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Results: 7

1.

A synthetic, acyclic, monophosphate nucleotide analog of deoxycytidine with antiviral activity, and mostly used against cytomegalovirus (CMV). After incorporation into the host cell, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated into the growing viral DNA strands. As a result, it prevents further DNA polymerization and disrupts DNA replication of viruses. [from NCI]

MedGen UID:
129447
Concept ID:
C0286079
2.

A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. According to the degree of nuclear atypia, number of mitotic figures, and presence of architectural distortion, it is classified as low grade (mild dysplasia) or high grade (moderate or severe dysplasia). [from NCI]

MedGen UID:
164203
Concept ID:
C0878500
3.

Severe

A term used to describe cells that look abnormal under a microscope. These cells are more likely to grow and spread quickly than cells in low-grade cancer or in growths that may become cancer. [from NCI]

MedGen UID:
104640
Concept ID:
C0205082
4.

Vulval intraepithelial neoplasia

A precancerous neoplastic process characterized by dysplasia and maturation abnormalities of the vulvar squamous epithelium. There is no evidence of invasion. It is associated with human papillomavirus infection and is classified as low or high grade. [from NCI]

MedGen UID:
91093
Concept ID:
C0346210
Neoplastic Process
5.

HIV Seropositivity

Development of neutralizing antibodies in individuals who have been exposed to the human immunodeficiency virus (HIV/HTLV-III/LAV). [from MeSH]

MedGen UID:
6860
Concept ID:
C0019699
Finding
6.

Neoplasm of anus

A benign or malignant neoplasm that affects the anal canal or anal margin. Representative examples of benign neoplasms include squamous papilloma and papillary hidradenoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and melanoma. [from NCI]

MedGen UID:
360
Concept ID:
C0003463
Neoplastic Process
7.

Painful sensation in the skin. [from NCI]

MedGen UID:
116116
Concept ID:
C0241136

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