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Hypersexuality

MedGen UID:
830585
Concept ID:
CN224611
Finding
 
HPO: HP:0030214

Definition

Pathological persistent sexual disinhibiting behavior, directed at oneself or to others. [from HPO]

Conditions with this feature

Hypertryptophanemia, familial
MedGen UID:
322223
Concept ID:
C1833562
Disease or Syndrome
Frontotemporal dementia, ubiquitin-positive
MedGen UID:
375285
Concept ID:
C1843792
Disease or Syndrome
The spectrum of frontotemporal dementia associated with GRN (also known as PGRN) mutations (FTD-GRN or FTD-PGRN) includes the behavioral variant (FTD-bv), primary progressive aphasia (PPA; further sub-categorized as progressive non-fluent aphasia [PNFA] and semantic dementia [SD]), and movement disorders with extrapyramidal features such as parkinsonism and corticobasal syndrome. A broad range of clinical features both within and across families is observed. The age of onset ranges from 35 to 87 years. Behavioral disturbances are the most common early feature, followed by progressive aphasia. Impairment in executive function manifests as loss of judgment and insight. In early stages, PPA often manifests as deficits in naming, word finding, or word comprehension. In late stages, affected individuals often become mute and lose their ability to communicate. Early findings of parkinsonism include rigidity, bradykinesia or akinesia (slowing or absence of movements), limb dystonia, apraxia (loss of ability to carry out learned purposeful movements), and disequilibrium. Late motor findings may include myoclonus, dysarthria, and dysphagia. Most affected individuals eventually lose the ability to walk. Disease duration is three to 12 years.

Recent clinical studies

Etiology

Klein V, Rettenberger M, Briken P
J Sex Med 2014 Aug;11(8):1974-81. Epub 2014 Jun 9 doi: 10.1111/jsm.12602. [Epub ahead of print] PMID: 24909396
Pachankis JE, Rendina HJ, Ventuneac A, Grov C, Parsons JT
Arch Sex Behav 2014 May;43(4):669-83. Epub 2014 Feb 21 doi: 10.1007/s10508-014-0261-y. [Epub ahead of print] PMID: 24558123Free PMC Article
Politis M, Loane C, Wu K, O'Sullivan SS, Woodhead Z, Kiferle L, Lawrence AD, Lees AJ, Piccini P
Brain 2013 Feb;136(Pt 2):400-11. Epub 2013 Jan 31 doi: 10.1093/brain/aws326. [Epub ahead of print] PMID: 23378222
Cross BS, DeYoung GR, Furmaga KM
Ann Pharmacother 2013 Jan;47(1):e1. Epub 2013 Jan 16 doi: 10.1345/aph.1R533. [Epub ahead of print] PMID: 23324505
Vitale C, Santangelo G, Trojano L, Verde F, Rocco M, Grossi D, Barone P
Mov Disord 2011 Apr;26(5):830-6. Epub 2011 Mar 2 doi: 10.1002/mds.23567. [Epub ahead of print] PMID: 21370268

Diagnosis

Calabrò RS, Cordici F, Genovese C, Bramanti P
Arch Sex Behav 2014 Jan;43(1):187-9. Epub 2013 Jun 4 doi: 10.1007/s10508-013-0137-6. [Epub ahead of print] PMID: 23733158
Cantor JM, Klein C, Lykins A, Rullo JE, Thaler L, Walling BR
Arch Sex Behav 2013 Jul;42(5):883-93. Epub 2013 Mar 2 doi: 10.1007/s10508-013-0085-1. [Epub ahead of print] PMID: 23455658Free PMC Article
Pereira B, Llorca PM, Durif F, Brousse G, Blanc O, Rieu I, Derost P, Ulla M, Debilly B, de Chazeron I
Parkinsonism Relat Disord 2013 Feb;19(2):242-6. Epub 2012 Nov 21 doi: 10.1016/j.parkreldis.2012.10.017. [Epub ahead of print] PMID: 23176749
Adelson S, Bell R, Graff A, Goldenberg D, Haase E, Downey JI, Friedman RC
Psychodyn Psychiatry 2012 Sep;40(3):481-503. doi: 10.1521/pdps.2012.40.3.481. PMID: 23002706
Walters GD, Knight RA, Långström N
Arch Sex Behav 2011 Dec;40(6):1309-21. Epub 2011 Feb 3 doi: 10.1007/s10508-010-9719-8. [Epub ahead of print] PMID: 21290258

Therapy

Reyes D, Kurako K, Galvez-Jimenez N
J Clin Neurosci 2014 Mar;21(3):507-8. Epub 2013 Sep 20 doi: 10.1016/j.jocn.2013.04.021. [Epub ahead of print] PMID: 24055209
Calabrò RS, Cordici F, Genovese C, Bramanti P
Arch Sex Behav 2014 Jan;43(1):187-9. Epub 2013 Jun 4 doi: 10.1007/s10508-013-0137-6. [Epub ahead of print] PMID: 23733158
Politis M, Loane C, Wu K, O'Sullivan SS, Woodhead Z, Kiferle L, Lawrence AD, Lees AJ, Piccini P
Brain 2013 Feb;136(Pt 2):400-11. Epub 2013 Jan 31 doi: 10.1093/brain/aws326. [Epub ahead of print] PMID: 23378222
Cross BS, DeYoung GR, Furmaga KM
Ann Pharmacother 2013 Jan;47(1):e1. Epub 2013 Jan 16 doi: 10.1345/aph.1R533. [Epub ahead of print] PMID: 23324505
Canevelli M, Talarico G, Tosto G, Troili F, Lenzi GL, Bruno G
Alzheimer Dis Assoc Disord 2013 Jul-Sep;27(3):287-8. doi: 10.1097/WAD.0b013e31825c85ae. PMID: 22683665

Prognosis

Pachankis JE, Rendina HJ, Ventuneac A, Grov C, Parsons JT
Arch Sex Behav 2014 May;43(4):669-83. Epub 2014 Feb 21 doi: 10.1007/s10508-014-0261-y. [Epub ahead of print] PMID: 24558123Free PMC Article
Senthilkumaran S, Balamurgan N, Sweni S, Menezes RG, Thirumalaikolundusubramanian P
Arch Sex Behav 2011 Dec;40(6):1327-8. Epub 2011 Jun 9 doi: 10.1007/s10508-011-9788-3. [Epub ahead of print] PMID: 21656332
Reid RC, Stein JA, Carpenter BN
J Nerv Ment Dis 2011 Apr;199(4):263-7. doi: 10.1097/NMD.0b013e3182125b96. PMID: 21451351
Walters GD, Knight RA, Långström N
Arch Sex Behav 2011 Dec;40(6):1309-21. Epub 2011 Feb 3 doi: 10.1007/s10508-010-9719-8. [Epub ahead of print] PMID: 21290258
Martín Fernández F, Martín González T
Actas Esp Psiquiatr 2009 Mar-Apr;37(2):118-22. PMID: 19401861

Clinical prediction guides

Klein V, Rettenberger M, Briken P
J Sex Med 2014 Aug;11(8):1974-81. Epub 2014 Jun 9 doi: 10.1111/jsm.12602. [Epub ahead of print] PMID: 24909396
Pachankis JE, Rendina HJ, Ventuneac A, Grov C, Parsons JT
Arch Sex Behav 2014 May;43(4):669-83. Epub 2014 Feb 21 doi: 10.1007/s10508-014-0261-y. [Epub ahead of print] PMID: 24558123Free PMC Article
Politis M, Loane C, Wu K, O'Sullivan SS, Woodhead Z, Kiferle L, Lawrence AD, Lees AJ, Piccini P
Brain 2013 Feb;136(Pt 2):400-11. Epub 2013 Jan 31 doi: 10.1093/brain/aws326. [Epub ahead of print] PMID: 23378222
Pereira B, Llorca PM, Durif F, Brousse G, Blanc O, Rieu I, Derost P, Ulla M, Debilly B, de Chazeron I
Parkinsonism Relat Disord 2013 Feb;19(2):242-6. Epub 2012 Nov 21 doi: 10.1016/j.parkreldis.2012.10.017. [Epub ahead of print] PMID: 23176749
Müller JL
J Sex Med 2011 Nov;8(11):3241-9. Epub 2009 Sep 14 doi: 10.1111/j.1743-6109.2009.01485.x. [Epub ahead of print] PMID: 19751388

Recent systematic reviews

Oliveira MM, Conti C, Prado GF
Cochrane Database Syst Rev 2013 Aug 14;8:CD006685. doi: 10.1002/14651858.CD006685.pub3. PMID: 23945927
Mendez M, Shapira JS
J Sex Med 2011 Apr;8(4):1092-100. Epub 2011 Jan 14 doi: 10.1111/j.1743-6109.2010.02172.x. [Epub ahead of print] PMID: 21235721
Bolea-Alamanac BM, Davies SJ, Christmas DM, Baxter H, Cullum S, Nutt DJ
J Psychopharmacol 2011 Jan;25(1):141-5. Epub 2009 Nov 26 doi: 10.1177/0269881109353460. [Epub ahead of print] PMID: 19942637
Klos KJ, Bower JH, Josephs KA, Matsumoto JY, Ahlskog JE
Parkinsonism Relat Disord 2005 Sep;11(6):381-6. doi: 10.1016/j.parkreldis.2005.06.005. PMID: 16109498
Levitsky AM, Owens NJ
J Am Geriatr Soc 1999 Feb;47(2):231-4. PMID: 9988296

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