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Results: 7

1.

varenicline

A partial agonist of the nicotinic acetylcholine receptor (nAChR) subtype alpha4beta2. Nicotine stimulation of central alpha4beta2 nAChRs located at presynaptic terminals in the nucleus accumbens causes the release of the neurotransmitter dopamine, which may be associated with the experience of pleasure; nicotine addiction constitutes a physiologic dependence related to this dopaminergic reward system. As an AChR partial agonist, varenicline attenuates the craving and withdrawal symptoms that occur with abstinence from nicotine but is not habit-forming itself. [from NCI]

MedGen UID:
292288
Concept ID:
C1569608
Pharmacologic Substance
2.

Bupropion

A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment. [from MeSH]

MedGen UID:
38816
Concept ID:
C0085208
Pharmacologic Substance
3.

Nicotine

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. [from MeSH]

MedGen UID:
18039
Concept ID:
C0028040
Pharmacologic Substance
4.

Zyntabac

MedGen UID:
304558
Concept ID:
C1450942
Pharmacologic Substance
5.

Quomen

MedGen UID:
260269
Concept ID:
C1450941
Pharmacologic Substance
6.

Nicorette

MedGen UID:
148761
Concept ID:
C0701400
Pharmacologic Substance
7.

Wellbutrin

a depression treatment drug [from CHV]

MedGen UID:
39143
Concept ID:
C0085934
Pharmacologic Substance

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