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Graft-versus-host disease, susceptibility to(GVHDS)

MedGen UID:
482307
Concept ID:
C3280677
Finding
Synonyms: GVHDS
 
Gene (location): IL10 (1q32.1)
OMIM®: 614395
Orphanet: ORPHA39812

Definition

Transplantation of hematopoietic stem cells is a successful therapy for some tumors derived from bone marrow precursors, such as certain leukemias and lymphomas, and it can be used to cure some primary immunodeficiencies and inherited hematopoietic stem-cell diseases. One of the major complications of allogeneic bone marrow transplantation is graft-versus-host disease (GVHD), in which mature donor T cells that contaminate the allogeneic bone marrow recognize the tissues of the recipient as foreign, causing a severe inflammatory disease characterized by rashes, diarrhea, and liver disease. GVHD is particularly virulent when there is a mismatch of a major major histocompatibility complex (MHC) class I or class II antigen. Most transplants are therefore undertaken only when the donor and recipient are HLA-matched sibs or, less frequently, when there is an HLA-matched unrelated donor. However, GVHD also occurs in the context of disparities between minor histocompatibility antigens, and immunosuppression must be used in every stem-cell transplant (summary by Janeway et al., 2005). At the core of the immunogenetic basis for GVHD is the diversity of HLA, killer immunoglobulin-like receptors (KIRs; see 604936), and cytokine genes. HLA class I molecules function as ligands for natural killer cell inhibitory KIRs, indicating that GVHD results from a complex interplay between innate and adaptive immune responses. Cytokines may modulate the intensity of tissue injury and inflammation in GVHD, and therefore cytokine polymorphisms in either patient or donor or both may explain individual risks of GVHD (review by Petersdorf and Malkki, 2006). [from OMIM]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGraft-versus-host disease, susceptibility to
Follow this link to review classifications for Graft-versus-host disease, susceptibility to in Orphanet.

Recent clinical studies

Etiology

Tsushima F, Sakurai J, Harada H
Aust Dent J 2015 Sep;60(3):404-7. Epub 2015 Jul 24 doi: 10.1111/adj.12343. [Epub ahead of print] PMID: 26211810
Sonntag K, Eckert F, Welker C, Müller H, Müller F, Zips D, Sipos B, Klein R, Blank G, Feuchtinger T, Schumm M, Handgretinger R, Schilbach K
J Autoimmun 2015 Aug;62:55-66. Epub 2015 Jul 3 doi: 10.1016/j.jaut.2015.06.006. [Epub ahead of print] PMID: 26143958
Karabon L, Markiewicz M, Partyka A, Pawlak-Adamska E, Tomkiewicz A, Dzierzak-Mietla M, Kyrcz-Krzemien S, Frydecka I
Immunogenetics 2015 Jun;67(5-6):295-304. Epub 2015 May 5 doi: 10.1007/s00251-015-0840-7. [Epub ahead of print] PMID: 25940108Free PMC Article
Grein Cavalcanti L, Fuentes Araújo RL, Bonfim C, Torres-Pereira CC
Biol Blood Marrow Transplant 2015 Feb;21(2):275-80. Epub 2014 Oct 12 doi: 10.1016/j.bbmt.2014.10.009. [Epub ahead of print] PMID: 25316110
Zhao H, Jia M, Wang Z, Cheng Y, Luo Z, Chen Y, Xu X, Yang S, Tang Y
Hematology 2015 Jun;20(5):254-62. Epub 2014 Sep 23 doi: 10.1179/1607845414Y.0000000202. [Epub ahead of print] PMID: 25248089

Diagnosis

Tong LX, Worswick SD
J Am Acad Dermatol 2015 Apr;72(4):696-702. Epub 2015 Jan 10 doi: 10.1016/j.jaad.2014.12.002. [Epub ahead of print] PMID: 25582535
Grein Cavalcanti L, Fuentes Araújo RL, Bonfim C, Torres-Pereira CC
Biol Blood Marrow Transplant 2015 Feb;21(2):275-80. Epub 2014 Oct 12 doi: 10.1016/j.bbmt.2014.10.009. [Epub ahead of print] PMID: 25316110
Zhao H, Jia M, Wang Z, Cheng Y, Luo Z, Chen Y, Xu X, Yang S, Tang Y
Hematology 2015 Jun;20(5):254-62. Epub 2014 Sep 23 doi: 10.1179/1607845414Y.0000000202. [Epub ahead of print] PMID: 25248089
Cho IH, Song YK, Kim MG, Han N, Kim T, Oh JM
Hematology 2015 Apr;20(3):121-8. Epub 2014 Aug 12 doi: 10.1179/1607845414Y.0000000183. [Epub ahead of print] PMID: 25116082
Calkoen FG, Vervat C, van Halteren AG, Welters MJ, Veltrop-Duits LA, Lankester AC, Egeler RM, Ball LM, van Tol MJ
Stem Cells Transl Med 2014 Aug;3(8):899-910. Epub 2014 Jun 5 doi: 10.5966/sctm.2013-0191. [Epub ahead of print] PMID: 24904175Free PMC Article

Therapy

Tsushima F, Sakurai J, Harada H
Aust Dent J 2015 Sep;60(3):404-7. Epub 2015 Jul 24 doi: 10.1111/adj.12343. [Epub ahead of print] PMID: 26211810
Karabon L, Markiewicz M, Partyka A, Pawlak-Adamska E, Tomkiewicz A, Dzierzak-Mietla M, Kyrcz-Krzemien S, Frydecka I
Immunogenetics 2015 Jun;67(5-6):295-304. Epub 2015 May 5 doi: 10.1007/s00251-015-0840-7. [Epub ahead of print] PMID: 25940108Free PMC Article
Tong LX, Worswick SD
J Am Acad Dermatol 2015 Apr;72(4):696-702. Epub 2015 Jan 10 doi: 10.1016/j.jaad.2014.12.002. [Epub ahead of print] PMID: 25582535
Grein Cavalcanti L, Fuentes Araújo RL, Bonfim C, Torres-Pereira CC
Biol Blood Marrow Transplant 2015 Feb;21(2):275-80. Epub 2014 Oct 12 doi: 10.1016/j.bbmt.2014.10.009. [Epub ahead of print] PMID: 25316110
Munneke JM, Björklund AT, Mjösberg JM, Garming-Legert K, Bernink JH, Blom B, Huisman C, van Oers MH, Spits H, Malmberg KJ, Hazenberg MD
Blood 2014 Jul 31;124(5):812-21. Epub 2014 May 22 doi: 10.1182/blood-2013-11-536888. [Epub ahead of print] PMID: 24855210

Prognosis

Tsushima F, Sakurai J, Harada H
Aust Dent J 2015 Sep;60(3):404-7. Epub 2015 Jul 24 doi: 10.1111/adj.12343. [Epub ahead of print] PMID: 26211810
Bari R, Hartford C, Chan WK, Vong Q, Li Y, Gan K, Zhou Y, Cheng C, Kang G, Shurtleff S, Turner V, Pui CH, Downing JR, Leung W
Sci Rep 2015 Jun 11;5:11098. doi: 10.1038/srep11098. PMID: 26067905Free PMC Article
Tong LX, Worswick SD
J Am Acad Dermatol 2015 Apr;72(4):696-702. Epub 2015 Jan 10 doi: 10.1016/j.jaad.2014.12.002. [Epub ahead of print] PMID: 25582535
Calkoen FG, Vervat C, van Halteren AG, Welters MJ, Veltrop-Duits LA, Lankester AC, Egeler RM, Ball LM, van Tol MJ
Stem Cells Transl Med 2014 Aug;3(8):899-910. Epub 2014 Jun 5 doi: 10.5966/sctm.2013-0191. [Epub ahead of print] PMID: 24904175Free PMC Article
Stern M, de Wreede LC, Brand R, van Biezen A, Dreger P, Mohty M, de Witte TM, Kröger N, Ruutu T
Leukemia 2014 Nov;28(11):2235-40. Epub 2014 Apr 30 doi: 10.1038/leu.2014.145. [Epub ahead of print] PMID: 24781016

Clinical prediction guides

Bari R, Hartford C, Chan WK, Vong Q, Li Y, Gan K, Zhou Y, Cheng C, Kang G, Shurtleff S, Turner V, Pui CH, Downing JR, Leung W
Sci Rep 2015 Jun 11;5:11098. doi: 10.1038/srep11098. PMID: 26067905Free PMC Article
Karabon L, Markiewicz M, Partyka A, Pawlak-Adamska E, Tomkiewicz A, Dzierzak-Mietla M, Kyrcz-Krzemien S, Frydecka I
Immunogenetics 2015 Jun;67(5-6):295-304. Epub 2015 May 5 doi: 10.1007/s00251-015-0840-7. [Epub ahead of print] PMID: 25940108Free PMC Article
Grein Cavalcanti L, Fuentes Araújo RL, Bonfim C, Torres-Pereira CC
Biol Blood Marrow Transplant 2015 Feb;21(2):275-80. Epub 2014 Oct 12 doi: 10.1016/j.bbmt.2014.10.009. [Epub ahead of print] PMID: 25316110
Stern M, de Wreede LC, Brand R, van Biezen A, Dreger P, Mohty M, de Witte TM, Kröger N, Ruutu T
Leukemia 2014 Nov;28(11):2235-40. Epub 2014 Apr 30 doi: 10.1038/leu.2014.145. [Epub ahead of print] PMID: 24781016
Boukouaci W, Al-Daccak R, Dulphy N, Lauden L, Amokrane K, Fortier C, Marzais F, Bennabi M, Peffault de Latour R, Socie G, Toubert A, Charron D, Krishnamoorthy R, Tamouza R
Hum Immunol 2013 Dec;74(12):1536-41. Epub 2013 Aug 29 doi: 10.1016/j.humimm.2013.08.281. [Epub ahead of print] PMID: 23994587

Recent systematic reviews

Zhao H, Jia M, Wang Z, Cheng Y, Luo Z, Chen Y, Xu X, Yang S, Tang Y
Hematology 2015 Jun;20(5):254-62. Epub 2014 Sep 23 doi: 10.1179/1607845414Y.0000000202. [Epub ahead of print] PMID: 25248089
Cho IH, Song YK, Kim MG, Han N, Kim T, Oh JM
Hematology 2015 Apr;20(3):121-8. Epub 2014 Aug 12 doi: 10.1179/1607845414Y.0000000183. [Epub ahead of print] PMID: 25116082
Olausson JM, Hammer MJ, Brady V
Oncol Nurs Forum 2014 Sep;41(5):E302-12. doi: 10.1188/14.ONF.E302-E312. PMID: 25158667
Zhu P, Xie L, Yang Y, Wang J, Gong F, Fang M
Int J Hematol 2013 Jul;98(1):102-11. Epub 2013 May 21 doi: 10.1007/s12185-013-1363-3. [Epub ahead of print] PMID: 23690289
Choi B, Lee DE, Park HY, Jeong S, Lee SM, Ji E, Park S, Oh JM
Clin Ther 2012 Feb;34(2):295-304. Epub 2012 Feb 1 doi: 10.1016/j.clinthera.2012.01.010. [Epub ahead of print] PMID: 22304944

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