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1.

Lipase

An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. It is produced by glands on the tongue and by the pancreas and initiates the digestion of dietary fats. (From Dorland, 27th ed) EC 3.1.1.3. [from MeSH]

MedGen UID:
9778
Concept ID:
C0023764
Pharmacologic Substance
2.

Obesity

Obesity means having too much body fat. It is different from being overweight, which means weighing too much. The weight may come from muscle, bone, fat, and/or body water. Both terms mean that a person's weight is greater than what's considered healthy for his or her height. . Obesity occurs over time when you eat more calories than you use. The balance between calories-in and calories-out differs for each person. Factors that might affect your weight include your genetic makeup, overeating, eating high-fat foods, and not being physically active. . Being obese increases your risk of diabetes, heart disease, stroke, arthritis, and some cancers. If you are obese, losing even 5 to 10 percent of your weight can delay or prevent some of these diseases. For example, that means losing 10 to 20 pounds if you weigh 200 pounds. NIH: National Institute of Diabetes and Digestive and Kidney Diseases.  [from MedlinePlus]

MedGen UID:
18127
Concept ID:
C0028754
Disease or Syndrome
3.

Fat

The glyceryl esters of a fatty acid, or of a mixture of fatty acids. They are generally odorless, colorless, and tasteless if pure, but they may be flavored according to origin. Fats are insoluble in water, soluble in most organic solvents. They occur in animal and vegetable tissue and are generally obtained by boiling or by extraction under pressure. They are important in the diet (DIETARY FATS) as a source of energy. (Grant & Hackh's Chemical Dictionary, 5th ed) [from MeSH]

MedGen UID:
5132
Concept ID:
C0015677
Pharmacologic Substance
4.

orlistat

A reversible active-site inhibitor of gastrointestinal lipases. Orlistat forms a covalent bond with the active serine site in gastric and pancreatic lipases, thereby inhibiting their activity and preventing dietary fat from being hydrolyzed and absorbed. (NCI04) [from NCI]

MedGen UID:
23289
Concept ID:
C0076275
Pharmacologic Substance
5.

Triolein

(Z)-9-Octadecenoic acid 1,2,3-propanetriyl ester. [from MeSH]

MedGen UID:
21695
Concept ID:
C0041073
Pharmacologic Substance
6.

Oleic Acid

An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed) [from MeSH]

MedGen UID:
14468
Concept ID:
C0028928
Pharmacologic Substance
7.

lipase inhibitor

MedGen UID:
692699
Concept ID:
C1268854
Pharmacologic Substance
8.

Nutritional disorder

Disorders caused by nutritional imbalance, either overnutrition or undernutrition. [from MeSH]

MedGen UID:
811347
Concept ID:
C3714509
Disease or Syndrome
9.

Disorder of hyperalimentation

An imbalanced nutritional status resulted from excessive intake of nutrients. Generally, overnutrition generates an energy imbalance between food consumption and energy expenditure leading to disorders such as OBESITY. [from MeSH]

MedGen UID:
219760
Concept ID:
C1257763
Disease or Syndrome
10.

Oleate

MedGen UID:
113127
Concept ID:
C0220884
Pharmacologic Substance
11.

Overweight

BMI 25 [from CHV]

MedGen UID:
105424
Concept ID:
C0497406
Sign or Symptom
12.

Nutritional and Metabolic Diseases

A collective term for nutritional disorders resulting from poor absorption or nutritional imbalance, and metabolic disorders resulting from defects in biosynthesis (ANABOLISM) or breakdown (CATABOLISM) of endogenous substances. [from MeSH]

MedGen UID:
45164
Concept ID:
C0028715
Disease or Syndrome
13.

Nutrition Disorders

MedGen UID:
45163
Concept ID:
C0028709
Disease or Syndrome
14.

Pathological Conditions, Signs and Symptoms

Abnormal anatomical or physiological conditions and objective or subjective manifestations of disease, not classified as disease or syndrome. [from MeSH]

MedGen UID:
21047
Concept ID:
C0039058
Sign or Symptom
15.

Clinical finding

clinical manifestations that can be either objective when observed by a physician, or subjective when perceived by the patient. [from CRISP]

MedGen UID:
19974
Concept ID:
C0037088
Sign or Symptom
16.

Glycerides

glycerol esterified with one or more organic acids, particularly long chain fatty acids. [from CRISP]

MedGen UID:
9055
Concept ID:
C0017860
Pharmacologic Substance
17.

Female

A person who belongs to the sex that normally produces ova. The term is used to indicate biological sex distinctions, or cultural gender role distinctions, or both. (NCI) [from NCI_CDISC]

MedGen UID:
8807
Concept ID:
C0015780
Finding
18.

Diagnosis

The process of identifying a disease, such as cancer, from its signs and symptoms. [from NCI]

MedGen UID:
8354
Concept ID:
C0011900
Finding
19.

Male gender

A person who belongs to the sex that normally produces sperm. The term is used to indicate biological sex distinctions, cultural gender role distinctions, or both. (NCI) [from NCI]

MedGen UID:
7446
Concept ID:
C0024554
Finding
20.

Alli

MedGen UID:
360603
Concept ID:
C1871879
Pharmacologic Substance

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