatening. There is no specific treatment. Most people with dengue recover within 2 weeks. Until then, drinking lots of fluids, resting and taking non-aspirin fever-reducing medicines might help. People with the more severe forms of dengue usually need to go to the hospital and get fluids. To lower your risk when traveling in dengue-prone countries . - Wear insect repellent with DEET . - Wear clothes that cover your arms, legs and feet . - Close unscreened doors and windows . NIH: National Institute of Allergy and Infectious Diseases.  [from MedlinePlus]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDengue
Follow this link to review classifications for Dengue in Orphanet.

Recent clinical studies

Etiology

L'Azou M, Moureau A, Sarti E, Nealon J, Zambrano B, Wartel TA, Villar L, Capeding MR, Ochiai RL; CYD14 Primary Study Group; CYD15 Primary Study Group
N Engl J Med 2016 Mar 24;374(12):1155-66. doi: 10.1056/NEJMoa1503877. PMID: 27007959
Alera MT, Srikiatkhachorn A, Velasco JM, Tac-An IA, Lago CB, Clapham HE, Fernandez S, Levy JW, Thaisomboonsuk B, Klungthong C, Macareo LR, Nisalak A, Hermann L, Villa D, Yoon IK
PLoS Negl Trop Dis 2016 Feb;10(2):e0004337. Epub 2016 Feb 4 doi: 10.1371/journal.pntd.0004337. PMID: 26845762Free PMC Article
Katzelnick LC, Montoya M, Gresh L, Balmaseda A, Harris E
Proc Natl Acad Sci U S A 2016 Jan 19;113(3):728-33. Epub 2016 Jan 4 doi: 10.1073/pnas.1522136113. [Epub ahead of print] PMID: 26729879Free PMC Article
Toledo J, George L, Martinez E, Lazaro A, Han WW, Coelho GE, Runge Ranzinger S, Horstick O
PLoS Negl Trop Dis 2016 Jan;10(1):e0004284. Epub 2016 Jan 4 doi: 10.1371/journal.pntd.0004284. PMID: 26727113Free PMC Article
Matos D, Tomashek KM, Perez-Padilla J, Muñoz-Jordán J, Hunsperger E, Horiuchi K, Noyd D, Winton C, Foster G, Lanteri M, Linnen JM, Stramer SL
Transfusion 2016 Jan;56(1):215-22. Epub 2015 Sep 7 doi: 10.1111/trf.13288. [Epub ahead of print] PMID: 26469514

Diagnosis

L'Azou M, Moureau A, Sarti E, Nealon J, Zambrano B, Wartel TA, Villar L, Capeding MR, Ochiai RL; CYD14 Primary Study Group; CYD15 Primary Study Group
N Engl J Med 2016 Mar 24;374(12):1155-66. doi: 10.1056/NEJMoa1503877. PMID: 27007959
Cavalcanti LP, Braga DN, da Silva LM, Aguiar MG, Castiglioni M, Silva-Junior JU, Araújo FM, Pereira RA, Malta DL, Pompeu MM
Am J Trop Med Hyg 2016 Jan;94(1):187-92. Epub 2015 Nov 23 doi: 10.4269/ajtmh.15-0392. [Epub ahead of print] PMID: 26598561Free PMC Article
Matos D, Tomashek KM, Perez-Padilla J, Muñoz-Jordán J, Hunsperger E, Horiuchi K, Noyd D, Winton C, Foster G, Lanteri M, Linnen JM, Stramer SL
Transfusion 2016 Jan;56(1):215-22. Epub 2015 Sep 7 doi: 10.1111/trf.13288. [Epub ahead of print] PMID: 26469514
Alagarasu K, Walimbe AM, Jadhav SM, Deoshatwar AR
Epidemiol Infect 2016 Mar;144(4):876-86. Epub 2015 Aug 20 doi: 10.1017/S0950268815001922. [Epub ahead of print] PMID: 26289218
Gelanew T, Poole-Smith BK, Hunsperger E
J Virol Methods 2015 Sep 15;222:214-23. Epub 2015 Jun 9 doi: 10.1016/j.jviromet.2015.06.003. [Epub ahead of print] PMID: 26070890

Therapy

L'Azou M, Moureau A, Sarti E, Nealon J, Zambrano B, Wartel TA, Villar L, Capeding MR, Ochiai RL; CYD14 Primary Study Group; CYD15 Primary Study Group
N Engl J Med 2016 Mar 24;374(12):1155-66. doi: 10.1056/NEJMoa1503877. PMID: 27007959
Matos D, Tomashek KM, Perez-Padilla J, Muñoz-Jordán J, Hunsperger E, Horiuchi K, Noyd D, Winton C, Foster G, Lanteri M, Linnen JM, Stramer SL
Transfusion 2016 Jan;56(1):215-22. Epub 2015 Sep 7 doi: 10.1111/trf.13288. [Epub ahead of print] PMID: 26469514
Screaton G, Mongkolsapaya J, Yacoub S, Roberts C
Nat Rev Immunol 2015 Dec;15(12):745-59. doi: 10.1038/nri3916. PMID: 26603900
Hernández-Fonseca JP, Durán A, Valero N, Mosquera J
Arch Virol 2015 Nov;160(11):2861-5. Epub 2015 Sep 1 doi: 10.1007/s00705-015-2581-1. [Epub ahead of print] PMID: 26321474
Suzarte E, Gil L, Valdés I, Marcos E, Lazo L, Izquierdo A, García A, López L, Álvarez M, Pérez Y, Castro J, Romero Y, Guzmán MG, Guillén G, Hermida L
Int Immunol 2015 Aug;27(8):367-79. Epub 2015 Mar 20 doi: 10.1093/intimm/dxv011. [Epub ahead of print] PMID: 25795768

Prognosis

L'Azou M, Moureau A, Sarti E, Nealon J, Zambrano B, Wartel TA, Villar L, Capeding MR, Ochiai RL; CYD14 Primary Study Group; CYD15 Primary Study Group
N Engl J Med 2016 Mar 24;374(12):1155-66. doi: 10.1056/NEJMoa1503877. PMID: 27007959
Alera MT, Srikiatkhachorn A, Velasco JM, Tac-An IA, Lago CB, Clapham HE, Fernandez S, Levy JW, Thaisomboonsuk B, Klungthong C, Macareo LR, Nisalak A, Hermann L, Villa D, Yoon IK
PLoS Negl Trop Dis 2016 Feb;10(2):e0004337. Epub 2016 Feb 4 doi: 10.1371/journal.pntd.0004337. PMID: 26845762Free PMC Article
Matos D, Tomashek KM, Perez-Padilla J, Muñoz-Jordán J, Hunsperger E, Horiuchi K, Noyd D, Winton C, Foster G, Lanteri M, Linnen JM, Stramer SL
Transfusion 2016 Jan;56(1):215-22. Epub 2015 Sep 7 doi: 10.1111/trf.13288. [Epub ahead of print] PMID: 26469514
Townsley E, O'Connor G, Cosgrove C, Woda M, Co M, Thomas SJ, Kalayanarooj S, Yoon IK, Nisalak A, Srikiatkhachorn A, Green S, Stephens HA, Gostick E, Price DA, Carrington M, Alter G, McVicar DW, Rothman AL, Mathew A
Clin Exp Immunol 2016 Mar;183(3):419-30. Epub 2015 Nov 24 doi: 10.1111/cei.12722. [Epub ahead of print] PMID: 26439909Free PMC Article
van Panhuis WG, Choisy M, Xiong X, Chok NS, Akarasewi P, Iamsirithaworn S, Lam SK, Chong CK, Lam FC, Phommasak B, Vongphrachanh P, Bouaphanh K, Rekol H, Hien NT, Thai PQ, Duong TN, Chuang JH, Liu YL, Ng LC, Shi Y, Tayag EA, Roque VG Jr, Lee Suy LL, Jarman RG, Gibbons RV, Velasco JM, Yoon IK, Burke DS, Cummings DA
Proc Natl Acad Sci U S A 2015 Oct 20;112(42):13069-74. Epub 2015 Oct 5 doi: 10.1073/pnas.1501375112. [Epub ahead of print] PMID: 26438851Free PMC Article

Clinical prediction guides

L'Azou M, Moureau A, Sarti E, Nealon J, Zambrano B, Wartel TA, Villar L, Capeding MR, Ochiai RL; CYD14 Primary Study Group; CYD15 Primary Study Group
N Engl J Med 2016 Mar 24;374(12):1155-66. doi: 10.1056/NEJMoa1503877. PMID: 27007959
Townsley E, O'Connor G, Cosgrove C, Woda M, Co M, Thomas SJ, Kalayanarooj S, Yoon IK, Nisalak A, Srikiatkhachorn A, Green S, Stephens HA, Gostick E, Price DA, Carrington M, Alter G, McVicar DW, Rothman AL, Mathew A
Clin Exp Immunol 2016 Mar;183(3):419-30. Epub 2015 Nov 24 doi: 10.1111/cei.12722. [Epub ahead of print] PMID: 26439909Free PMC Article
Alagarasu K, Walimbe AM, Jadhav SM, Deoshatwar AR
Epidemiol Infect 2016 Mar;144(4):876-86. Epub 2015 Aug 20 doi: 10.1017/S0950268815001922. [Epub ahead of print] PMID: 26289218
van Panhuis WG, Choisy M, Xiong X, Chok NS, Akarasewi P, Iamsirithaworn S, Lam SK, Chong CK, Lam FC, Phommasak B, Vongphrachanh P, Bouaphanh K, Rekol H, Hien NT, Thai PQ, Duong TN, Chuang JH, Liu YL, Ng LC, Shi Y, Tayag EA, Roque VG Jr, Lee Suy LL, Jarman RG, Gibbons RV, Velasco JM, Yoon IK, Burke DS, Cummings DA
Proc Natl Acad Sci U S A 2015 Oct 20;112(42):13069-74. Epub 2015 Oct 5 doi: 10.1073/pnas.1501375112. [Epub ahead of print] PMID: 26438851Free PMC Article
Simon-Loriere E, Lin RJ, Kalayanarooj SM, Chuansumrit A, Casademont I, Lin SY, Yu HP, Lert-Itthiporn W, Chaiyaratana W, Tangthawornchaikul N, Tangnararatchakit K, Vasanawathana S, Chang BL, Suriyaphol P, Yoksan S, Malasit P, Despres P, Paul R, Lin YL, Sakuntabhai A
J Infect Dis 2015 Dec 15;212(12):2011-20. Epub 2015 Jun 10 doi: 10.1093/infdis/jiv321. [Epub ahead of print] PMID: 26063222

Recent systematic reviews

Toledo J, George L, Martinez E, Lazaro A, Han WW, Coelho GE, Runge Ranzinger S, Horstick O
PLoS Negl Trop Dis 2016 Jan;10(1):e0004284. Epub 2016 Jan 4 doi: 10.1371/journal.pntd.0004284. PMID: 26727113Free PMC Article
Alagarasu K, Walimbe AM, Jadhav SM, Deoshatwar AR
Epidemiol Infect 2016 Mar;144(4):876-86. Epub 2015 Aug 20 doi: 10.1017/S0950268815001922. [Epub ahead of print] PMID: 26289218
Carabali M, Hernandez LM, Arauz MJ, Villar LA, Ridde V
BMC Infect Dis 2015 Jul 30;15:301. doi: 10.1186/s12879-015-1058-x. [Epub ahead of print] PMID: 26223700Free PMC Article
Toan NT, Rossi S, Prisco G, Nante N, Viviani S
Trop Med Int Health 2015 Jul;20(7):840-63. Epub 2015 Mar 31 doi: 10.1111/tmi.12498. [Epub ahead of print] PMID: 25753454
Lazaro A, Han WW, Manrique-Saide P, George L, Velayudhan R, Toledo J, Runge Ranzinger S, Horstick O
Trop Med Int Health 2015 Jun;20(6):685-706. Epub 2015 Mar 22 doi: 10.1111/tmi.12485. [Epub ahead of print] PMID: 25708814

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