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Results: 15

1.

Signal Transduction Pathways

Describes a group of molecules in a cell that work together to control one or more cell functions, such as cell division or cell death. After the first molecule in a pathway receives a signal, it activates another molecule. This process is repeated until the last molecule is activated and the cell function involved is carried out. Abnormal activation of signaling pathways can lead to cancer, and drugs are being developed to block these pathways. This may help block cancer cell growth and kill cancer cells. [from NCI]

MedGen UID:
39530
Concept ID:
C0086982
Molecular Function
2.

Wnt Signaling Pathway

Wnt family members are secreted glycoproteins that bind to cell surface receptors such as Frizzled. Wnt members can play a role in the expression of many genes by interacting with multiple disparate signaling pathways. (BioCarta) [from NCI]

MedGen UID:
277003
Concept ID:
C1520113
Molecular Function
3.

Murine

MedGen UID:
108834
Concept ID:
C0591833
Pharmacologic Substance
4.

Related

MedGen UID:
619805
Concept ID:
C0445223
Finding
5.

Wnt receptor signaling pathway through beta-catenin

The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes. [GOC:bf, GOC:dph, PMID:11532397] [from GO]

MedGen UID:
453252
Concept ID:
C2262808
Molecular Function
6.

Disease Response

The pathologic and/or clinical changes that result from treatment. The changes may include eradication of detectable disease, stabilization of disease, or disease progression. [from NCI]

MedGen UID:
309976
Concept ID:
C1704632
Finding
7.

Mediator brand of benfluorex hydrochloride

An agent that acts as a link between parties, objects, or actions. [from NCI]

MedGen UID:
93010
Concept ID:
C0127400
Pharmacologic Substance
8.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
9.

Biochemical Processes

Chemical reactions or functions, enzymatic activities, and metabolic pathways of living things. [from MeSH]

MedGen UID:
267723
Concept ID:
C1511130
Molecular Function
10.

Female

A person who belongs to the sex that normally produces ova. The term is used to indicate biological sex distinctions, or cultural gender role distinctions, or both. (NCI) [from NCI_CDISC]

MedGen UID:
8807
Concept ID:
C0015780
Finding
11.

HD 154

MedGen UID:
180123
Concept ID:
C0913930
Pharmacologic Substance
12.

Human adenovirus present

MedGen UID:
749766
Concept ID:
C2585510
Finding
13.

Very small uterus

MedGen UID:
704877
Concept ID:
C1281940
Finding
14.

Wnt Signaling Inhibitor CWP232291

A small molecule and prodrug of CWP232204 targeting Src associated in mitosis, of 68 kDa (Sam68 or KHDRBS1), with potential antineoplastic activity. CWP232291 is converted in serum into its active form CWP232204 which binds to Sam68, thereby resulting in the induction of apoptosis in selective cancer cells. Due to the multimodular structure of Sam68, the apoptosis mediated by CWP232204-Sam68 interaction can attribute from 1) activation of transcription factor NF-kB induced by tumor necrosis factor alpha signaling, 2) alternative splicing of BCL-2 apoptosis gene, driving the balance towards pro-apoptotic as opposed to anti-apoptotic isoforms, 3) down-regulation of the anti-apoptotic protein survivin via Wnt signaling. Sam68, a KH domain RNA-binding protein belonging to the signal transduction and activation of RNA (STAR) family, plays a key role in various cellular processes including cell cycle progression and apoptosis; it is upregulated in many types of cancer cells and its expression is associated with increased cell proliferation and survival. [from NCI]

MedGen UID:
475186
Concept ID:
C3273553
Pharmacologic Substance
15.

Beta-Catenin Accumulation Pathway

Lipopolysaccharide (LPS) from XX bacteria induces a wide range of inflammatory responses, including the response of alveolar macrophages to bacteria in the lungs. CD14 and the Toll-like receptor TLR4 are activated by LPS, initiating a signaling cascade that activates PI3 kinase and increases synthesis of the inositol phosphate PIP3. PIP3 activates the inositol phosphate dependent protein kinase PDK1, which activates AKT (protein kinase B). One of the key actions of AKT is to block apoptosis. AKT phosphorylation of NF-kB promotes the survival and activation of macrophages responding to LPS. Another substrate of AKT is the protein kinase Gsk3-beta. AKT phosphorylates and deactivates Gsk3-beta. Non-phosphorylated Gsk3-beta is active and phosphorylates beta-catenin, leading to its degradation in the ubiquitin dependent proteasome pathway. Stimulation by LPS causes the accumulation of beta-catenin in the nucleus and the activation of genes in concert with the transcription factor LEF1. This pathway is probably not restricted to alveolar pathway, but leads to the activation of beta-catenin dependent genes by LPS in other cells as well. Other pathways regulate this pathway also, such as the modulation of PI3 kinase activity by ceramide and the inhibition of Gsk3-beta activity by the Wnt/frizzled/disheveled (DSH) pathway. [from NCI]

MedGen UID:
267352
Concept ID:
C1511110
Molecular Function

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