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Elevated systolic blood pressure

MedGen UID:
333547
Concept ID:
C1840374
Finding
 
HPO: HP:0004421

Definition

Abnormal increase in systolic blood pressure. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated systolic blood pressure

Conditions with this feature

Essential hypertension
MedGen UID:
88442
Concept ID:
C0085580
Disease or Syndrome
The Pickering school held that blood pressure has a continuous distribution, that multiple genes and multiple environmental factors determine the level of one's blood pressure just as the determination of stature and intelligence is multifactorial, and that 'essential hypertension' is merely the upper end of the distribution (Pickering, 1978). In this view the person with essential hypertension is one who happens to inherit an aggregate of genes determining hypertension (and also is exposed to exogenous factors that favor hypertension). The Platt school took the view that essential hypertension is a simple mendelian dominant trait (Platt, 1963). McDonough et al. (1964) defended the monogenic idea. See McKusick (1960) and Kurtz and Spence (1993) for reviews. Swales (1985) reviewed the Platt-Pickering controversy as an 'episode in recent medical history.' The Pickering point of view appears to be more consistent with the observations.
Nephrogenic syndrome of inappropriate antidiuresis
MedGen UID:
336877
Concept ID:
C1845202
Disease or Syndrome
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common cause of hyponatremia. The syndrome manifests as an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolality, and natriuresis. SIADH occurs in a setting of normal blood volume, without evidence of renal disease or deficiency of thyroxine or cortisol. Although usually transient, SIADH may be chronic; it is often associated with drug use or a lesion in the central nervous system or lung. When the cardinal features of SIADH were defined by Bartter and Schwartz (1967), levels of AVP could not be measured. Subsequently, radioimmunoassays revealed that SIADH is usually associated with measurably elevated serum levels of AVP. Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is characterized by a clinical picture similar to SIADH, but is associated with undetectable levels of AVP (Feldman et al., 2005).

Recent clinical studies

Etiology

Lohr JW, Golzy M, Carter RL, Arora P
J Am Soc Hypertens 2015 Jan;9(1):29-37. Epub 2014 Nov 6 doi: 10.1016/j.jash.2014.10.008. [Epub ahead of print] PMID: 25537459
Laukkanen JA, Willeit P, Kurl S, Mäkikallio TH, Savonen K, Ronkainen K, Rauramaa R
J Hypertens 2014 Mar;32(3):659-66. doi: 10.1097/HJH.0000000000000066. PMID: 24317550
Greaney JL, Matthews EL, Boggs ME, Edwards DG, Duncan RL, Farquhar WB
Am J Physiol Heart Circ Physiol 2014 Jan 1;306(1):H132-41. Epub 2013 Oct 25 doi: 10.1152/ajpheart.00575.2013. [Epub ahead of print] PMID: 24163081
Baker J, Davies B, McCormick MC, Graham M
Res Sports Med 2013;21(1):1-11. doi: 10.1080/15438627.2012.738440. PMID: 23286418
Jablonski KL, Racine ML, Geolfos CJ, Gates PE, Chonchol M, McQueen MB, Seals DR
J Am Coll Cardiol 2013 Jan 22;61(3):335-43. Epub 2012 Nov 7 doi: 10.1016/j.jacc.2012.09.010. [Epub ahead of print] PMID: 23141486Free PMC Article

Diagnosis

Baker J, Davies B, McCormick MC, Graham M
Res Sports Med 2013;21(1):1-11. doi: 10.1080/15438627.2012.738440. PMID: 23286418
Kopciuk KA, Briollais L, Demenais F, Bull SB
BMC Genet 2003 Dec 31;4 Suppl 1:S84. doi: 10.1186/1471-2156-4-S1-S84. PMID: 14975152Free PMC Article
Edick CM, Parnell D, Christensen ML, Hak LJ
J Am Pharm Assoc (Wash) 2000 Sep-Oct;40(5):670-2. PMID: 11029849
Kannel WB
Am J Cardiol 2000 Jan 15;85(2):251-5. PMID: 10955386
Applegate WB, Sowers JR
Am J Med 1996 Sep 30;101(3A):3S-9S. PMID: 8876470

Therapy

Greaney JL, Matthews EL, Boggs ME, Edwards DG, Duncan RL, Farquhar WB
Am J Physiol Heart Circ Physiol 2014 Jan 1;306(1):H132-41. Epub 2013 Oct 25 doi: 10.1152/ajpheart.00575.2013. [Epub ahead of print] PMID: 24163081
Baker J, Davies B, McCormick MC, Graham M
Res Sports Med 2013;21(1):1-11. doi: 10.1080/15438627.2012.738440. PMID: 23286418
Howard G, Lackland DT, Kleindorfer DO, Kissela BM, Moy CS, Judd SE, Safford MM, Cushman M, Glasser SP, Howard VJ
JAMA Intern Med 2013 Jan 14;173(1):46-51. doi: 10.1001/2013.jamainternmed.857. PMID: 23229778Free PMC Article
Jablonski KL, Racine ML, Geolfos CJ, Gates PE, Chonchol M, McQueen MB, Seals DR
J Am Coll Cardiol 2013 Jan 22;61(3):335-43. Epub 2012 Nov 7 doi: 10.1016/j.jacc.2012.09.010. [Epub ahead of print] PMID: 23141486Free PMC Article
Dagle JM, Fisher TJ, Haynes SE, Berends SK, Brophy PD, Morriss FH Jr, Murray JC
J Pediatr 2011 Jul;159(1):104-9. Epub 2011 Feb 24 doi: 10.1016/j.jpeds.2011.01.002. [Epub ahead of print] PMID: 21353244Free PMC Article

Prognosis

Lohr JW, Golzy M, Carter RL, Arora P
J Am Soc Hypertens 2015 Jan;9(1):29-37. Epub 2014 Nov 6 doi: 10.1016/j.jash.2014.10.008. [Epub ahead of print] PMID: 25537459
Laukkanen JA, Willeit P, Kurl S, Mäkikallio TH, Savonen K, Ronkainen K, Rauramaa R
J Hypertens 2014 Mar;32(3):659-66. doi: 10.1097/HJH.0000000000000066. PMID: 24317550
Howard G, Lackland DT, Kleindorfer DO, Kissela BM, Moy CS, Judd SE, Safford MM, Cushman M, Glasser SP, Howard VJ
JAMA Intern Med 2013 Jan 14;173(1):46-51. doi: 10.1001/2013.jamainternmed.857. PMID: 23229778Free PMC Article
Ley EJ, Singer MB, Gangi A, Clond MA, Bukur M, Chung R, Margulies DR, Salim A
J Surg Res 2012 Oct;177(2):326-9. Epub 2012 May 24 doi: 10.1016/j.jss.2012.05.019. [Epub ahead of print] PMID: 22677615
Clond MA, Mirocha J, Singer MB, Bukur M, Salim A, Marguiles DR, Ley EJ
Am J Surg 2011 Dec;202(6):823-7; discussion 828. doi: 10.1016/j.amjsurg.2011.06.044. PMID: 22137141

Clinical prediction guides

Ley EJ, Singer MB, Gangi A, Clond MA, Bukur M, Chung R, Margulies DR, Salim A
J Surg Res 2012 Oct;177(2):326-9. Epub 2012 May 24 doi: 10.1016/j.jss.2012.05.019. [Epub ahead of print] PMID: 22677615
Clond MA, Mirocha J, Singer MB, Bukur M, Salim A, Marguiles DR, Ley EJ
Am J Surg 2011 Dec;202(6):823-7; discussion 828. doi: 10.1016/j.amjsurg.2011.06.044. PMID: 22137141
Duncan AF, Heyne RJ, Morgan JS, Ahmad N, Rosenfeld CR
Pediatr Nephrol 2011 Jul;26(7):1115-21. Epub 2011 Mar 13 doi: 10.1007/s00467-011-1833-x. [Epub ahead of print] PMID: 21399900
Dagle JM, Fisher TJ, Haynes SE, Berends SK, Brophy PD, Morriss FH Jr, Murray JC
J Pediatr 2011 Jul;159(1):104-9. Epub 2011 Feb 24 doi: 10.1016/j.jpeds.2011.01.002. [Epub ahead of print] PMID: 21353244Free PMC Article
He J, Whelton PK
Am Heart J 1999 Sep;138(3 Pt 2):211-9. PMID: 10467215

Recent systematic reviews

Kelishadi R, Mansourian M, Heidari-Beni M
Nutrition 2014 May;30(5):503-10. doi: 10.1016/j.nut.2013.08.014. PMID: 24698343
Kendrick J, Chonchol M
Nat Rev Nephrol 2014 Feb;10(2):71-2. Epub 2013 Dec 10 doi: 10.1038/nrneph.2013.260. [Epub ahead of print] PMID: 24322975
Ley EJ, Singer MB, Gangi A, Clond MA, Bukur M, Chung R, Margulies DR, Salim A
J Surg Res 2012 Oct;177(2):326-9. Epub 2012 May 24 doi: 10.1016/j.jss.2012.05.019. [Epub ahead of print] PMID: 22677615
Gaál EI, Salo P, Kristiansson K, Rehnström K, Kettunen J, Sarin AP, Niemelä M, Jula A, Raitakari OT, Lehtimäki T, Eriksson JG, Widen E, Günel M, Kurki M, von und Zu Fraunberg M, Jääskeläinen JE, Hernesniemi J, Järvelin MR, Pouta A; International Consortium for Blood Pressure Genome-Wide Association Studies, Newton-Cheh C, Salomaa V, Palotie A, Perola M
PLoS Genet 2012;8(3):e1002563. Epub 2012 Mar 15 doi: 10.1371/journal.pgen.1002563. PMID: 22438818Free PMC Article
He J, Whelton PK
J Hypertens Suppl 1999 Jun;17(2):S7-13. PMID: 10465061

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