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Results: 8

1.

MedGen UID:
182636
Concept ID:
C0939234
2.

Osteoarthritis susceptibility 1

Osteoarthritis (OA) is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis (Meulenbelt et al., 2006). Clinical problems include pain and joint stiffness often leading to significant disability and joint replacement. Osteoarthritis exhibits a clear predilection for specific joints; it appears most commonly in the hip and knee joints and lumbar and cervical spine, as well as in the distal interphalangeal and the first carpometacarpal (base of thumb) and proximal interphalangeal joints of the hand; however, patients with osteoarthritis may have 1, a few, or all of these sites affected (Stefansson et al., 2003). According to a conservative estimate, greater than 70% of the population of the United States at age 65 years is affected by the disease, reflecting its age dependence. [from OMIM]

MedGen UID:
45244
Concept ID:
C0029408
Disease or Syndrome
3.

Hylan

MedGen UID:
31536
Concept ID:
C0063204
Pharmacologic Substance
4.

Osteoarthritis

MedGen UID:
505348
Concept ID:
CN002503
Finding
5.

Cross-linked hyaluronan

MedGen UID:
732651
Concept ID:
C1445580
Pharmacologic Substance
6.

Severe Adverse Event - CTCAE v4 Grade 3

An adverse event that is medically significant but not life-threatening; or for which inpatient care or prolongation of hospitalization are indicated; or that is an important medical event that does not result in hospitalization, but may jeopardize the patient or may require intervention either to prevent hospitalization, to prevent the AE from becoming life-threatening or causing death; or that is disabling; or that results in persistent or significant disability, incapacity, or limitation of self care activities of daily living (ADLs, e.g., getting in and out of bed, dressing, eating, getting around inside, bathing, or using the toilet). [from NCI]

MedGen UID:
415879
Concept ID:
C2919019
Finding
7.

Grade 3 Severe Adverse Event

A type of adverse event that interrupts usual activities of daily living, or significantly affects clinical status, or may require intensive therapeutic intervention. [from NCI]

MedGen UID:
276803
Concept ID:
C1519275
Finding
8.

Breakthrough Pain

Acute pain that comes on rapidly despite the use of pain medication. [from MeSH]

MedGen UID:
210036
Concept ID:
C1135120
Sign or Symptom

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