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Tuberculosis

MedGen UID:
22513
Concept ID:
C0041296
Disease or Syndrome
Synonyms: Disease, Koch's; Disease, Kochs; Koch Disease; Koch's Disease; Kochs Disease; Tuberculoses
Modes of inheritance:
not inherited
MedGen UID:
832438
Concept ID:
CN227390
Intellectual Product
Describes a disorder that is not inherited.
SNOMED CT: Tuberculous (371569005); Infection due to Mycobacterium tuberculosis (373576009); TB - Tuberculosis (56717001); Tuberculosis (56717001)
 
Orphanet: ORPHA3389

Definition

Tuberculosis (TB) is a disease caused by bacteria called Mycobacterium tuberculosis. The bacteria usually attack the lungs, but they can also damage other parts of the body. . TB spreads through the air when a person with TB of the lungs or throat coughs, sneezes, or talks. If you have been exposed, you should go to your doctor for tests. You are more likely to get TB if you have a weak immune system. Symptoms of TB in the lungs may include. - A bad cough that lasts 3 weeks or longer. - Weight loss. - Loss of appetite. - Coughing up blood or mucus. - Weakness or fatigue . - Fever. - Night sweats. Skin tests, blood tests, x-rays, and other tests can tell if you have TB. If not treated properly, TB can be deadly. You can usually cure active TB by taking several medicines for a long period of time. NIH: National Institute of Allergy and Infectious Diseases.  [from MedlinePlus]

Recent clinical studies

Etiology

Stucki D, Ballif M, Bodmer T, Coscolla M, Maurer AM, Droz S, Butz C, Borrell S, Längle C, Feldmann J, Furrer H, Mordasini C, Helbling P, Rieder HL, Egger M, Gagneux S, Fenner L
J Infect Dis 2015 Apr 15;211(8):1306-16. Epub 2014 Oct 30 doi: 10.1093/infdis/jiu601. [Epub ahead of print] PMID: 25362193Free PMC Article
Oshi SN, Alobu I, Ukwaja KN, Oshi DC
Epidemiol Infect 2015 Apr;143(5):932-42. Epub 2014 Oct 30 doi: 10.1017/S095026881400291X. [Epub ahead of print] PMID: 25355040
Velayati AA, Farnia P, Mozafari M, Malekshahian D, Farahbod AM, Seif S, Rahideh S, Mirsaeidi M
Chest 2015 Apr;147(4):1094-102. doi: 10.1378/chest.14-0960. PMID: 25340935Free PMC Article
Guerra-Assunção JA, Houben RM, Crampin AC, Mzembe T, Mallard K, Coll F, Khan P, Banda L, Chiwaya A, Pereira RP, McNerney R, Harris D, Parkhill J, Clark TG, Glynn JR
J Infect Dis 2015 Apr 1;211(7):1154-63. Epub 2014 Oct 21 doi: 10.1093/infdis/jiu574. [Epub ahead of print] PMID: 25336729Free PMC Article
Lassausaie J, Bret A, Bouapao X, Chanthavong V, Castonguay-Vanier J, Quet F, Mikota SK, Théorêt C, Buisson Y, Bouchard B
Epidemiol Infect 2015 Apr;143(5):922-31. Epub 2014 Aug 29 doi: 10.1017/S0950268814002180. [Epub ahead of print] PMID: 25170549

Diagnosis

Pantoja A, Kik SV, Denkinger CM
J Infect Dis 2015 Apr 1;211 Suppl 2:S67-77. doi: 10.1093/infdis/jiu820. PMID: 25765108
Kik SV, Denkinger CM, Jefferson C, Ginnard J, Pai M
J Infect Dis 2015 Apr 1;211 Suppl 2:S58-66. doi: 10.1093/infdis/jiu817. PMID: 25765107
Pai M, Schito M
J Infect Dis 2015 Apr 1;211 Suppl 2:S21-8. doi: 10.1093/infdis/jiu803. PMID: 25765103Free PMC Article
Stucki D, Ballif M, Bodmer T, Coscolla M, Maurer AM, Droz S, Butz C, Borrell S, Längle C, Feldmann J, Furrer H, Mordasini C, Helbling P, Rieder HL, Egger M, Gagneux S, Fenner L
J Infect Dis 2015 Apr 15;211(8):1306-16. Epub 2014 Oct 30 doi: 10.1093/infdis/jiu601. [Epub ahead of print] PMID: 25362193Free PMC Article
Guerra-Assunção JA, Houben RM, Crampin AC, Mzembe T, Mallard K, Coll F, Khan P, Banda L, Chiwaya A, Pereira RP, McNerney R, Harris D, Parkhill J, Clark TG, Glynn JR
J Infect Dis 2015 Apr 1;211(7):1154-63. Epub 2014 Oct 21 doi: 10.1093/infdis/jiu574. [Epub ahead of print] PMID: 25336729Free PMC Article

Therapy

Nguyen HT, Hickson RI, Kompas T, Mercer GN, Lokuge KM
Value Health 2015 Mar;18(2):180-8. Epub 2015 Jan 13 doi: 10.1016/j.jval.2014.11.008. [Epub ahead of print] PMID: 25773553
Oshi SN, Alobu I, Ukwaja KN, Oshi DC
Epidemiol Infect 2015 Apr;143(5):932-42. Epub 2014 Oct 30 doi: 10.1017/S095026881400291X. [Epub ahead of print] PMID: 25355040
Guerra-Assunção JA, Houben RM, Crampin AC, Mzembe T, Mallard K, Coll F, Khan P, Banda L, Chiwaya A, Pereira RP, McNerney R, Harris D, Parkhill J, Clark TG, Glynn JR
J Infect Dis 2015 Apr 1;211(7):1154-63. Epub 2014 Oct 21 doi: 10.1093/infdis/jiu574. [Epub ahead of print] PMID: 25336729Free PMC Article
Middelkoop K, Mathema B, Myer L, Shashkina E, Whitelaw A, Kaplan G, Kreiswirth B, Wood R, Bekker LG
J Infect Dis 2015 Jan 1;211(1):53-61. Epub 2014 Jul 22 doi: 10.1093/infdis/jiu403. [Epub ahead of print] PMID: 25053739Free PMC Article
Zumla A, Rao M, Parida SK, Keshavjee S, Cassell G, Wallis R, Axelsson-Robertsson R, Doherty M, Andersson J, Maeurer M
J Intern Med 2015 Apr;277(4):373-87. Epub 2014 May 19 doi: 10.1111/joim.12256. [Epub ahead of print] PMID: 24717092

Prognosis

Nguyen HT, Hickson RI, Kompas T, Mercer GN, Lokuge KM
Value Health 2015 Mar;18(2):180-8. Epub 2015 Jan 13 doi: 10.1016/j.jval.2014.11.008. [Epub ahead of print] PMID: 25773553
Velayati AA, Farnia P, Mozafari M, Malekshahian D, Farahbod AM, Seif S, Rahideh S, Mirsaeidi M
Chest 2015 Apr;147(4):1094-102. doi: 10.1378/chest.14-0960. PMID: 25340935Free PMC Article
Guerra-Assunção JA, Houben RM, Crampin AC, Mzembe T, Mallard K, Coll F, Khan P, Banda L, Chiwaya A, Pereira RP, McNerney R, Harris D, Parkhill J, Clark TG, Glynn JR
J Infect Dis 2015 Apr 1;211(7):1154-63. Epub 2014 Oct 21 doi: 10.1093/infdis/jiu574. [Epub ahead of print] PMID: 25336729Free PMC Article
Huaman MA, Fiske CT, Jones TF, Warkentin J, Shepherd BE, Ingram LA, Maruri F, Sterling TR
Epidemiol Infect 2015 Apr;143(5):951-9. Epub 2014 Aug 22 doi: 10.1017/S0950268814002131. [Epub ahead of print] PMID: 25148655Free PMC Article
Starke JR; Committee On Infectious Diseases
Pediatrics 2014 Dec;134(6):e1763-73. doi: 10.1542/peds.2014-2983. PMID: 25422024

Clinical prediction guides

Patel MR, Westreich D, Yotebieng M, Nana M, Eron JJ, Behets F, Van Rie A
Am J Epidemiol 2015 May 1;181(9):714-22. Epub 2015 Mar 18 doi: 10.1093/aje/kwu338. [Epub ahead of print] PMID: 25787266Free PMC Article
Nguyen HT, Hickson RI, Kompas T, Mercer GN, Lokuge KM
Value Health 2015 Mar;18(2):180-8. Epub 2015 Jan 13 doi: 10.1016/j.jval.2014.11.008. [Epub ahead of print] PMID: 25773553
Ravimohan S, Tamuhla N, Steenhoff AP, Letlhogile R, Nfanyana K, Bellamy SL, MacGregor RR, Gross R, Weissman D, Bisson GP
Lancet Infect Dis 2015 Apr;15(4):429-38. Epub 2015 Feb 9 doi: 10.1016/S1473-3099(15)70008-3. [Epub ahead of print] PMID: 25672566
Stucki D, Ballif M, Bodmer T, Coscolla M, Maurer AM, Droz S, Butz C, Borrell S, Längle C, Feldmann J, Furrer H, Mordasini C, Helbling P, Rieder HL, Egger M, Gagneux S, Fenner L
J Infect Dis 2015 Apr 15;211(8):1306-16. Epub 2014 Oct 30 doi: 10.1093/infdis/jiu601. [Epub ahead of print] PMID: 25362193Free PMC Article
Starke JR; Committee On Infectious Diseases
Pediatrics 2014 Dec;134(6):e1763-73. doi: 10.1542/peds.2014-2983. PMID: 25422024

Recent systematic reviews

Post JJ, Goldberg H, Kaufman G, Plit M, Ressler KA, Ferson MJ
Med J Aust 2015 Mar 16;202(5):255-7. PMID: 25758696
Roy A, Eisenhut M, Harris RJ, Rodrigues LC, Sridhar S, Habermann S, Snell L, Mangtani P, Adetifa I, Lalvani A, Abubakar I
BMJ 2014 Aug 5;349:g4643. PMID: 25097193Free PMC Article
Murray CJ, Ortblad KF, Guinovart C, Lim SS, Wolock TM, Roberts DA, Dansereau EA, Graetz N, Barber RM, Brown JC, Wang H, Duber HC, Naghavi M, Dicker D, Dandona L, Salomon JA, Heuton KR, Foreman K, Phillips DE, Fleming TD, Flaxman AD, Phillips BK, Johnson EK, Coggeshall MS, Abd-Allah F, Abera SF, Abraham JP, Abubakar I, Abu-Raddad LJ, Abu-Rmeileh NM, Achoki T, Adeyemo AO, Adou AK, Adsuar JC, Agardh EE, Akena D, Al Kahbouri MJ, Alasfoor D, Albittar MI, Alcalá-Cerra G, Alegretti MA, Alemu ZA, Alfonso-Cristancho R, Alhabib S, Ali R, Alla F, Allen PJ, Alsharif U, Alvarez E, Alvis-Guzman N, Amankwaa AA, Amare AT, Amini H, Ammar W, Anderson BO, Antonio CA, Anwari P, Arnlöv J, Arsenijevic VS, Artaman A, Asghar RJ, Assadi R, Atkins LS, Badawi A, Balakrishnan K, Banerjee A, Basu S, Beardsley J, Bekele T, Bell ML, Bernabe E, Beyene TJ, Bhala N, Bhalla A, Bhutta ZA, Abdulhak AB, Binagwaho A, Blore JD, Basara BB, Bose D, Brainin M, Breitborde N, Castañeda-Orjuela CA, Catalá-López F, Chadha VK, Chang JC, Chiang PP, Chuang TW, Colomar M, Cooper LT, Cooper C, Courville KJ, Cowie BC, Criqui MH, Dandona R, Dayama A, De Leo D, Degenhardt L, Del Pozo-Cruz B, Deribe K, Des Jarlais DC, Dessalegn M, Dharmaratne SD, Dilmen U, Ding EL, Driscoll TR, Durrani AM, Ellenbogen RG, Ermakov SP, Esteghamati A, Faraon EJ, Farzadfar F, Fereshtehnejad SM, Fijabi DO, Forouzanfar MH, Fra Paleo U, Gaffikin L, Gamkrelidze A, Gankpé FG, Geleijnse JM, Gessner BD, Gibney KB, Ginawi IA, Glaser EL, Gona P, Goto A, Gouda HN, Gugnani HC, Gupta R, Gupta R, Hafezi-Nejad N, Hamadeh RR, Hammami M, Hankey GJ, Harb HL, Haro JM, Havmoeller R, Hay SI, Hedayati MT, Pi IB, Hoek HW, Hornberger JC, Hosgood HD, Hotez PJ, Hoy DG, Huang JJ, Iburg KM, Idrisov BT, Innos K, Jacobsen KH, Jeemon P, Jensen PN, Jha V, Jiang G, Jonas JB, Juel K, Kan H, Kankindi I, Karam NE, Karch A, Karema CK, Kaul A, Kawakami N, Kazi DS, Kemp AH, Kengne AP, Keren A, Kereselidze M, Khader YS, Khalifa SE, Khan EA, Khang YH, Khonelidze I, Kinfu Y, Kinge JM, Knibbs L, Kokubo Y, Kosen S, Defo BK, Kulkarni VS, Kulkarni C, Kumar K, Kumar RB, Kumar GA, Kwan GF, Lai T, Balaji AL, Lam H, Lan Q, Lansingh VC, Larson HJ, Larsson A, Lee JT, Leigh J, Leinsalu M, Leung R, Li Y, Li Y, De Lima GM, Lin HH, Lipshultz SE, Liu S, Liu Y, Lloyd BK, Lotufo PA, Machado VM, Maclachlan JH, Magis-Rodriguez C, Majdan M, Mapoma CC, Marcenes W, Marzan MB, Masci JR, Mashal MT, Mason-Jones AJ, Mayosi BM, Mazorodze TT, Mckay AC, Meaney PA, Mehndiratta MM, Mejia-Rodriguez F, Melaku YA, Memish ZA, Mendoza W, Miller TR, Mills EJ, Mohammad KA, Mokdad AH, Mola GL, Monasta L, Montico M, Moore AR, Mori R, Moturi WN, Mukaigawara M, Murthy KS, Naheed A, Naidoo KS, Naldi L, Nangia V, Narayan KM, Nash D, Nejjari C, Nelson RG, Neupane SP, Newton CR, Ng M, Nisar MI, Nolte S, Norheim OF, Nowaseb V, Nyakarahuka L, Oh IH, Ohkubo T, Olusanya BO, Omer SB, Opio JN, Orisakwe OE, Pandian JD, Papachristou C, Caicedo AJ, Patten SB, Paul VK, Pavlin BI, Pearce N, Pereira DM, Pervaiz A, Pesudovs K, Petzold M, Pourmalek F, Qato D, Quezada AD, Quistberg DA, Rafay A, Rahimi K, Rahimi-Movaghar V, Ur Rahman S, Raju M, Rana SM, Razavi H, Reilly RQ, Remuzzi G, Richardus JH, Ronfani L, Roy N, Sabin N, Saeedi MY, Sahraian MA, Samonte GM, Sawhney M, Schneider IJ, Schwebel DC, Seedat S, Sepanlou SG, Servan-Mori EE, Sheikhbahaei S, Shibuya K, Shin HH, Shiue I, Shivakoti R, Sigfusdottir ID, Silberberg DH, Silva AP, Simard EP, Singh JA, Skirbekk V, Sliwa K, Soneji S, Soshnikov SS, Sreeramareddy CT, Stathopoulou VK, Stroumpoulis K, Swaminathan S, Sykes BL, Tabb KM, Talongwa RT, Tenkorang EY, Terkawi AS, Thomson AJ, Thorne-Lyman AL, Towbin JA, Traebert J, Tran BX, Dimbuene ZT, Tsilimbaris M, Uchendu US, Ukwaja KN, Uzun SB, Vallely AJ, Vasankari TJ, Venketasubramanian N, Violante FS, Vlassov VV, Vollset SE, Waller S, Wallin MT, Wang L, Wang X, Wang Y, Weichenthal S, Weiderpass E, Weintraub RG, Westerman R, White RA, Wilkinson JD, Williams TN, Woldeyohannes SM, Wong JQ, Xu G, Yang YC, Yano Y, Yentur GK, Yip P, Yonemoto N, Yoon SJ, Younis M, Yu C, Jin KY, El Sayed Zaki M, Zhao Y, Zheng Y, Zhou M, Zhu J, Zou XN, Lopez AD, Vos T
Lancet 2014 Sep 13;384(9947):1005-70. Epub 2014 Jul 22 doi: 10.1016/S0140-6736(14)60844-8. [Epub ahead of print] PMID: 25059949Free PMC Article
Souto A, Maneiro JR, Salgado E, Carmona L, Gomez-Reino JJ
Rheumatology (Oxford) 2014 Oct;53(10):1872-85. Epub 2014 May 11 doi: 10.1093/rheumatology/keu172. [Epub ahead of print] PMID: 24821849
Jørgensen ME, Faurholt-Jepsen D
Curr Diab Rep 2014 Jul;14(7):505. doi: 10.1007/s11892-014-0505-1. PMID: 24806518

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