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triclocarban

MedGen UID:
36802
Concept ID:
C0077072
Pharmacologic Substance
Synonyms: 3,4,4'-trichlorocarbanilide; N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea; trichlorcarban; trichlorocarbanilide
SNOMED CT: Triclocarban (23701001); TCC - Trichlorocarbanilide (23701001); TCC - Trichlorcarbanilide (23701001); Trichlorcarbanilide (23701001); Trichlorocarbanilide (411346009); Trichlorocarbanilide (23701001)
 

Definition

A triclosan analogue with an antibacterial property. Triclocarban exerts its effect by inhibiting the activity of enoyl-(acyl-carrier protein) (ACP) reductase, widely distributed in bacteria, fungi and plants. ACP reductase catalyses the last step in each cycle of fatty acid elongation in the type II fatty acid synthase systems. As a result, this agent interrupts cell membrane synthesis and leads to bacterial growth inhibition. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGtriclocarban

Recent clinical studies

Etiology

Kuehn BM
JAMA 2014 Jan 15;311(3):234. doi: 10.1001/jama.2013.285971. PMID: 24430309
Snyder EH, O'Connor GA
Sci Total Environ 2013 Jan 1;442:437-44. Epub 2012 Nov 24 doi: 10.1016/j.scitotenv.2012.10.007. [Epub ahead of print] PMID: 23183124
Aryal N, Reinhold DM
Water Res 2011 Nov 1;45(17):5545-52. Epub 2011 Aug 23 doi: 10.1016/j.watres.2011.08.027. [Epub ahead of print] PMID: 21903237
Halden RU, Paull DH
Environ Sci Technol 2005 Mar 15;39(6):1420-6. PMID: 15819193
Hoar DR, Bowen MH
J Pharm Sci 1977 May;66(5):725-6. PMID: 874758

Diagnosis

Asimakopoulos AG, Wang L, Thomaidis NS, Kannan K
J Chromatogr A 2014 Jan 10;1324:141-8. Epub 2013 Nov 21 doi: 10.1016/j.chroma.2013.11.031. [Epub ahead of print] PMID: 24315674
Tarnow P, Tralau T, Hunecke D, Luch A
Toxicol In Vitro 2013 Aug;27(5):1467-75. Epub 2013 Mar 21 doi: 10.1016/j.tiv.2013.03.003. [Epub ahead of print] PMID: 23524099
Schebb NH, Buchholz BA, Hammock BD, Rice RH
J Biochem Mol Toxicol 2012 Jun;26(6):230-4. doi: 10.1002/jbt.21411. PMID: 22711420Free PMC Article
Zhou X, Ye X, Calafat AM
J Chromatogr B Analyt Technol Biomed Life Sci 2012 Jan 15;881-882:27-33. Epub 2011 Nov 26 doi: 10.1016/j.jchromb.2011.11.024. [Epub ahead of print] PMID: 22192874
Ahn KC, Kasagami T, Tsai HJ, Schebb NH, Ogunyoku T, Gee SJ, Young TM, Hammock BD
Environ Sci Technol 2012 Jan 3;46(1):374-81. Epub 2011 Dec 8 doi: 10.1021/es202494d. [Epub ahead of print] PMID: 22077920Free PMC Article

Therapy

Sood S, Choudhary S, Wang HC
Biochem Biophys Res Commun 2013 Sep 6;438(4):600-6. Epub 2013 Aug 11 doi: 10.1016/j.bbrc.2013.08.009. [Epub ahead of print] PMID: 23942114Free PMC Article
Liu JY, Qiu H, Morisseau C, Hwang SH, Tsai HJ, Ulu A, Chiamvimonvat N, Hammock BD
Toxicol Appl Pharmacol 2011 Sep 1;255(2):200-6. Epub 2011 Jun 25 doi: 10.1016/j.taap.2011.06.017. [Epub ahead of print] PMID: 21741984Free PMC Article
Ye X, Zhou X, Furr J, Ahn KC, Hammock BD, Gray EL, Calafat AM
Toxicology 2011 Aug 15;286(1-3):69-74. Epub 2011 May 23 doi: 10.1016/j.tox.2011.05.008. [Epub ahead of print] PMID: 21635932Free PMC Article
Halden RU, Paull DH
Environ Sci Technol 2005 Mar 15;39(6):1420-6. PMID: 15819193
Howes D, Black JG
Toxicology 1976 Jun;6(1):67-76. PMID: 941165

Prognosis

Chung E, Genco MC, Megrelis L, Ruderman JV
Proc Natl Acad Sci U S A 2011 Oct 25;108(43):17732-7. Epub 2011 Oct 17 doi: 10.1073/pnas.1115187108. [Epub ahead of print] PMID: 22006313Free PMC Article
Baumann A, Lohmann W, Rose T, Ahn KC, Hammock BD, Karst U, Schebb NH
Drug Metab Dispos 2010 Dec;38(12):2130-8. Epub 2010 Sep 22 doi: 10.1124/dmd.110.034546. [Epub ahead of print] PMID: 20861155Free PMC Article
Halden RU, Paull DH
Environ Sci Technol 2005 Mar 15;39(6):1420-6. PMID: 15819193
Luby S, Agboatwalla M, Schnell BM, Hoekstra RM, Rahbar MH, Keswick BH
Am J Trop Med Hyg 2002 Oct;67(4):430-5. PMID: 12452499
Contact Dermatitis 1978 Oct;4(5):283-8. PMID: 743875

Clinical prediction guides

Asimakopoulos AG, Thomaidis NS, Kannan K
Sci Total Environ 2014 Feb 1;470-471:1243-9. Epub 2013 Nov 16 doi: 10.1016/j.scitotenv.2013.10.089. [Epub ahead of print] PMID: 24246946
Yueh MF, Li T, Evans RM, Hammock B, Tukey RH
PLoS One 2012;7(6):e37705. Epub 2012 Jun 15 doi: 10.1371/journal.pone.0037705. PMID: 22761658Free PMC Article
Schebb NH, Franze B, Maul R, Ranganathan A, Hammock BD
Drug Metab Dispos 2012 Jan;40(1):25-31. Epub 2011 Sep 27 doi: 10.1124/dmd.111.042283. [Epub ahead of print] PMID: 21953915Free PMC Article
Chung E, Genco MC, Megrelis L, Ruderman JV
Proc Natl Acad Sci U S A 2011 Oct 25;108(43):17732-7. Epub 2011 Oct 17 doi: 10.1073/pnas.1115187108. [Epub ahead of print] PMID: 22006313Free PMC Article
Baumann A, Lohmann W, Rose T, Ahn KC, Hammock BD, Karst U, Schebb NH
Drug Metab Dispos 2010 Dec;38(12):2130-8. Epub 2010 Sep 22 doi: 10.1124/dmd.110.034546. [Epub ahead of print] PMID: 20861155Free PMC Article

Recent systematic reviews

Witorsch RJ, Thomas JA
Crit Rev Toxicol 2010 Nov;40 Suppl 3:1-30. doi: 10.3109/10408444.2010.515563. PMID: 20932229

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