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Knee dislocation

MedGen UID:
776574
Concept ID:
C2176269
Finding
Synonyms: Dislocations of the knees; Knee dislocations
 
HPO: HP:0004976

Conditions with this feature

Larsen syndrome, dominant type
MedGen UID:
320634
Concept ID:
C1835564
Disease or Syndrome
The FLNB-related disorders include a spectrum of phenotypes ranging from mild (spondylocarpotarsal synostosis [SCT] syndrome and Larsen syndrome) to severe (atelosteogenesis types I [AOI] and III [AOIII], boomerang dysplasia). SCT syndrome is characterized by disproportionate short stature, block vertebrae, scoliosis and lordosis, carpal and tarsal fusion, club feet, hearing loss, dental enamel hypoplasia, and mild facial dysmorphisms. Larsen syndrome is characterized by congenital dislocations of the hip, knee, and elbow; club feet (equinovarus or equinovalgus foot deformities); scoliosis and cervical kyphosis, which can be associated with a cervical myelopathy; short, broad, spatulate distal phalanges; and distinctive craniofacies (prominent forehead, depressed nasal bridge, malar flattening, andwidely spaced eyes). Both can have midline cleft palate and conductive hearing loss. AOIII and AOI are characterized by severe short-limbed dwarfism; dislocated hips, knees, and elbows; and club feet. AOI is lethal in the perinatal period.
Spondyloepiphyseal dysplasia with congenital joint dislocations
MedGen UID:
374477
Concept ID:
C1840471
Disease or Syndrome
CHST3-related skeletal dysplasia is characterized by short stature of prenatal onset, joint dislocations (knees, hips, radial heads), club feet, and limitation of range of motion that can involve all large joints. Kyphosis and occasionally scoliosis with slight shortening of the trunk develop in childhood. Minor heart valve dysplasia has been described in several persons. Intellect, vision, and hearing are normal.
Multiple joint dislocations, short stature, craniofacial dysmorphism, and congenital heart defects
MedGen UID:
383706
Concept ID:
C1855536
Disease or Syndrome
This autosomal recessive phenotype consists of dysmorphic facies, bilateral dislocations of the elbows, hips, and knees, clubfeet, and short stature, as well as cardiovascular defects (summary by Bonaventure et al., 1992). Phenotypic similarities have been noted between this syndrome and Larsen syndrome (150250), an autosomal dominant disorder caused by mutation in the FLNB gene (603381), as well as spondyloepiphyseal dysplasia with congenital joint dislocations (143095), an autosomal recessive disorder caused by mutation in the CHST3 gene (603799) (Bonaventure et al., 1992; Baasanjav et al., 2011).
Atelosteogenesis type 3
MedGen UID:
350666
Concept ID:
C1862414
Gene or Genome
The FLNB-related disorders include a spectrum of phenotypes ranging from mild (spondylocarpotarsal synostosis [SCT] syndrome and Larsen syndrome) to severe (atelosteogenesis types I [AOI] and III [AOIII], boomerang dysplasia). SCT syndrome is characterized by disproportionate short stature, block vertebrae, scoliosis and lordosis, carpal and tarsal fusion, club feet, hearing loss, dental enamel hypoplasia, and mild facial dysmorphisms. Larsen syndrome is characterized by congenital dislocations of the hip, knee, and elbow; club feet (equinovarus or equinovalgus foot deformities); scoliosis and cervical kyphosis, which can be associated with a cervical myelopathy; short, broad, spatulate distal phalanges; and distinctive craniofacies (prominent forehead, depressed nasal bridge, malar flattening, andwidely spaced eyes). Both can have midline cleft palate and conductive hearing loss. AOIII and AOI are characterized by severe short-limbed dwarfism; dislocated hips, knees, and elbows; and club feet. AOI is lethal in the perinatal period.
Camptodactyly 1
MedGen UID:
416550
Concept ID:
C2751430
Disease or Syndrome
Camptodactyly is defined as a permanent flexion contrature of 1 or both fifth fingers at the proximal interphalangeal joints. Additional fingers might be affected, but the little finger is always involved. Usually the condition appears to be sporadic in a family, but clinical examination of relatives reveals that it is an autosomal dominant condition subject to incomplete penetrance and variable expressivity (summary by Malik et al., 2008).
Arthrogryposis, mental retardation, and seizures
MedGen UID:
816240
Concept ID:
C3809910
Disease or Syndrome

Recent clinical studies

Etiology

Whelan DB, Dold AP, Trajkovski T, Chahal J
Clin Orthop Relat Res 2014 Sep;472(9):2698-704. doi: 10.1007/s11999-014-3730-7. PMID: 25002209Free PMC Article
Natsuhara KM, Yeranosian MG, Cohen JR, Wang JC, McAllister DR, Petrigliano FA
Clin Orthop Relat Res 2014 Sep;472(9):2615-20. doi: 10.1007/s11999-014-3566-1. PMID: 24658901Free PMC Article
Krych AJ, Giuseffi SA, Kuzma SA, Stuart MJ, Levy BA
Clin Orthop Relat Res 2014 Sep;472(9):2630-6. doi: 10.1007/s11999-014-3542-9. PMID: 24574124Free PMC Article
Molund M, Engebretsen L, Hvaal K, Hellesnes J, Ellingsen Husebye E
Clin Orthop Relat Res 2014 Sep;472(9):2637-43. doi: 10.1007/s11999-014-3533-x. PMID: 24566891Free PMC Article
Arom GA, Yeranosian MG, Petrigliano FA, Terrell RD, McAllister DR
Clin Orthop Relat Res 2014 Sep;472(9):2609-14. doi: 10.1007/s11999-013-3373-0. PMID: 24214822Free PMC Article

Diagnosis

Whelan DB, Dold AP, Trajkovski T, Chahal J
Clin Orthop Relat Res 2014 Sep;472(9):2698-704. doi: 10.1007/s11999-014-3730-7. PMID: 25002209Free PMC Article
Natsuhara KM, Yeranosian MG, Cohen JR, Wang JC, McAllister DR, Petrigliano FA
Clin Orthop Relat Res 2014 Sep;472(9):2615-20. doi: 10.1007/s11999-014-3566-1. PMID: 24658901Free PMC Article
Medina O, Arom GA, Yeranosian MG, Petrigliano FA, McAllister DR
Clin Orthop Relat Res 2014 Sep;472(9):2621-9. doi: 10.1007/s11999-014-3511-3. PMID: 24554457Free PMC Article
Sillanpää PJ, Kannus P, Niemi ST, Rolf C, Felländer-Tsai L, Mattila VM
J Trauma Acute Care Surg 2014 Mar;76(3):715-9. doi: 10.1097/TA.0000000000000136. PMID: 24553539
Arom GA, Yeranosian MG, Petrigliano FA, Terrell RD, McAllister DR
Clin Orthop Relat Res 2014 Sep;472(9):2609-14. doi: 10.1007/s11999-013-3373-0. PMID: 24214822Free PMC Article

Therapy

Javidan P, Owen J, Cutuk A, Watson T, Kaar S
J Knee Surg 2015 Jun;28(3):247-54. Epub 2014 Jul 28 doi: 10.1055/s-0034-1386579. [Epub ahead of print] PMID: 25068845
Stannard JP, Nuelle CW, McGwin G, Volgas DA
J Bone Joint Surg Am 2014 Feb 5;96(3):184-91. doi: 10.2106/JBJS.L.01603. PMID: 24500579
Jang KM, Lee HS, Wang JH
Knee 2014 Mar;21(2):582-5. Epub 2012 Nov 14 doi: 10.1016/j.knee.2012.09.018. [Epub ahead of print] PMID: 23159148
Capito N, Gregory MH, Volgas D, Sherman SL
J Knee Surg 2013 Dec;26 Suppl 1:S136-41. Epub 2013 Mar 19 doi: 10.1055/s-0033-1341577. [Epub ahead of print] PMID: 23512541
Sato Y, Saito M, Akagi R, Suzuki M, Kobayashi T, Sasho T
Orthopedics 2012 Apr;35(4):e585-8. doi: 10.3928/01477447-20120327-33. PMID: 22495865

Prognosis

Whelan DB, Dold AP, Trajkovski T, Chahal J
Clin Orthop Relat Res 2014 Sep;472(9):2698-704. doi: 10.1007/s11999-014-3730-7. PMID: 25002209Free PMC Article
Natsuhara KM, Yeranosian MG, Cohen JR, Wang JC, McAllister DR, Petrigliano FA
Clin Orthop Relat Res 2014 Sep;472(9):2615-20. doi: 10.1007/s11999-014-3566-1. PMID: 24658901Free PMC Article
Molund M, Engebretsen L, Hvaal K, Hellesnes J, Ellingsen Husebye E
Clin Orthop Relat Res 2014 Sep;472(9):2637-43. doi: 10.1007/s11999-014-3533-x. PMID: 24566891Free PMC Article
Medina O, Arom GA, Yeranosian MG, Petrigliano FA, McAllister DR
Clin Orthop Relat Res 2014 Sep;472(9):2621-9. doi: 10.1007/s11999-014-3511-3. PMID: 24554457Free PMC Article
Arom GA, Yeranosian MG, Petrigliano FA, Terrell RD, McAllister DR
Clin Orthop Relat Res 2014 Sep;472(9):2609-14. doi: 10.1007/s11999-013-3373-0. PMID: 24214822Free PMC Article

Clinical prediction guides

Coraci D, Tsukamoto H, Granata G, Briani C, Santilli V, Padua L
Muscle Nerve 2015 Jun;51(6):859-63. Epub 2015 Apr 24 doi: 10.1002/mus.24472. [Epub ahead of print] PMID: 25288481
Whelan DB, Dold AP, Trajkovski T, Chahal J
Clin Orthop Relat Res 2014 Sep;472(9):2698-704. doi: 10.1007/s11999-014-3730-7. PMID: 25002209Free PMC Article
Krych AJ, Giuseffi SA, Kuzma SA, Stuart MJ, Levy BA
Clin Orthop Relat Res 2014 Sep;472(9):2630-6. doi: 10.1007/s11999-014-3542-9. PMID: 24574124Free PMC Article
Molund M, Engebretsen L, Hvaal K, Hellesnes J, Ellingsen Husebye E
Clin Orthop Relat Res 2014 Sep;472(9):2637-43. doi: 10.1007/s11999-014-3533-x. PMID: 24566891Free PMC Article
Medina O, Arom GA, Yeranosian MG, Petrigliano FA, McAllister DR
Clin Orthop Relat Res 2014 Sep;472(9):2621-9. doi: 10.1007/s11999-014-3511-3. PMID: 24554457Free PMC Article

Recent systematic reviews

Fanelli GC, Sousa PL, Edson CJ
Clin Orthop Relat Res 2014 Sep;472(9):2712-7. doi: 10.1007/s11999-014-3707-6. PMID: 24898528Free PMC Article
Medina O, Arom GA, Yeranosian MG, Petrigliano FA, McAllister DR
Clin Orthop Relat Res 2014 Sep;472(9):2621-9. doi: 10.1007/s11999-014-3511-3. PMID: 24554457Free PMC Article
Vinyard TR, Boyd J, MacDonald PB
J Knee Surg 2012 Sep;25(4):275-86. doi: 10.1055/s-0032-1322598. [Epub ahead of print] PMID: 23150155
Howells NR, Brunton LR, Robinson J, Porteus AJ, Eldridge JD, Murray JR
Injury 2011 Nov;42(11):1198-204. Epub 2010 Dec 14 doi: 10.1016/j.injury.2010.11.018. [Epub ahead of print] PMID: 21156317
Nicandri GT, Dunbar RP, Wahl CJ
Knee Surg Sports Traumatol Arthrosc 2010 Aug;18(8):1005-12. Epub 2009 Sep 25 doi: 10.1007/s00167-009-0918-6. [Epub ahead of print] PMID: 19779891

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