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Pain

MedGen UID:
776584
Concept ID:
C2364139
Finding
 
HPO: HP:0012531

Term Hierarchy

Conditions with this feature

Primary erythromelalgia
MedGen UID:
8688
Concept ID:
C0014805
Disease or Syndrome
SCN9A-related inherited erythromelalgia (SCN9A-related IEM) is characterized by recurrent attacks of bilateral and symmetric intense pain, redness, warmth, and swelling involving the feet and, less frequently, the hands. SCN9A-related IEM is not associated with an organic disease. Manifestations may vary within a family. Onset is usually in childhood or adolescence but has been recognized in infants and adults. At onset, episodes are triggered by warmth; other precipitating factors include: exercise, tight shoes, wearing socks, alcohol, spicy foods, and other vasodilating agents. In advanced disease, symptoms may occur many times a day or become constant. Some individuals have allodynia (pain evoked by a normally innocuous stimulus) and hyperalgesia (increased sensitivity to a painful stimulus). Episodes may be disabling, interfere with sleep, and severely limit normal activities such as walking, participation in sports, wearing socks and shoes, and attending school or going to work.
Buerger disease
MedGen UID:
21531
Concept ID:
C0040021
Disease or Syndrome
A non-atherosclerotic, inflammatory thrombotic disease that commonly involves small and medium-sized arteries or veins in the extremities. It is characterized by occlusive THROMBOSIS and FIBROSIS in the vascular wall leading to digital and limb ISCHEMIA and ulcerations. Thromboangiitis obliterans is highly associated with tobacco smoking.
Charcot-Marie-Tooth disease, type 2A2
MedGen UID:
373098
Concept ID:
C1836485
Disease or Syndrome
Charcot-Marie-Tooth hereditary neuropathy type 2A (CMT2A) is a classic axonal peripheral sensorimotor neuropathy characterized by earlier and more severe involvement of the lower extremities than the upper extremities, distal upper-extremity involvement as the neuropathy progresses, more prominent motor deficits than sensory deficits, and normal (>42 m/s) or only slightly decreased nerve conduction velocities (NCVs). Postural tremor is common. Most affected individuals develop symptoms in the first or second decade. It has recently been suggested that CMT2A represents more than 90% of the severe dominant CMT2 cases. However, milder late-onset cases and unusual presentations have also been described.

Recent clinical studies

Etiology

Klit H, Hansen AP, Marcussen NS, Finnerup NB, Jensen TS
Pain 2014 Dec;155(12):2699-706. Epub 2014 Oct 2 doi: 10.1016/j.pain.2014.09.037. [Epub ahead of print] PMID: 25284071
Rakel BA, Zimmerman MB, Geasland K, Embree J, Clark CR, Noiseux NO, Callaghan JJ, Herr K, Walsh D, Sluka KA
Pain 2014 Dec;155(12):2599-611. Epub 2014 Sep 28 doi: 10.1016/j.pain.2014.09.025. [Epub ahead of print] PMID: 25270585Free PMC Article
Ceko M, Milenkovic N, le Coutre P, Westermann J, Lewin GR
Pain 2014 Jul;155(7):1222-8. Epub 2014 Mar 21 doi: 10.1016/j.pain.2014.03.010. [Epub ahead of print] PMID: 24662807
Zheng Z, Wang K, Yao D, Xue CC, Arendt-Nielsen L
Pain 2014 May;155(5):968-76. Epub 2014 Feb 3 doi: 10.1016/j.pain.2014.01.024. [Epub ahead of print] PMID: 24502842
Jahn P, Kuss O, Schmidt H, Bauer A, Kitzmantel M, Jordan K, Krasemann S, Landenberger M
Pain 2014 Apr;155(4):746-54. Epub 2014 Jan 13 doi: 10.1016/j.pain.2014.01.006. [Epub ahead of print] PMID: 24434732

Diagnosis

Klit H, Hansen AP, Marcussen NS, Finnerup NB, Jensen TS
Pain 2014 Dec;155(12):2699-706. Epub 2014 Oct 2 doi: 10.1016/j.pain.2014.09.037. [Epub ahead of print] PMID: 25284071
Ceko M, Milenkovic N, le Coutre P, Westermann J, Lewin GR
Pain 2014 Jul;155(7):1222-8. Epub 2014 Mar 21 doi: 10.1016/j.pain.2014.03.010. [Epub ahead of print] PMID: 24662807
Vervoort T, Logan DE, Goubert L, De Clercq B, Hublet A
Pain 2014 Jun;155(6):1118-27. Epub 2014 Mar 12 doi: 10.1016/j.pain.2014.02.021. [Epub ahead of print] PMID: 24631587
Zheng Z, Wang K, Yao D, Xue CC, Arendt-Nielsen L
Pain 2014 May;155(5):968-76. Epub 2014 Feb 3 doi: 10.1016/j.pain.2014.01.024. [Epub ahead of print] PMID: 24502842
Izumi M, Petersen KK, Arendt-Nielsen L, Graven-Nielsen T
Pain 2014 Apr;155(4):792-800. Epub 2014 Jan 18 doi: 10.1016/j.pain.2014.01.008. [Epub ahead of print] PMID: 24447510

Therapy

Rakel BA, Zimmerman MB, Geasland K, Embree J, Clark CR, Noiseux NO, Callaghan JJ, Herr K, Walsh D, Sluka KA
Pain 2014 Dec;155(12):2599-611. Epub 2014 Sep 28 doi: 10.1016/j.pain.2014.09.025. [Epub ahead of print] PMID: 25270585Free PMC Article
Geuter S, Gamer M, Onat S, Büchel C
Pain 2014 May;155(5):994-1001. Epub 2014 Feb 10 doi: 10.1016/j.pain.2014.02.005. [Epub ahead of print] PMID: 24525275
Zheng Z, Wang K, Yao D, Xue CC, Arendt-Nielsen L
Pain 2014 May;155(5):968-76. Epub 2014 Feb 3 doi: 10.1016/j.pain.2014.01.024. [Epub ahead of print] PMID: 24502842
Izumi M, Petersen KK, Arendt-Nielsen L, Graven-Nielsen T
Pain 2014 Apr;155(4):792-800. Epub 2014 Jan 18 doi: 10.1016/j.pain.2014.01.008. [Epub ahead of print] PMID: 24447510
Jahn P, Kuss O, Schmidt H, Bauer A, Kitzmantel M, Jordan K, Krasemann S, Landenberger M
Pain 2014 Apr;155(4):746-54. Epub 2014 Jan 13 doi: 10.1016/j.pain.2014.01.006. [Epub ahead of print] PMID: 24434732

Prognosis

Klit H, Hansen AP, Marcussen NS, Finnerup NB, Jensen TS
Pain 2014 Dec;155(12):2699-706. Epub 2014 Oct 2 doi: 10.1016/j.pain.2014.09.037. [Epub ahead of print] PMID: 25284071
Geuter S, Gamer M, Onat S, Büchel C
Pain 2014 May;155(5):994-1001. Epub 2014 Feb 10 doi: 10.1016/j.pain.2014.02.005. [Epub ahead of print] PMID: 24525275
Wideman TH, Finan PH, Edwards RR, Quartana PJ, Buenaver LF, Haythornthwaite JA, Smith MT
Pain 2014 Apr;155(4):703-11. Epub 2013 Dec 28 doi: 10.1016/j.pain.2013.12.028. [Epub ahead of print] PMID: 24378879
Khoshnejad M, Fortin MC, Rohani F, Duncan GH, Rainville P
Pain 2014 Mar;155(3):581-90. Epub 2013 Dec 12 doi: 10.1016/j.pain.2013.12.015. [Epub ahead of print] PMID: 24333948
Emerson NM, Zeidan F, Lobanov OV, Hadsel MS, Martucci KT, Quevedo AS, Starr CJ, Nahman-Averbuch H, Weissman-Fogel I, Granovsky Y, Yarnitsky D, Coghill RC
Pain 2014 Mar;155(3):566-73. Epub 2013 Dec 11 doi: 10.1016/j.pain.2013.12.004. [Epub ahead of print] PMID: 24333778Free PMC Article

Clinical prediction guides

Ashton-James CE, Richardson DC, de C Williams AC, Bianchi-Berthouze N, Dekker PH
Pain 2014 Dec;155(12):2656-61. Epub 2014 Oct 13 doi: 10.1016/j.pain.2014.09.031. [Epub ahead of print] PMID: 25307197
Klit H, Hansen AP, Marcussen NS, Finnerup NB, Jensen TS
Pain 2014 Dec;155(12):2699-706. Epub 2014 Oct 2 doi: 10.1016/j.pain.2014.09.037. [Epub ahead of print] PMID: 25284071
Ceko M, Milenkovic N, le Coutre P, Westermann J, Lewin GR
Pain 2014 Jul;155(7):1222-8. Epub 2014 Mar 21 doi: 10.1016/j.pain.2014.03.010. [Epub ahead of print] PMID: 24662807
Geuter S, Gamer M, Onat S, Büchel C
Pain 2014 May;155(5):994-1001. Epub 2014 Feb 10 doi: 10.1016/j.pain.2014.02.005. [Epub ahead of print] PMID: 24525275
Izumi M, Petersen KK, Arendt-Nielsen L, Graven-Nielsen T
Pain 2014 Apr;155(4):792-800. Epub 2014 Jan 18 doi: 10.1016/j.pain.2014.01.008. [Epub ahead of print] PMID: 24447510

Recent systematic reviews

Boerner KE, Birnie KA, Caes L, Schinkel M, Chambers CT
Pain 2014 May;155(5):983-93. Epub 2014 Feb 6 doi: 10.1016/j.pain.2014.01.031. [Epub ahead of print] PMID: 24508752
Stevens BJ, Yamada J, Estabrooks CA, Stinson J, Campbell F, Scott SD, Cummings G; CIHR Team in Children’s Pain
Pain 2014 Jan;155(1):60-8. Epub 2013 Sep 8 doi: 10.1016/j.pain.2013.09.007. [Epub ahead of print] PMID: 24021861
Hirschfeld G, Zernikow B
Pain 2013 Dec;154(12):2626-32. Epub 2013 Jun 3 doi: 10.1016/j.pain.2013.05.048. [Epub ahead of print] PMID: 23742796
Andrew Moore R
Pain 2013 Dec;154 Suppl 1:S77-86. Epub 2013 Mar 15 doi: 10.1016/j.pain.2013.03.024. [Epub ahead of print] PMID: 23622761
Finnerup NB
Pain 2013 Dec;154 Suppl 1:S71-6. Epub 2012 Dec 22 doi: 10.1016/j.pain.2012.12.007. [Epub ahead of print] PMID: 23375163

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