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Tuberculosis

MedGen UID:
22513
Concept ID:
C0041296
Disease or Syndrome
Synonyms: Disease, Koch's; Disease, Kochs; Koch Disease; Koch's Disease; Kochs Disease; Tuberculoses
SNOMED CT: Tuberculous (371569005); Infection due to Mycobacterium tuberculosis (373576009); TB - Tuberculosis (56717001); Tuberculosis (56717001)
 
Orphanet: ORPHA3389

Definition

Tuberculosis (TB) is a disease caused by bacteria called Mycobacterium tuberculosis. The bacteria usually attack the lungs, but they can also damage other parts of the body. . TB spreads through the air when a person with TB of the lungs or throat coughs, sneezes, or talks. If you have been exposed, you should go to your doctor for tests. You are more likely to get TB if you have a weak immune system. Symptoms of TB in the lungs may include. - A bad cough that lasts 3 weeks or longer. - Weight loss. - Loss of appetite. - Coughing up blood or mucus. - Weakness or fatigue . - Fever. - Night sweats. Skin tests, blood tests, x-rays, and other tests can tell if you have TB. If not treated properly, TB can be deadly. You can usually cure active TB by taking several medicines for a long period of time. NIH: National Institute of Allergy and Infectious Diseases.  [from MedlinePlus]

Recent clinical studies

Etiology

Hosseinipour MC, Bisson GP, Miyahara S, Sun X, Moses A, Riviere C, Kirui FK, Badal-Faesen S, Lagat D, Nyirenda M, Naidoo K, Hakim J, Mugyenyi P, Henostroza G, Leger PD, Lama JR, Mohapi L, Alave J, Mave V, Veloso VG, Pillay S, Kumarasamy N, Bao J, Hogg E, Jones L, Zolopa A, Kumwenda J, Gupta A; Adult AIDS Clinical Trials Group A5274 (REMEMBER) Study Team
Lancet 2016 Mar 19;387(10024):1198-209. doi: 10.1016/S0140-6736(16)00546-8. PMID: 27025337
Peter JG, Zijenah LS, Chanda D, Clowes P, Lesosky M, Gina P, Mehta N, Calligaro G, Lombard CJ, Kadzirange G, Bandason T, Chansa A, Liusha N, Mangu C, Mtafya B, Msila H, Rachow A, Hoelscher M, Mwaba P, Theron G, Dheda K
Lancet 2016 Mar 19;387(10024):1187-97. Epub 2016 Mar 10 doi: 10.1016/S0140-6736(15)01092-2. [Epub ahead of print] PMID: 26970721
Lai TC, Chiang CY, Wu CF, Yang SL, Liu DP, Chan CC, Lin HH
Occup Environ Med 2016 Jan;73(1):56-61. Epub 2015 Oct 29 doi: 10.1136/oemed-2015-102995. [Epub ahead of print] PMID: 26514394
Ferrarini MA, Spina FG, Weckx LY, Lederman HM, De Moraes-Pinto MI
Epidemiol Infect 2016 Mar;144(4):712-23. Epub 2015 Aug 3 doi: 10.1017/S0950268815001727. [Epub ahead of print] PMID: 26234295
Kerkhoff AD, Meintjes G, Burton R, Vogt M, Wood R, Lawn SD
J Infect Dis 2016 Jan 1;213(1):61-70. Epub 2015 Jul 1 doi: 10.1093/infdis/jiv364. [Epub ahead of print] PMID: 26136467Free PMC Article

Diagnosis

Peter JG, Zijenah LS, Chanda D, Clowes P, Lesosky M, Gina P, Mehta N, Calligaro G, Lombard CJ, Kadzirange G, Bandason T, Chansa A, Liusha N, Mangu C, Mtafya B, Msila H, Rachow A, Hoelscher M, Mwaba P, Theron G, Dheda K
Lancet 2016 Mar 19;387(10024):1187-97. Epub 2016 Mar 10 doi: 10.1016/S0140-6736(15)01092-2. [Epub ahead of print] PMID: 26970721
Dheda K, Barry CE 3rd, Maartens G
Lancet 2016 Mar 19;387(10024):1211-26. Epub 2015 Sep 13 doi: 10.1016/S0140-6736(15)00151-8. [Epub ahead of print] PMID: 26377143
Kerkhoff AD, Meintjes G, Burton R, Vogt M, Wood R, Lawn SD
J Infect Dis 2016 Jan 1;213(1):61-70. Epub 2015 Jul 1 doi: 10.1093/infdis/jiv364. [Epub ahead of print] PMID: 26136467Free PMC Article
Kumar NP, Moideen K, Dhakshinraj SD, Banurekha VV, Nair D, Dolla C, Kumaran P, Babu S
Immunology 2015 Oct;146(2):243-50. Epub 2015 Jul 6 doi: 10.1111/imm.12496. [Epub ahead of print] PMID: 26095067Free PMC Article
Pan SJ, Tapley A, Adamson J, Little T, Urbanowski M, Cohen K, Pym A, Almeida D, Dorasamy A, Layre E, Young DC, Singh R, Patel VB, Wallengren K, Ndung'u T, Wilson D, Moody DB, Bishai W
J Infect Dis 2015 Dec 1;212(11):1827-34. Epub 2015 May 26 doi: 10.1093/infdis/jiv312. [Epub ahead of print] PMID: 26014799Free PMC Article

Therapy

Hosseinipour MC, Bisson GP, Miyahara S, Sun X, Moses A, Riviere C, Kirui FK, Badal-Faesen S, Lagat D, Nyirenda M, Naidoo K, Hakim J, Mugyenyi P, Henostroza G, Leger PD, Lama JR, Mohapi L, Alave J, Mave V, Veloso VG, Pillay S, Kumarasamy N, Bao J, Hogg E, Jones L, Zolopa A, Kumwenda J, Gupta A; Adult AIDS Clinical Trials Group A5274 (REMEMBER) Study Team
Lancet 2016 Mar 19;387(10024):1198-209. doi: 10.1016/S0140-6736(16)00546-8. PMID: 27025337
Peter JG, Zijenah LS, Chanda D, Clowes P, Lesosky M, Gina P, Mehta N, Calligaro G, Lombard CJ, Kadzirange G, Bandason T, Chansa A, Liusha N, Mangu C, Mtafya B, Msila H, Rachow A, Hoelscher M, Mwaba P, Theron G, Dheda K
Lancet 2016 Mar 19;387(10024):1187-97. Epub 2016 Mar 10 doi: 10.1016/S0140-6736(15)01092-2. [Epub ahead of print] PMID: 26970721
Lai TC, Chiang CY, Wu CF, Yang SL, Liu DP, Chan CC, Lin HH
Occup Environ Med 2016 Jan;73(1):56-61. Epub 2015 Oct 29 doi: 10.1136/oemed-2015-102995. [Epub ahead of print] PMID: 26514394
Dheda K, Barry CE 3rd, Maartens G
Lancet 2016 Mar 19;387(10024):1211-26. Epub 2015 Sep 13 doi: 10.1016/S0140-6736(15)00151-8. [Epub ahead of print] PMID: 26377143
Xu Z, Zhou A, Ni J, Zhang Q, Wang Y, Lu J, Wu W, Karakousis PC, Lu S, Yao Y
Tuberculosis (Edinb) 2015 Jul;95(4):395-403. Epub 2015 Mar 6 doi: 10.1016/j.tube.2015.02.043. [Epub ahead of print] PMID: 25936536

Prognosis

Lai TC, Chiang CY, Wu CF, Yang SL, Liu DP, Chan CC, Lin HH
Occup Environ Med 2016 Jan;73(1):56-61. Epub 2015 Oct 29 doi: 10.1136/oemed-2015-102995. [Epub ahead of print] PMID: 26514394
Dheda K, Barry CE 3rd, Maartens G
Lancet 2016 Mar 19;387(10024):1211-26. Epub 2015 Sep 13 doi: 10.1016/S0140-6736(15)00151-8. [Epub ahead of print] PMID: 26377143
Ferrarini MA, Spina FG, Weckx LY, Lederman HM, De Moraes-Pinto MI
Epidemiol Infect 2016 Mar;144(4):712-23. Epub 2015 Aug 3 doi: 10.1017/S0950268815001727. [Epub ahead of print] PMID: 26234295
Kerkhoff AD, Meintjes G, Burton R, Vogt M, Wood R, Lawn SD
J Infect Dis 2016 Jan 1;213(1):61-70. Epub 2015 Jul 1 doi: 10.1093/infdis/jiv364. [Epub ahead of print] PMID: 26136467Free PMC Article
Leung CC, Chan CK, Chang KC, Law WS, Lee SN, Tai LB, Leung EC, Tam CM
Hong Kong Med J 2015 Aug;21(4):318-26. Epub 2015 Jul 17 doi: 10.12809/hkmj144492. [Epub ahead of print] PMID: 26183454

Clinical prediction guides

Hosseinipour MC, Bisson GP, Miyahara S, Sun X, Moses A, Riviere C, Kirui FK, Badal-Faesen S, Lagat D, Nyirenda M, Naidoo K, Hakim J, Mugyenyi P, Henostroza G, Leger PD, Lama JR, Mohapi L, Alave J, Mave V, Veloso VG, Pillay S, Kumarasamy N, Bao J, Hogg E, Jones L, Zolopa A, Kumwenda J, Gupta A; Adult AIDS Clinical Trials Group A5274 (REMEMBER) Study Team
Lancet 2016 Mar 19;387(10024):1198-209. doi: 10.1016/S0140-6736(16)00546-8. PMID: 27025337
Wang Y, Yang Y, Li H, Liang Y, Liu J, Yu T, Wu X
Clin Lab 2016;62(1-2):165-72. PMID: 27012046
Kerkhoff AD, Meintjes G, Burton R, Vogt M, Wood R, Lawn SD
J Infect Dis 2016 Jan 1;213(1):61-70. Epub 2015 Jul 1 doi: 10.1093/infdis/jiv364. [Epub ahead of print] PMID: 26136467Free PMC Article
Leung CC, Chan CK, Chang KC, Law WS, Lee SN, Tai LB, Leung EC, Tam CM
Hong Kong Med J 2015 Aug;21(4):318-26. Epub 2015 Jul 17 doi: 10.12809/hkmj144492. [Epub ahead of print] PMID: 26183454
Pang Y, Zhou Y, Wang S, Song Y, Ou X, Zhao B, Zhang Z, Zhao Y
J Infect 2015 Aug;71(2):231-7. Epub 2015 Apr 29 doi: 10.1016/j.jinf.2015.03.012. [Epub ahead of print] PMID: 25936744

Recent systematic reviews

Head MG, Fitchett JR, Derrick G, Wurie FB, Meldrum J, Kumari N, Beattie B, Counts CJ, Atun R
Health Res Policy Syst 2015 Nov 4;13:63. doi: 10.1186/s12961-015-0052-5. [Epub ahead of print] PMID: 26537547Free PMC Article
Gumbo T, Pasipanodya JG, Romero K, Hanna D, Nuermberger E
Clin Infect Dis 2015 Aug 15;61 Suppl 1:S25-31. doi: 10.1093/cid/civ427. PMID: 26224769
Pasipanodya JG, Nuermberger E, Romero K, Hanna D, Gumbo T
Clin Infect Dis 2015 Aug 15;61 Suppl 1:S10-7. doi: 10.1093/cid/civ425. PMID: 26224767
Mao X, Ke Z, Liu S, Tang B, Wang J, Huang H, Chen S
Gene 2015 Nov 15;573(1):75-83. Epub 2015 Jul 11 doi: 10.1016/j.gene.2015.07.025. [Epub ahead of print] PMID: 26169021
Diel R, Lampenius N, Nienhaus A
Pharmacoeconomics 2015 Aug;33(8):783-809. doi: 10.1007/s40273-015-0267-x. PMID: 25774015

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