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1.

Vaccines

Preparations containing substances with antigenic properties administered to activate the immune system, thereby inducing an immune response. Vaccines range from inactivated or attenuated microorganisms (bacteria and viruses), enhanced autologous tumor cells, tumor antigens or epitopes that are used to elicit host immune responses. Vaccines are used for the prevention, amelioration, or treatment of infectious diseases and cancer. [from NCI]

MedGen UID:
52963
Concept ID:
C0042210
Pharmacologic Substance
2.

Infection

Invasion of the host organism by microorganisms that can cause pathological conditions or diseases. [from MeSH]

MedGen UID:
811352
Concept ID:
C3714514
Pathologic Function
3.

Viral Shedding

The expelling of virus particles from the body. Important routes include the respiratory tract, genital tract, and intestinal tract. Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL). [from MeSH]

MedGen UID:
57951
Concept ID:
C0162633
Pathologic Function
4.

Infection

Unknown contamination with disease-producing germs. [from HHCC]

MedGen UID:
43874
Concept ID:
C0021311
Disease or Syndrome
5.

Disease

Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function. [from NCI]

MedGen UID:
4347
Concept ID:
C0012634
Disease or Syndrome
6.

Communicable Diseases

Infectious diseases kill more people worldwide than any other single cause. Infectious diseases are caused by germs. Germs are tiny living things that are found everywhere - in air, soil and water. You can get infected by touching, eating, drinking or breathing something that contains a germ. Germs can also spread through animal and insect bites, kissing and sexual contact. Vaccines, proper hand washing and medicines can help prevent infections. . There are four main kinds of germs: : - Bacteria - one-celled germs that multiply quickly and may release chemicals which can make you sick. - Viruses - capsules that contain genetic material, and use your own cells to multiply. - Fungi - primitive plants, like mushrooms or mildew . - Protozoa - one-celled animals that use other living things for food and a place to live. NIH: National Institute of Allergy and Infectious Diseases.  [from MedlinePlus]

MedGen UID:
1057
Concept ID:
C0009450
Disease or Syndrome
7.

disease

An alteration of health status resulting from a physiopathological mechanism, and having a homogeneous clinical presentation and evolution and homogeneous therapeutic possibilities. Excludes developmental anomalies. [from ORDO]

MedGen UID:
798428
Concept ID:
CN204926
Disease or Syndrome
8.

Live Attenuated Influenza Vaccine

A vaccine that contains live attenuated influenza virus (LAIV) particles. This vaccine is administered intranasally for influenza prophylaxis. Not all populations are good candidates for LAIV; the very young, elderly, asthmatics and those with health impaired may be better treated with the trivalent inactivated vaccine that is administered intramuscularly. [from NCI]

MedGen UID:
474390
Concept ID:
C3272757
Pharmacologic Substance
9.

Immunoglobulin A, Human

IgA is the immunoglobulin subclass that is associated with antibody-mediated mucosal immunity. It is secreted as dimers into the mucosa and is the most effective isotype at fixing complement by the alternative pathway, even though it lacks the ability to fix complement by the classical pathway. There are two subtypes in the human - IgA1 and IgA2. [from NCI]

MedGen UID:
442957
Concept ID:
C2825347
Pharmacologic Substance
10.

Severity

The degree of something undesirable e.g. pain or weather; also, strictness. [from NCI]

MedGen UID:
141003
Concept ID:
C0439793
11.

Immunoglobulin A

Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions. [from MeSH]

MedGen UID:
43820
Concept ID:
C0020835
Pharmacologic Substance
12.

Influenza

Flu is a respiratory infection caused by a number of viruses. The viruses pass through the air and enter your body through your nose or mouth. Between 5% and 20% of people in the U.S. get the flu each year. The flu can be serious or even deadly for elderly people, newborn babies, and people with certain chronic illnesses. Symptoms of the flu come on suddenly and are worse than those of the common cold. They may include: -Body or muscle aches. -Chills . -Cough . -Fever . -Headache . -Sore throat . Is it a cold or the flu? Colds rarely cause a fever or headaches. Flu almost never causes an upset stomach. And stomach flu isn't really flu at all, but gastroenteritis. Most people with the flu recover on their own without medical care. People with mild cases of the flu should stay home and avoid contact with others, except to get medical care. If you get the flu, your health care provider may prescribe medicine to help your body fight the infection and lessen symptoms. . The main way to keep from getting the flu is to get a yearly flu vaccine. Good hygiene, including hand washing, can also help. NIH: National Institute of Allergy and Infectious Diseases.  [from MedlinePlus]

MedGen UID:
9466
Concept ID:
C0021400
Disease or Syndrome
13.

Cross Protection

Protection conferred on a host by inoculation with one strain or component of a microorganism that prevents infection when later challenged with a similar strain. Most commonly the microorganism is a virus. [from MeSH]

MedGen UID:
403984
Concept ID:
C2717886
Molecular Function
14.

FluMist

MedGen UID:
270365
Concept ID:
C1311943
Pharmacologic Substance
15.

Immunoglobulins

there are two types of polypeptide chains responsible for the biological and immunological properties of the different immunoglobulins, the heavy chain and the light chain; they are linked by covalent and non-covalent forces to give a four-chain Y-shaped structure based on pairs of identical heavy and light chains; each chain consists of a variable region and a constant region which are coded for by different genes; some immunoglobulin classes occur as polymers of this basic monomer. [from CRISP]

MedGen UID:
43841
Concept ID:
C0021027
Pharmacologic Substance
16.

Viral vaccine

Any vaccine preparation composed of a live, attenuated, inactivated, killed or recombinant virus. Administration of a viral vaccine is to provide prophylaxis against viral disease or used as a vehicle to treat cancers. [from NCI]

MedGen UID:
22655
Concept ID:
C0042742
Pharmacologic Substance
17.

Vaccines, Synthetic

Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified. [from MeSH]

MedGen UID:
22601
Concept ID:
C0042213
Pharmacologic Substance
18.

Vaccines, Inactivated

Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins. [from MeSH]

MedGen UID:
12038
Concept ID:
C0042212
Pharmacologic Substance
19.

Vaccines, Attenuated

living microorganism, usually attenuated, administered to induce an immune response, containing a pathogen that either causes no or acceptable reactions, gives cross protection, or is the actual pathogen against which protection is wanted. [from CRISP]

MedGen UID:
12037
Concept ID:
C0042211
Pharmacologic Substance
20.

Artificial antigen

small synthetic peptides that mimic surface antigens of pathogens and are immunogenic. [from CRISP]

MedGen UID:
11692
Concept ID:
C0039115
Pharmacologic Substance

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