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African trypanosomiasis

MedGen UID:
21714
Concept ID:
C0041228
Disease or Syndrome
Synonyms: African Sleeping Sickness; African Sleeping Sicknesses; African Trypanosomiases; African Trypanosomiasis; Sickness, African Sleeping; Sicknesses, African Sleeping; Sleeping Sickness, African; Sleeping Sicknesses, African; Trypanosomiases, African; Trypanosomiasis, African
SNOMED CT: African trypanosomiasis (27031003); African sleeping sickness (27031003); Sleeping sickness (27031003); Sleeping sickness (78940002)
 
Orphanet: ORPHA3385

Definition

A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces "African sleeping sickness." Nagana is a rapidly fatal trypanosomiasis of horses and other animals. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAfrican trypanosomiasis
Follow this link to review classifications for African trypanosomiasis in Orphanet.

Recent clinical studies

Etiology

Sutherland CS, Yukich J, Goeree R, Tediosi F
PLoS Negl Trop Dis 2015 Feb;9(2):e0003397. Epub 2015 Feb 5 doi: 10.1371/journal.pntd.0003397. PMID: 25654605Free PMC Article
Muhanguzi D, Picozzi K, Hatendorf J, Thrusfield M, Welburn SC, Kabasa JD, Waiswa C
PLoS Negl Trop Dis 2014 Oct;8(10):e3284. Epub 2014 Oct 30 doi: 10.1371/journal.pntd.0003284. PMID: 25356758Free PMC Article
Sternberg JM, Mitchell JA
Trans R Soc Trop Med Hyg 2014 Jul;108(7):449-52. Epub 2014 Apr 30 doi: 10.1093/trstmh/tru065. [Epub ahead of print] PMID: 24789741Free PMC Article
Palmer JJ, Surur EI, Checchi F, Ahmad F, Ackom FK, Whitty CJ
PLoS Negl Trop Dis 2014 Mar;8(3):e2742. Epub 2014 Mar 20 doi: 10.1371/journal.pntd.0002742. PMID: 24651696Free PMC Article
Rashid K, Wachira FN, Nyariki JN, Isaac AO
Parasitol Int 2014 Apr;63(2):417-26. Epub 2014 Jan 15 doi: 10.1016/j.parint.2014.01.001. [Epub ahead of print] PMID: 24440762

Diagnosis

Büscher P, Deborggraeve S
Expert Rev Mol Diagn 2015 May;15(5):607-15. Epub 2015 Mar 18 doi: 10.1586/14737159.2015.1027195. [Epub ahead of print] PMID: 25786994
Steinmann P, Stone CM, Sutherland CS, Tanner M, Tediosi F
Trop Med Int Health 2015 Jun;20(6):707-18. Epub 2015 Mar 12 doi: 10.1111/tmi.12483. [Epub ahead of print] PMID: 25694261
Eperon G, Balasegaram M, Potet J, Mowbray C, Valverde O, Chappuis F
Expert Rev Anti Infect Ther 2014 Nov;12(11):1407-17. Epub 2014 Sep 10 doi: 10.1586/14787210.2014.959496. [Epub ahead of print] PMID: 25204360
Elliott I, Patel T, Shah J, Venkatesan P
BMJ Case Rep 2014 Aug 14;2014 doi: 10.1136/bcr-2014-204451. PMID: 25123570
Wengert O, Kopp M, Siebert E, Stenzel W, Hegasy G, Suttorp N, Stich A, Zoller T
Parasitol Int 2014 Jun;63(3):557-60. Epub 2014 Mar 5 doi: 10.1016/j.parint.2014.02.003. [Epub ahead of print] PMID: 24613272

Therapy

Sutherland CS, Yukich J, Goeree R, Tediosi F
PLoS Negl Trop Dis 2015 Feb;9(2):e0003397. Epub 2015 Feb 5 doi: 10.1371/journal.pntd.0003397. PMID: 25654605Free PMC Article
Muhanguzi D, Picozzi K, Hatendorf J, Thrusfield M, Welburn SC, Kabasa JD, Waiswa C
PLoS Negl Trop Dis 2014 Oct;8(10):e3284. Epub 2014 Oct 30 doi: 10.1371/journal.pntd.0003284. PMID: 25356758Free PMC Article
Eperon G, Balasegaram M, Potet J, Mowbray C, Valverde O, Chappuis F
Expert Rev Anti Infect Ther 2014 Nov;12(11):1407-17. Epub 2014 Sep 10 doi: 10.1586/14787210.2014.959496. [Epub ahead of print] PMID: 25204360
Wengert O, Kopp M, Siebert E, Stenzel W, Hegasy G, Suttorp N, Stich A, Zoller T
Parasitol Int 2014 Jun;63(3):557-60. Epub 2014 Mar 5 doi: 10.1016/j.parint.2014.02.003. [Epub ahead of print] PMID: 24613272
Rashid K, Wachira FN, Nyariki JN, Isaac AO
Parasitol Int 2014 Apr;63(2):417-26. Epub 2014 Jan 15 doi: 10.1016/j.parint.2014.01.001. [Epub ahead of print] PMID: 24440762

Prognosis

Rock KS, Stone CM, Hastings IM, Keeling MJ, Torr SJ, Chitnis N
Adv Parasitol 2015 Mar;87:53-133. Epub 2015 Feb 11 doi: 10.1016/bs.apar.2014.12.003. [Epub ahead of print] PMID: 25765194
Eperon G, Balasegaram M, Potet J, Mowbray C, Valverde O, Chappuis F
Expert Rev Anti Infect Ther 2014 Nov;12(11):1407-17. Epub 2014 Sep 10 doi: 10.1586/14787210.2014.959496. [Epub ahead of print] PMID: 25204360
Elliott I, Patel T, Shah J, Venkatesan P
BMJ Case Rep 2014 Aug 14;2014 doi: 10.1136/bcr-2014-204451. PMID: 25123570
Wring S, Gaukel E, Nare B, Jacobs R, Beaudet B, Bowling T, Mercer L, Bacchi C, Yarlett N, Randolph R, Parham R, Rewerts C, Platner J, Don R
Parasitology 2014 Jan;141(1):104-18. Epub 2013 Sep 5 doi: 10.1017/S003118201300098X. [Epub ahead of print] PMID: 24007596Free PMC Article
Mwanakasale V, Songolo P, Daka V
BMC Res Notes 2013 May 4;6:180. doi: 10.1186/1756-0500-6-180. [Epub ahead of print] PMID: 23642032Free PMC Article

Clinical prediction guides

Rock KS, Stone CM, Hastings IM, Keeling MJ, Torr SJ, Chitnis N
Adv Parasitol 2015 Mar;87:53-133. Epub 2015 Feb 11 doi: 10.1016/bs.apar.2014.12.003. [Epub ahead of print] PMID: 25765194
Sternberg JM, Gierliński M, Biéler S, Ferguson MA, Ndung'u JM
PLoS Negl Trop Dis 2014 Dec;8(12):e3373. Epub 2014 Dec 18 doi: 10.1371/journal.pntd.0003373. PMID: 25521120Free PMC Article
Palmer JJ, Surur EI, Checchi F, Ahmad F, Ackom FK, Whitty CJ
PLoS Negl Trop Dis 2014 Mar;8(3):e2742. Epub 2014 Mar 20 doi: 10.1371/journal.pntd.0002742. PMID: 24651696Free PMC Article
Lejon V, Mumba Ngoyi D, Kestens L, Boel L, Barbé B, Kande Betu V, van Griensven J, Bottieau E, Muyembe Tamfum JJ, Jacobs J, Büscher P
PLoS Pathog 2014 Mar;10(3):e1003947. Epub 2014 Mar 6 doi: 10.1371/journal.ppat.1003947. PMID: 24603894Free PMC Article
Wring S, Gaukel E, Nare B, Jacobs R, Beaudet B, Bowling T, Mercer L, Bacchi C, Yarlett N, Randolph R, Parham R, Rewerts C, Platner J, Don R
Parasitology 2014 Jan;141(1):104-18. Epub 2013 Sep 5 doi: 10.1017/S003118201300098X. [Epub ahead of print] PMID: 24007596Free PMC Article

Recent systematic reviews

Steinmann P, Stone CM, Sutherland CS, Tanner M, Tediosi F
Trop Med Int Health 2015 Jun;20(6):707-18. Epub 2015 Mar 12 doi: 10.1111/tmi.12483. [Epub ahead of print] PMID: 25694261
Sutherland CS, Yukich J, Goeree R, Tediosi F
PLoS Negl Trop Dis 2015 Feb;9(2):e0003397. Epub 2015 Feb 5 doi: 10.1371/journal.pntd.0003397. PMID: 25654605Free PMC Article
Neuberger A, Meltzer E, Leshem E, Dickstein Y, Stienlauf S, Schwartz E
PLoS One 2014;9(2):e88647. Epub 2014 Feb 19 doi: 10.1371/journal.pone.0088647. PMID: 24586363Free PMC Article
Lutje V, Seixas J, Kennedy A
Cochrane Database Syst Rev 2013 Jun 28;6:CD006201. doi: 10.1002/14651858.CD006201.pub3. PMID: 23807762
Mitashi P, Hasker E, Lejon V, Kande V, Muyembe JJ, Lutumba P, Boelaert M
PLoS Negl Trop Dis 2012;6(11):e1919. Epub 2012 Nov 29 doi: 10.1371/journal.pntd.0001919. PMID: 23209860Free PMC Article

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