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1.

Aging

Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. This notion is supported by the observation of an aging-related accumulation in human mtDNA of oxidative and alkylation derivatives of nucleotides, of small deletions and insertions, and of large deletions, although their low frequency raises questions about their functional significance (Michikawa et al., 1999). [from OMIM]

MedGen UID:
1376
Concept ID:
C0001811
2.

Difficulty walking

We walk thousands of steps each day. We walk to do our daily activities, get around, and exercise. Having a problem with walking can make daily life more difficult. . The pattern of how you walk is called your gait. A variety of problems can cause an abnormal gait and lead to problems with walking. These include: . -Injuries, diseases, or abnormal development of the muscles or bones of your legs or feet. -Movement disorders such as Parkinson's disease. -Diseases such as arthritis or multiple sclerosis. -Vision or balance problems. Treatment of walking problems depends on the cause. Physical therapy, surgery, or mobility aids may help.  [from MedlinePlus]

MedGen UID:
86319
Concept ID:
C0311394
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