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Results: 14

1.

Glucose

A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. [from MeSH]

MedGen UID:
42238
Concept ID:
C0017725
Pharmacologic Substance
2.

Arginine

One of the twenty common amino acids (building blocks of proteins). Arginine is being studied as a nutritional supplement in the treatment and prevention of cancer and other conditions. [from NCI]

MedGen UID:
13907
Concept ID:
C0003765
Pharmacologic Substance
3.

Lysine

an essential amino acid [from CHV]

MedGen UID:
7421
Concept ID:
C0024337
Pharmacologic Substance
4.

Absence

MedGen UID:
739164
Concept ID:
C1689985
Anatomical Abnormality
5.

Independent

MedGen UID:
721426
Concept ID:
C1299583
Finding
6.

Able

MedGen UID:
721424
Concept ID:
C1299581
Finding
7.

GTP Binding

GTP Binding is a molecular interaction between specific proteins (containing a GTP binding site) and guanosine 5-prime triphosphate during diverse cellular processes, such as RNA synthesis, translation, signal transduction, and cytoskeletal assembly. [from NCI]

MedGen UID:
216943
Concept ID:
C1149035
Molecular Function
8.

Neu-Laxova syndrome

Neu-Laxova syndrome is an autosomal recessive lethal multiple malformation syndrome characterized by ichthyosis, marked intrauterine growth restriction, microcephaly, short neck, central nervous system anomalies (lissencephaly, cerebellar hypoplasia and/or abnormal/agenesis of the corpus callosum), limb deformities, hypoplastic lungs, edema, and abnormal facial features including severe proptosis with ectropion, hypertelorism, micrognathia, flattened nose, and malformed ears (summary by Manning et al., 2004). [from OMIM]

MedGen UID:
78537
Concept ID:
C0265218
Disease or Syndrome
9.

Biochemical Processes

Chemical reactions or functions, enzymatic activities, and metabolic pathways of living things. [from MeSH]

MedGen UID:
267723
Concept ID:
C1511130
Molecular Function
10.

Protein binding

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments. [from MeSH]

MedGen UID:
18704
Concept ID:
C0033618
Molecular Function
11.

Active Transporter Interaction

Active Transporter Interaction involves temporary non-covalent binding of a molecule through intermolecular physical forces of attraction with a protein that, after conformational change, moves a bound substrate across a cell membrane with (symport) or against (antiport) a concentration gradient resulting directly from the expenditure of energy. [from NCI]

MedGen UID:
760800
Concept ID:
C3537102
Molecular Function
12.

Protein Import into Nucleus Pathway

Nuclear pore complexes (NPCs) are large proteinaceous assemblies that provide the only known portals for exchanging macromolecules between the nucleus and cytoplasm. This includes the movement of small molecules and the selective, facilitated transport of large proteins and RNAs. Faithful, continuous NPC assembly is key for maintaining normal physiological function and is closely tied to proper cell division. One of the unexpected developments during the past decade was the realization that the NPC itself probably does not function primarily as a gating mechanism or by directly transporting cargo macromolecules between the nuclear and cytoplasmic compartments. Instead, nuclear trafficking relies on a range of soluble components. Transport factors bind their cargo in one compartment and then move through the NPCs to the other compartment, where the cargo is released. The transport factor then recycles back through the NPC to participate in another round of transport. In many instances, this process is orchestrated by the Ras-superfamily GTPase Ran. Bischoff et al. describe in detail how the nucleotide state of Ran is controlled by its nuclear guanine-nucleotide-exchange factor (RCC1) and cytoplasmic GTPase-activating protein (RanGAP). The nucleotide state of Ran is crucial to defining the interactions between transport factors, their cargoes and nucleoporins, and is fundamental to the sorting mechanism that defines the directionality of transport. (BioCarta) [from NCI]

MedGen UID:
308071
Concept ID:
C1514547
Molecular Function
13.

Amino-Arginine

An amino acid derivative. As an analog of arginine, amino-arginine competes with the normal substrate arginine and binds to the heme of the NOS as a false substrate, thereby inhibiting endothelial and inducible nitric oxide synthases (eNOS / NOS III and iNOS / NOS II). Arginine is the only physiological substrate for NOS which, in eukaryotic cells, generates NO and L-citrulline from L-arginine and molecular oxygen in a five-electron transfer reaction. This clinical use of amino-arginine is limited due to its epileptogenic properties. (NCI04) [from NCI]

MedGen UID:
307200
Concept ID:
C1510863
Pharmacologic Substance
14.

Active Transporter Interactions [MoA]

MedGen UID:
235111
Concept ID:
C1373104
Molecular Function

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