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Leucine

MedGen UID:
7312
Concept ID:
C0023401
Pharmacologic Substance
Synonyms: L-Isomer Leucine; L-Leucine; Leucine, L Isomer; Leucine, L-Isomer
SNOMED CT: Leucine (83797003); Leucine (412424004); L-Leucine (412425003); L-Leucine (83797003)
 

Definition

An essential branched-chain amino acid important for hemoglobin formation. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGLeucine

Recent clinical studies

Etiology

Verreijen AM, Verlaan S, Engberink MF, Swinkels S, de Vogel-van den Bosch J, Weijs PJ
Am J Clin Nutr 2015 Feb;101(2):279-86. Epub 2014 Nov 26 doi: 10.3945/ajcn.114.090290. [Epub ahead of print] PMID: 25646324
Dickinson JM, Gundermann DM, Walker DK, Reidy PT, Borack MS, Drummond MJ, Arora M, Volpi E, Rasmussen BB
J Nutr 2014 Nov;144(11):1694-702. Epub 2014 Sep 3 doi: 10.3945/jn.114.198671. [Epub ahead of print] PMID: 25332468Free PMC Article
Román E, Torrades MT, Nadal MJ, Cárdenas G, Nieto JC, Vidal S, Bascuñana H, Juárez C, Guarner C, Córdoba J, Soriano G
Dig Dis Sci 2014 Aug;59(8):1966-75. Epub 2014 Mar 6 doi: 10.1007/s10620-014-3086-6. [Epub ahead of print] PMID: 24599772
Bruckbauer A, Zemel MB
PLoS One 2014;9(2):e89166. Epub 2014 Feb 14 doi: 10.1371/journal.pone.0089166. PMID: 24551237Free PMC Article
Churchward-Venne TA, Breen L, Di Donato DM, Hector AJ, Mitchell CJ, Moore DR, Stellingwerff T, Breuille D, Offord EA, Baker SK, Phillips SM
Am J Clin Nutr 2014 Feb;99(2):276-86. Epub 2013 Nov 27 doi: 10.3945/ajcn.113.068775. [Epub ahead of print] PMID: 24284442

Diagnosis

Dickinson JM, Gundermann DM, Walker DK, Reidy PT, Borack MS, Drummond MJ, Arora M, Volpi E, Rasmussen BB
J Nutr 2014 Nov;144(11):1694-702. Epub 2014 Sep 3 doi: 10.3945/jn.114.198671. [Epub ahead of print] PMID: 25332468Free PMC Article
Xiang A, Lei X, Ren F, Zang L, Wang Q, Zhang J, Lu Z, Guo Y
Talanta 2014 Dec;130:363-9. Epub 2014 Jul 10 doi: 10.1016/j.talanta.2014.07.008. [Epub ahead of print] PMID: 25159422
Ni GX, Li Z, Zhou YZ
Osteoarthritis Cartilage 2014 Jul;22(7):896-903. Epub 2014 May 2 doi: 10.1016/j.joca.2014.04.026. [Epub ahead of print] PMID: 24795272
Labroo P, Cui Y
Anal Bioanal Chem 2014 Jan;406(1):367-72. Epub 2013 Nov 13 doi: 10.1007/s00216-013-7443-7. [Epub ahead of print] PMID: 24220759
Schriever SC, Deutsch MJ, Adamski J, Roscher AA, Ensenauer R
J Nutr Biochem 2013 May;24(5):824-31. Epub 2012 Aug 13 doi: 10.1016/j.jnutbio.2012.04.018. [Epub ahead of print] PMID: 22898570

Therapy

Lee P, Birzniece V, Umpleby AM, Poljak A, Ho KK
Metabolism 2015 Apr;64(4):506-12. Epub 2014 Dec 26 doi: 10.1016/j.metabol.2014.12.005. [Epub ahead of print] PMID: 25650070
Verreijen AM, Verlaan S, Engberink MF, Swinkels S, de Vogel-van den Bosch J, Weijs PJ
Am J Clin Nutr 2015 Feb;101(2):279-86. Epub 2014 Nov 26 doi: 10.3945/ajcn.114.090290. [Epub ahead of print] PMID: 25646324
Smith GI, Yoshino J, Stromsdorfer KL, Klein SJ, Magkos F, Reeds DN, Klein S, Mittendorfer B
Diabetes 2015 May;64(5):1555-63. Epub 2014 Dec 4 doi: 10.2337/db14-1279. [Epub ahead of print] PMID: 25475435Free PMC Article
Madeira MS, Pires VM, Alfaia CM, Luxton R, Doran O, Bessa RJ, Prates JA
Br J Nutr 2014 May;111(9):1521-35. Epub 2014 Feb 6 doi: 10.1017/S0007114513004029. [Epub ahead of print] PMID: 24502766
Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP
Clin Nutr 2014 Apr;33(2):211-20. Epub 2013 Jul 1 doi: 10.1016/j.clnu.2013.06.014. [Epub ahead of print] PMID: 23886411Free PMC Article

Prognosis

Dickinson JM, Gundermann DM, Walker DK, Reidy PT, Borack MS, Drummond MJ, Arora M, Volpi E, Rasmussen BB
J Nutr 2014 Nov;144(11):1694-702. Epub 2014 Sep 3 doi: 10.3945/jn.114.198671. [Epub ahead of print] PMID: 25332468Free PMC Article
Alqarni M, Myint KZ, Tong Q, Yang P, Bartlow P, Wang L, Feng R, Xie XQ
Biochem Biophys Res Commun 2014 Sep 26;452(3):334-9. Epub 2014 Aug 19 doi: 10.1016/j.bbrc.2014.08.048. [Epub ahead of print] PMID: 25148941Free PMC Article
Xi HQ, Cai AZ, Wu XS, Cui JX, Shen WS, Bian SB, Wang N, Li JY, Lu CR, Song Z, Wei B, Chen L
Br J Cancer 2014 Apr 15;110(8):2011-20. Epub 2014 Mar 4 doi: 10.1038/bjc.2014.112. [Epub ahead of print] PMID: 24594994Free PMC Article
Offord V, Werling D
Innate Immun 2013;19(4):398-402. Epub 2012 Nov 23 doi: 10.1177/1753425912465661. [Epub ahead of print] PMID: 23178228
Berglund M, Sunnåker M, Adiels M, Jirstrand M, Wennberg B
Math Med Biol 2012 Dec;29(4):361-84. Epub 2011 Sep 30 doi: 10.1093/imammb/dqr021. [Epub ahead of print] PMID: 21965323

Clinical prediction guides

Smith GI, Yoshino J, Stromsdorfer KL, Klein SJ, Magkos F, Reeds DN, Klein S, Mittendorfer B
Diabetes 2015 May;64(5):1555-63. Epub 2014 Dec 4 doi: 10.2337/db14-1279. [Epub ahead of print] PMID: 25475435Free PMC Article
Alqarni M, Myint KZ, Tong Q, Yang P, Bartlow P, Wang L, Feng R, Xie XQ
Biochem Biophys Res Commun 2014 Sep 26;452(3):334-9. Epub 2014 Aug 19 doi: 10.1016/j.bbrc.2014.08.048. [Epub ahead of print] PMID: 25148941Free PMC Article
Narla A, Payne EM, Abayasekara N, Hurst SN, Raiser DM, Look AT, Berliner N, Ebert BL, Khanna-Gupta A
Br J Haematol 2014 Nov;167(4):524-8. Epub 2014 Aug 7 doi: 10.1111/bjh.13069. [Epub ahead of print] PMID: 25098371Free PMC Article
Román E, Torrades MT, Nadal MJ, Cárdenas G, Nieto JC, Vidal S, Bascuñana H, Juárez C, Guarner C, Córdoba J, Soriano G
Dig Dis Sci 2014 Aug;59(8):1966-75. Epub 2014 Mar 6 doi: 10.1007/s10620-014-3086-6. [Epub ahead of print] PMID: 24599772
Luiking YC, Deutz NE, Memelink RG, Verlaan S, Wolfe RR
Nutr J 2014 Jan 22;13:9. doi: 10.1186/1475-2891-13-9. [Epub ahead of print] PMID: 24450500Free PMC Article

Recent systematic reviews

Li R, Zhao Y, Ye L
J Oral Rehabil 2014 Jun;41(6):432-42. Epub 2014 Mar 24 doi: 10.1111/joor.12161. [Epub ahead of print] PMID: 24661083
Kim YM, Kang M, Choi JH, Lee BH, Kim GH, Ohn JH, Kim SY, Park MS, Yoo HW
Metabolism 2014 Jan;63(1):42-9. Epub 2013 Oct 18 doi: 10.1016/j.metabol.2013.08.015. [Epub ahead of print] PMID: 24140098
You T, Lv J, Zhou L
DNA Cell Biol 2013 May;32(5):252-9. Epub 2013 Apr 16 doi: 10.1089/dna.2012.1961. [Epub ahead of print] PMID: 23590198
Zhang Y, Wang ZZ, Sun HM
Am J Med Genet B Neuropsychiatr Genet 2013 Apr;162B(3):235-44. Epub 2013 Feb 21 doi: 10.1002/ajmg.b.32138. [Epub ahead of print] PMID: 23436552
Lee YH, Choi SJ, Ji JD, Song GG
Lupus 2012 Jul;21(8):865-71. Epub 2012 Mar 7 doi: 10.1177/0961203312440348. [Epub ahead of print] PMID: 22399073

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