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Results: 5

1.

Proton Pump Inhibitors

Any one of the substituted benzimidazole compounds with anti-ulcer activity. A proton pump inhibitor is orally administered in the neutrally charged, inactive form and, upon entering the acidic environment of the parietal cell, gets protonated and converted into its active form. The active form will covalently and irreversibly bind to the proton pump, the H+/K+-ATPase, located on the surface of parietal cells. This leads to an inhibition of the transport of hydrogen ions, in exchange for potassium ions, into the gastric lumen and results in an inhibition of gastric acid secretion. [from NCI]

MedGen UID:
87634
Concept ID:
C0358591
Pharmacologic Substance
2.

Disease

Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function. [from NCI]

MedGen UID:
4347
Concept ID:
C0012634
Disease or Syndrome
3.

Reflux

The term used when liquid backs up into the esophagus from the stomach. [from NCI]

MedGen UID:
66675
Concept ID:
C0232483
Pathologic Function
4.

Peptic reflux disease

INFLAMMATION of the ESOPHAGUS that is caused by the reflux of GASTRIC JUICE with contents of the STOMACH and DUODENUM. [from MeSH]

MedGen UID:
5028
Concept ID:
C0014869
Disease or Syndrome
5.

Erosive esophagitis

MedGen UID:
540356
Concept ID:
C0267055
Disease or Syndrome

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