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Results: 1 to 20 of 21

1.

DNA damage

Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS. [from MeSH]

MedGen UID:
3880
Concept ID:
C0012860
Cell or Molecular Dysfunction
2.

Proliferation

Growth and reproduction of new similar forms, e.g. cells, buds, or offspring. [from NCI]

MedGen UID:
137720
Concept ID:
C0334094
Pathologic Function
3.

Oxygen

An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. [from MeSH]

MedGen UID:
45267
Concept ID:
C0030054
Pharmacologic Substance
4.

Oxidative phosphorylation

Electron transfer through the cytochrome system liberating free energy which is transformed into high-energy phosphate bonds. [from MeSH]

MedGen UID:
45265
Concept ID:
C0030013
Molecular Function
5.

Phosphorylation

A process in which a phosphate group is added to a molecule, such as a sugar or a protein. [from NCI]

MedGen UID:
10742
Concept ID:
C0031715
Molecular Function
6.

Related

MedGen UID:
619805
Concept ID:
C0445223
Finding
7.

Metabolic Networks and Pathways

Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites. [from MeSH]

MedGen UID:
328456
Concept ID:
C1721099
Molecular Function
8.

Biochemical Processes

Chemical reactions or functions, enzymatic activities, and metabolic pathways of living things. [from MeSH]

MedGen UID:
267723
Concept ID:
C1511130
Molecular Function
9.

NSC-38297

MedGen UID:
163893
Concept ID:
C0878530
Pharmacologic Substance
10.

Murine

MedGen UID:
108834
Concept ID:
C0591833
Pharmacologic Substance
11.

Diagnosis

The process of identifying a disease, such as cancer, from its signs and symptoms. [from NCI]

MedGen UID:
8354
Concept ID:
C0011900
Finding
12.

Alkaloid

A member of a large group of substances found in plants and in some fungi. Alkaloids contain nitrogen and can be made in the laboratory. Nicotine, caffeine, codeine, and vincristine are alkaloids. Some alkaloids, such as vincristine, are used to treat cancer. [from NCI]

MedGen UID:
7968
Concept ID:
C0002062
Pharmacologic Substance
13.

Male gender

A person who belongs to the sex that normally produces sperm. The term is used to indicate biological sex distinctions, cultural gender role distinctions, or both. (NCI) [from NCI]

MedGen UID:
7446
Concept ID:
C0024554
Finding
14.

Colchicine

A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE). [from MeSH]

MedGen UID:
3148
Concept ID:
C0009262
Pharmacologic Substance
15.

Bromodeoxyuridine

A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors. [from MeSH]

MedGen UID:
2358
Concept ID:
C0006233
Pharmacologic Substance
16.

Adverse reaction to biological substance

MedGen UID:
754846
Concept ID:
C2959665
Finding
17.

Antimetabolite adverse reaction

MedGen UID:
653307
Concept ID:
C0569508
Finding
18.

Skin antiviral agent

MedGen UID:
551153
Concept ID:
C0304589
Pharmacologic Substance
19.

Skin anti-infective, NOS

MedGen UID:
551147
Concept ID:
C0304580
Pharmacologic Substance
20.

Uv-induced skin damage, susceptibility to

MedGen UID:
394510
Concept ID:
C2678403
Finding

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