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metaplastic cell transformation

MedGen UID:
266929
Concept ID:
C1510411
Pathologic Function
Synonyms: Cell Transformation; Cellular Transformation; transformation; Transformation; Transformed; Transforming
 

Definition

The conversion of a cell from a normal phenotype, which undergoes a limited number of mitotic divisions, into an aberrant phenotype that is immortal and divides indefinitely. Transformed cells no longer retain cell-cycle checkpoints and may ultimately become malignant cancer cells via additional genetic mutations, or damaging environmental events. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGmetaplastic cell transformation

Recent clinical studies

Etiology

Pinho AV, Chantrill L, Rooman I
Cancer Lett 2014 Apr 10;345(2):203-9. Epub 2013 Aug 24 doi: 10.1016/j.canlet.2013.08.015. [Epub ahead of print] PMID: 23981573
Somja J, Demoulin S, Roncarati P, Herfs M, Bletard N, Delvenne P, Hubert P
Am J Pathol 2013 Jun;182(6):2168-79. Epub 2013 Apr 22 doi: 10.1016/j.ajpath.2013.02.036. [Epub ahead of print] PMID: 23619476
Zampeli E, Karamanolis G, Morfopoulos G, Xirouchakis E, Kalampoki V, Michopoulos S, Savva S, Tzias V, Zouboulis-Vafiadis I, Kamberoglou D, Ladas SD
Dig Dis Sci 2012 May;57(5):1190-6. Epub 2011 Dec 7 doi: 10.1007/s10620-011-1990-6. [Epub ahead of print] PMID: 22147251
Matoso A, Easley SE, Mangray S, Jacob R, DeLellis RA
Appl Immunohistochem Mol Morphol 2011 Oct;19(5):400-7. doi: 10.1097/PAI.0b013e31820793a7. PMID: 21297445
Majka J, Rembiasz K, Migaczewski M, Budzynski A, Ptak-Belowska A, Pabianczyk R, Urbanczyk K, Zub-Pokrowiecka A, Matlok M, Brzozowski T
J Physiol Pharmacol 2010 Aug;61(4):409-18. PMID: 20814068

Diagnosis

Tanaka Y, Koie T, Hatakeyama S, Hashimoto Y, Ohyama C
BMC Urol 2013 Dec 13;13:72. doi: 10.1186/1471-2490-13-72. [Epub ahead of print] PMID: 24330625Free PMC Article
Pan Q, Nicholson AM, Barr H, Harrison LA, Wilson GD, Burkert J, Jeffery R, Alison MR, Looijenga L, Lin WR, McDonald SA, Wright NA, Harrison R, Peppelenbosch MP, Jankowski JA
Gastroenterology 2013 Apr;144(4):761-70. Epub 2012 Dec 22 doi: 10.1053/j.gastro.2012.12.022. [Epub ahead of print] PMID: 23266557
Al-Marzoqee FY, Khoder G, Al-Awadhi H, John R, Beg A, Vincze A, Branicki F, Karam SM
Int J Oncol 2012 Nov;41(5):1733-43. Epub 2012 Aug 24 doi: 10.3892/ijo.2012.1608. [Epub ahead of print] PMID: 22922943
Matoso A, Easley SE, Mangray S, Jacob R, DeLellis RA
Appl Immunohistochem Mol Morphol 2011 Oct;19(5):400-7. doi: 10.1097/PAI.0b013e31820793a7. PMID: 21297445
Aldenborg F, Peeker R, Fall M, Olofsson A, Enerbäck L
Am J Pathol 1998 Jul;153(1):149-57. doi: 10.1016/S0002-9440(10)65555-1. PMID: 9665475Free PMC Article

Therapy

Pinho AV, Chantrill L, Rooman I
Cancer Lett 2014 Apr 10;345(2):203-9. Epub 2013 Aug 24 doi: 10.1016/j.canlet.2013.08.015. [Epub ahead of print] PMID: 23981573
Talmon GA, Wisecarver JL
Pediatr Transplant 2011 Mar;15(2):E34-7. doi: 10.1111/j.1399-3046.2009.01240.x. PMID: 20003139
Hayes MM, Lesack D, Girardet C, Del Vecchio M, Eusebi V
Virchows Arch 2005 Feb;446(2):142-9. Epub 2004 Dec 4 doi: 10.1007/s00428-004-1137-7. [Epub ahead of print] PMID: 15583933
Rao K, Bryant E, O'Hara Larivee S, McDougall JK
Cancer Lett 2003 Nov 10;201(1):79-88. PMID: 14580689
Lapertosa G, Baracchini P, Fulcheri E
Pathologica 1994 Apr;86(2):174-9. PMID: 7936762

Prognosis

Tan PH, Ellis IO
J Clin Pathol 2013 Jun;66(6):465-70. Epub 2013 Mar 26 doi: 10.1136/jclinpath-2012-201078. [Epub ahead of print] PMID: 23533258
Heid I, Lubeseder-Martellato C, Sipos B, Mazur PK, Lesina M, Schmid RM, Siveke JT
Gastroenterology 2011 Aug;141(2):719-30, 730.e1-7. Epub 2011 Apr 28 doi: 10.1053/j.gastro.2011.04.043. [Epub ahead of print] PMID: 21684285
Wen J, Park JY, Park KH, Chung HW, Bang S, Park SW, Song SY
Pancreas 2010 Jul;39(5):622-6. doi: 10.1097/MPA.0b013e3181c75f5e. PMID: 20173672
Calabrese F, Lunardi F, Giacometti C, Marulli G, Gnoato M, Pontisso P, Saetta M, Valente M, Rea F, Perissinotto E, Agostini C
Thorax 2008 Sep;63(9):795-802. Epub 2008 Mar 14 doi: 10.1136/thx.2007.088583. [Epub ahead of print] PMID: 18344408
Lien HC, Hsiao YH, Lin YS, Yao YT, Juan HF, Kuo WH, Hung MC, Chang KJ, Hsieh FJ
Oncogene 2007 Dec 13;26(57):7859-71. Epub 2007 Jul 2 doi: 10.1038/sj.onc.1210593. [Epub ahead of print] PMID: 17603561

Clinical prediction guides

Somja J, Demoulin S, Roncarati P, Herfs M, Bletard N, Delvenne P, Hubert P
Am J Pathol 2013 Jun;182(6):2168-79. Epub 2013 Apr 22 doi: 10.1016/j.ajpath.2013.02.036. [Epub ahead of print] PMID: 23619476
Rotellini M, Paglierani M, Pepi M, Franchi A
J Oral Pathol Med 2012 Sep;41(8):615-20. Epub 2012 May 15 doi: 10.1111/j.1600-0714.2012.01159.x. [Epub ahead of print] PMID: 22582766
Nicholson AM, Graham TA, Simpson A, Humphries A, Burch N, Rodriguez-Justo M, Novelli M, Harrison R, Wright NA, McDonald SA, Jankowski JA
Gut 2012 Oct;61(10):1380-9. Epub 2011 Dec 26 doi: 10.1136/gutjnl-2011-301174. [Epub ahead of print] PMID: 22200839
van Deurzen CH, Lee AH, Gill MS, Menke-Pluijmers MB, Jager A, Ellis IO, Rakha EA
J Pathol 2011 Aug;224(4):434-7. Epub 2011 Apr 1 doi: 10.1002/path.2872. [Epub ahead of print] PMID: 21462188
Herfs M, Hubert P, Delvenne P
Trends Mol Med 2009 Jun;15(6):245-53. Epub 2009 May 18 doi: 10.1016/j.molmed.2009.04.002. [Epub ahead of print] PMID: 19457719

Recent systematic reviews

McGoogan E, Colgan TJ, Ramzy I, Cochand-Priollet B, Davey DD, Grohs HK, Gurley AM, Husain OA, Hutchinson ML, Knesel EA Jr, Linder J, Mango LJ, Mitchell H, Peebles A, Reith A, Robinowitz M, Sauer T, Shida S, Solomon D, Topalidis T, Wilbur DC, Yamauchi K
Acta Cytol 1998 Jan-Feb;42(1):25-32. PMID: 9479321

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