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Results: 1 to 20 of 55

1.

entecavir

A synthetic analog of 2-deoxyguanosine with antiviral activity against hepatitis B virus (HBV). Entecavir is activated in vivo to a 5-triphosphate metabolite. In turn, the triphosphate form competes with the natural substrate deoxyguanosine triphosphate (dGTP) for incorporation into viral DNA. The incorporation of the activated triphosphate metabolite of entecavir inhibits the reverse transcriptase (RT) viral RNA-dependent HBV DNA polymerase and, so, the replication of viral DNA and transcription. [from NCI]

MedGen UID:
201822
Concept ID:
C0971023
Pharmacologic Substance
2.

Type B viral hepatitis

Hepatitis B is one type of hepatitis - a liver disease- caused by the hepatitis B virus (HBV). Hepatitis B spreads by contact with an infected person's blood, semen or other body fluid. An infected woman can give hepatitis B to her baby at birth. If you get HBV, you may feel as if you have the flu, or you may have no symptoms at all. A blood test can tell if you have it. HBV usually gets better on its own after a few months. If it does not get better, it is called chronic HBV, which lasts a lifetime. Chronic HBV can lead to scarring of the liver, liver failure or liver cancer. There is a vaccine for HBV. It requires three shots. All babies should get the vaccine, but older children and adults can get it too. If you travel to countries where Hepatitis B is common, you should get the vaccine. NIH: National Institute of Diabetes and Digestive and Kidney Diseases.  [from MedlinePlus]

MedGen UID:
6807
Concept ID:
C0019163
Disease or Syndrome
3.

Inflammatory disease of liver

Your liver helps your body digest food, store energy and remove poisons. Hepatitis is a swelling of the liver that makes it stop working well. It can lead to scarring, called cirrhosis, or to cancer. Viruses cause most cases of hepatitis. The type of hepatitis is named for the virus that causes it; for example, hepatitis A, hepatitis B or hepatitis C. Drug or alcohol use can also lead to hepatitis. In other cases, your body mistakenly attacks its own tissues. You can help prevent some viral forms by getting a vaccine. Sometimes hepatitis goes away by itself. If it does not, it can be treated with drugs. Sometimes hepatitis lasts a lifetime. Some people who have hepatitis have no symptoms. Others may have: -Loss of appetite. -Nausea and vomiting. -Diarrhea. -Dark-colored urine and pale bowel movements. -Stomach pain. -Jaundice, yellowing of skin and eyes.  [from MedlinePlus]

MedGen UID:
5515
Concept ID:
C0019158
Disease or Syndrome
4.

Carcinoma

type of cancer [from CHV]

MedGen UID:
2867
Concept ID:
C0007097
Neoplastic Process
5.

Hepatitis

Inflammation of the liver. [from HPO]

MedGen UID:
506667
Concept ID:
CN167841
Finding
6.

Error occurred: cannot get document summary

ID:
430230

7.

Hepatocellular carcinoma

Hepatocellular carcinoma is the major histologic type of malignant primary liver neoplasm. It is the fifth most common cancer and the third most common cause of death from cancer worldwide. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. Hepatoblastomas comprise 1 to 2% of all malignant neoplasms of childhood, most often occurring in children under 3 years of age. Hepatoblastomas are thought to be derived from undifferentiated hepatocytes (Taniguchi et al., 2002). [from OMIM]

MedGen UID:
389187
Concept ID:
C2239176
Neoplastic Process
8.

Hepatocellular carcinoma

MedGen UID:
358104
Concept ID:
C1867955
Finding
9.

Recurrence (disease attribute)

The return of a sign, symptom, or disease after a remission. [from MeSH]

MedGen UID:
416712
Concept ID:
C2825055
Pathologic Function
10.

Cirrhosis

MedGen UID:
351476
Concept ID:
C1623038
Disease or Syndrome
11.

End stage liver disease

Final stage of a liver disease when the liver failure is irreversible and LIVER TRANSPLANTATION is needed. [from MeSH]

MedGen UID:
148174
Concept ID:
C0745744
Disease or Syndrome
12.

Hepatitis E

Acute INFLAMMATION of the LIVER in humans; caused by HEPATITIS E VIRUS, a non-enveloped single-stranded RNA virus. Similar to HEPATITIS A, its incubation period is 15-60 days and is enterically transmitted, usually by fecal-oral transmission. [from MeSH]

MedGen UID:
88376
Concept ID:
C0085293
Disease or Syndrome
13.

Disease

Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function. [from NCI]

MedGen UID:
4347
Concept ID:
C0012634
Disease or Syndrome
14.

disease

MedGen UID:
798428
Concept ID:
CN204926
Disease or Syndrome
15.

Related

MedGen UID:
619805
Concept ID:
C0445223
Finding
16.

Cirrhosis

A chronic disorder of the liver in which liver tissue becomes scarred and is partially replaced by regenerative nodules and fibrotic tissue resulting in loss of liver function. [from HPO]

MedGen UID:
504826
Concept ID:
CN001275
Finding
17.

Abnormality of the liver

An abnormality of the liver. [from HPO]

MedGen UID:
428258
Concept ID:
CN001274
Finding
18.

Disease Response

The pathologic and/or clinical changes that result from treatment. The changes may include eradication of detectable disease, stabilization of disease, or disease progression. [from NCI]

MedGen UID:
309976
Concept ID:
C1704632
Finding
19.

Chronic

A disease or condition that persists or progresses over a long period of time. [from NCI]

MedGen UID:
104657
Concept ID:
C0205191
20.

Chronic hepatitis

INFLAMMATION of the LIVER with ongoing hepatocellular injury for 6 months or more, characterized by NECROSIS of HEPATOCYTES and inflammatory cell (LEUKOCYTES) infiltration. Chronic hepatitis can be caused by viruses, medications, autoimmune diseases, and other unknown factors. [from MeSH]

MedGen UID:
9223
Concept ID:
C0019189
Disease or Syndrome

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