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Leiomyosarcoma

MedGen UID:
9711
Concept ID:
C0023269
Neoplastic Process
Synonyms: Leiomyosarcomas
SNOMED CT: LMS - Leiomyosarcoma (51549004); Leiomyosarcoma, no subtype (51549004); Leiomyosarcoma (443719001); Leiomyosarcoma (51549004)
 
HPO: HP:0100243
Orphanet: ORPHA64720

Definition

A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865) [from MeSH]

Recent clinical studies

Etiology

Pautier P, Floquet A, Chevreau C, Penel N, Guillemet C, Delcambre C, Cupissol D, Selle F, Isambert N, Piperno-Neumann S, Thyss A, Bertucci F, Bompas E, Alexandre J, Collard O, Lavau-Denes S, Soulié P, Toulmonde M, Le Cesne A, Lacas B, Duffaud F; French Sarcoma Group
Lancet Oncol 2015 Apr;16(4):457-64. Epub 2015 Mar 18 doi: 10.1016/S1470-2045(15)70070-7. [Epub ahead of print] PMID: 25795402
Wachtel H, Jackson BM, Bartlett EK, Karakousis GC, Roses RE, Bavaria JE, Fraker DL
J Surg Oncol 2015 Mar;111(3):328-33. Epub 2014 Oct 8 doi: 10.1002/jso.23798. [Epub ahead of print] PMID: 25297650
Liau JY, Tsai JH, Jeng YM, Lee JC, Hsu HH, Yang CY
Am J Surg Pathol 2015 Feb;39(2):236-44. doi: 10.1097/PAS.0000000000000324. PMID: 25229770
Duska LR, Blessing JA, Rotmensch J, Mannel RS, Hanjani P, Rose PG, Dizon DS
Gynecol Oncol 2014 Oct;135(1):44-8. Epub 2014 Aug 1 doi: 10.1016/j.ygyno.2014.07.101. [Epub ahead of print] PMID: 25091619
Sato K, Yuasa N, Fujita M, Fukushima Y
Am J Obstet Gynecol 2014 Apr;210(4):368.e1-8. Epub 2013 Dec 22 doi: 10.1016/j.ajog.2013.12.028. [Epub ahead of print] PMID: 24368137

Diagnosis

Ciurea ME, Georgescu CV, Radu CC, Georgescu CC, Stoica LE
J Med Life 2014 Jun 15;7(2):270-3. Epub 2014 Jun 25 PMID: 25408738Free PMC Article
Baltz RG, Kaley JR, Hull CA, Gardner JM
J Cutan Pathol 2014 Aug;41(8):680-5. Epub 2014 Apr 29 doi: 10.1111/cup.12329. [Epub ahead of print] PMID: 24628578
Sato K, Yuasa N, Fujita M, Fukushima Y
Am J Obstet Gynecol 2014 Apr;210(4):368.e1-8. Epub 2013 Dec 22 doi: 10.1016/j.ajog.2013.12.028. [Epub ahead of print] PMID: 24368137
Fremed DI, Faries PL, Schanzer HR, Marin ML, Ting W
Vascular 2014 Dec;22(6):450-3. Epub 2013 Dec 17 doi: 10.1177/1708538113516446. [Epub ahead of print] PMID: 24347138
Zhang BH, Zhang HT, Wang YG
Dis Esophagus 2014 Aug;27(6):547-51. Epub 2012 Nov 16 doi: 10.1111/j.1442-2050.2012.01444.x. [Epub ahead of print] PMID: 23163522

Therapy

Pautier P, Floquet A, Chevreau C, Penel N, Guillemet C, Delcambre C, Cupissol D, Selle F, Isambert N, Piperno-Neumann S, Thyss A, Bertucci F, Bompas E, Alexandre J, Collard O, Lavau-Denes S, Soulié P, Toulmonde M, Le Cesne A, Lacas B, Duffaud F; French Sarcoma Group
Lancet Oncol 2015 Apr;16(4):457-64. Epub 2015 Mar 18 doi: 10.1016/S1470-2045(15)70070-7. [Epub ahead of print] PMID: 25795402
Bogani G, Cliby WA, Aletti GD
Gynecol Oncol 2015 Apr;137(1):167-72. Epub 2014 Nov 20 doi: 10.1016/j.ygyno.2014.11.011. [Epub ahead of print] PMID: 25462199
Gaumann AK, Drexler HC, Lang SA, Stoeltzing O, Diermeier-Daucher S, Buchdunger E, Wood J, Bold G, Breier G
Int J Oncol 2014 Dec;45(6):2267-77. Epub 2014 Sep 29 doi: 10.3892/ijo.2014.2683. [Epub ahead of print] PMID: 25340839Free PMC Article
Duska LR, Blessing JA, Rotmensch J, Mannel RS, Hanjani P, Rose PG, Dizon DS
Gynecol Oncol 2014 Oct;135(1):44-8. Epub 2014 Aug 1 doi: 10.1016/j.ygyno.2014.07.101. [Epub ahead of print] PMID: 25091619
Sagara K, Takayoshi K, Kusumoto E, Uchino K, Matsumura T, Kusaba H, Momosaki S, Ikejiri K, Baba E
BMC Res Notes 2014 Jun 19;7:377. doi: 10.1186/1756-0500-7-377. [Epub ahead of print] PMID: 24947892Free PMC Article

Prognosis

Pautier P, Floquet A, Chevreau C, Penel N, Guillemet C, Delcambre C, Cupissol D, Selle F, Isambert N, Piperno-Neumann S, Thyss A, Bertucci F, Bompas E, Alexandre J, Collard O, Lavau-Denes S, Soulié P, Toulmonde M, Le Cesne A, Lacas B, Duffaud F; French Sarcoma Group
Lancet Oncol 2015 Apr;16(4):457-64. Epub 2015 Mar 18 doi: 10.1016/S1470-2045(15)70070-7. [Epub ahead of print] PMID: 25795402
Wachtel H, Jackson BM, Bartlett EK, Karakousis GC, Roses RE, Bavaria JE, Fraker DL
J Surg Oncol 2015 Mar;111(3):328-33. Epub 2014 Oct 8 doi: 10.1002/jso.23798. [Epub ahead of print] PMID: 25297650
Liau JY, Tsai JH, Jeng YM, Lee JC, Hsu HH, Yang CY
Am J Surg Pathol 2015 Feb;39(2):236-44. doi: 10.1097/PAS.0000000000000324. PMID: 25229770
Ciurea ME, Georgescu CV, Radu CC, Georgescu CC, Stoica LE
J Med Life 2014 Jun 15;7(2):270-3. Epub 2014 Jun 25 PMID: 25408738Free PMC Article
Baltz RG, Kaley JR, Hull CA, Gardner JM
J Cutan Pathol 2014 Aug;41(8):680-5. Epub 2014 Apr 29 doi: 10.1111/cup.12329. [Epub ahead of print] PMID: 24628578

Clinical prediction guides

Bogani G, Cliby WA, Aletti GD
Gynecol Oncol 2015 Apr;137(1):167-72. Epub 2014 Nov 20 doi: 10.1016/j.ygyno.2014.11.011. [Epub ahead of print] PMID: 25462199
Liau JY, Tsai JH, Jeng YM, Lee JC, Hsu HH, Yang CY
Am J Surg Pathol 2015 Feb;39(2):236-44. doi: 10.1097/PAS.0000000000000324. PMID: 25229770
Gaumann AK, Drexler HC, Lang SA, Stoeltzing O, Diermeier-Daucher S, Buchdunger E, Wood J, Bold G, Breier G
Int J Oncol 2014 Dec;45(6):2267-77. Epub 2014 Sep 29 doi: 10.3892/ijo.2014.2683. [Epub ahead of print] PMID: 25340839Free PMC Article
Galosi AB, Scarpelli M, Mazzucchelli R, Lopez-Beltran A, Giustini L, Cheng L, Montironi R
Diagn Pathol 2014 May 6;9:90. doi: 10.1186/1746-1596-9-90. [Epub ahead of print] PMID: 24885500Free PMC Article
Sato K, Yuasa N, Fujita M, Fukushima Y
Am J Obstet Gynecol 2014 Apr;210(4):368.e1-8. Epub 2013 Dec 22 doi: 10.1016/j.ajog.2013.12.028. [Epub ahead of print] PMID: 24368137

Recent systematic reviews

Bogani G, Cliby WA, Aletti GD
Gynecol Oncol 2015 Apr;137(1):167-72. Epub 2014 Nov 20 doi: 10.1016/j.ygyno.2014.11.011. [Epub ahead of print] PMID: 25462199
Pritts EA, Parker WH, Brown J, Olive DL
J Minim Invasive Gynecol 2015 Jan;22(1):26-33. Epub 2014 Sep 3 doi: 10.1016/j.jmig.2014.08.781. [Epub ahead of print] PMID: 25193444
Xu J, Zhang T, Wang T, You L, Zhao Y
World J Surg Oncol 2013 Nov 12;11:290. doi: 10.1186/1477-7819-11-290. [Epub ahead of print] PMID: 24219646Free PMC Article
Gupta AA, Yao X, Verma S, Mackay H, Hopkins L; Sarcoma Disease Site Group and the Gynecology Cancer Disease Site Group
Clin Oncol (R Coll Radiol) 2013 Jun;25(6):346-55. Epub 2013 Jan 5 doi: 10.1016/j.clon.2012.11.008. [Epub ahead of print] PMID: 23295078
Eppsteiner RW, DeYoung BR, Milhem MM, Pagedar NA
Arch Otolaryngol Head Neck Surg 2011 Sep;137(9):921-4. doi: 10.1001/archoto.2011.147. PMID: 21930982Free PMC Article

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