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Aging

MedGen UID:
1376
Concept ID:
C0001811
Synonyms: AGING
SNOMED CT: Aging (248280005)
 
OMIM: 502000

Definition

Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. This notion is supported by the observation of an aging-related accumulation in human mtDNA of oxidative and alkylation derivatives of nucleotides, of small deletions and insertions, and of large deletions, although their low frequency raises questions about their functional significance (Michikawa et al., 1999). [from OMIM]

Recent clinical studies

Etiology

Gureje O, Oladeji BD, Abiona T, Chatterji S
J Am Geriatr Soc 2014 May;62(5):836-42. Epub 2014 May 6 doi: 10.1111/jgs.12802. [Epub ahead of print] PMID: 24801657
Craciun C, Flick U
J Aging Stud 2014 Apr;29:78-87. Epub 2014 Feb 19 doi: 10.1016/j.jaging.2014.01.003. [Epub ahead of print] PMID: 24655675
Poon AH, Houseman EA, Ryan L, Sparrow D, Vokonas PS, Litonjua AA
J Gerontol A Biol Sci Med Sci 2014 Jul;69(7):907-13. Epub 2013 Nov 19 doi: 10.1093/gerona/glt179. [Epub ahead of print] PMID: 24253534Free PMC Article
Pathai S, Bajillan H, Landay AL, High KP
J Gerontol A Biol Sci Med Sci 2014 Jul;69(7):833-42. Epub 2013 Oct 24 doi: 10.1093/gerona/glt168. [Epub ahead of print] PMID: 24158766Free PMC Article
Glass AP, Vander Plaats RS
J Aging Stud 2013 Dec;27(4):428-42. Epub 2013 Nov 6 doi: 10.1016/j.jaging.2013.10.001. [Epub ahead of print] PMID: 24300063

Diagnosis

Drury SS, Shirtcliff EA, Shachet A, Phan J, Mabile E, Brett ZH, Wren M, Esteves K, Theall KP
Am J Med Sci 2014 Aug;348(2):92-100. doi: 10.1097/MAJ.0000000000000299. PMID: 25010187Free PMC Article
Zhang K, Xu B, Liu DF, Wang XF, Zhu JC, Jin J, Jiang H
Asian J Androl 2014 Jan-Feb;16(1):153-6. doi: 10.4103/1008-682X.122580. PMID: 24369150Free PMC Article
Thibault O, Anderson KL, DeMoll C, Brewer LD, Landfield PW, Porter NM
Eur J Pharmacol 2013 Nov 5;719(1-3):34-43. Epub 2013 Jul 17 doi: 10.1016/j.ejphar.2013.07.024. [Epub ahead of print] PMID: 23872402Free PMC Article
Scheibye-Knudsen M, Scheibye-Alsing K, Canugovi C, Croteau DL, Bohr VA
Aging (Albany NY) 2013 Mar;5(3):192-208. PMID: 23524341Free PMC Article
Menendez JA, Joven J
Aging (Albany NY) 2012 Dec;4(12):894-8. PMID: 23525940Free PMC Article

Therapy

Gureje O, Oladeji BD, Abiona T, Chatterji S
J Am Geriatr Soc 2014 May;62(5):836-42. Epub 2014 May 6 doi: 10.1111/jgs.12802. [Epub ahead of print] PMID: 24801657
Selman M, Pardo A
Am J Respir Crit Care Med 2014 May 15;189(10):1161-72. doi: 10.1164/rccm.201312-2221PP. PMID: 24641682
Zhang K, Xu B, Liu DF, Wang XF, Zhu JC, Jin J, Jiang H
Asian J Androl 2014 Jan-Feb;16(1):153-6. doi: 10.4103/1008-682X.122580. PMID: 24369150Free PMC Article
Poon AH, Houseman EA, Ryan L, Sparrow D, Vokonas PS, Litonjua AA
J Gerontol A Biol Sci Med Sci 2014 Jul;69(7):907-13. Epub 2013 Nov 19 doi: 10.1093/gerona/glt179. [Epub ahead of print] PMID: 24253534Free PMC Article
Blagosklonny MV
Aging (Albany NY) 2012 Dec;4(12):861-77. PMID: 23425777Free PMC Article

Prognosis

Gureje O, Oladeji BD, Abiona T, Chatterji S
J Am Geriatr Soc 2014 May;62(5):836-42. Epub 2014 May 6 doi: 10.1111/jgs.12802. [Epub ahead of print] PMID: 24801657
Selman M, Pardo A
Am J Respir Crit Care Med 2014 May 15;189(10):1161-72. doi: 10.1164/rccm.201312-2221PP. PMID: 24641682
Schuck NW, Frensch PA, Schjeide BM, Schröder J, Bertram L, Li SC
Neuropsychologia 2013 Nov;51(13):2757-69. Epub 2013 Sep 12 doi: 10.1016/j.neuropsychologia.2013.09.009. [Epub ahead of print] PMID: 24035787
Valdés Hernández Mdel C, Booth T, Murray C, Gow AJ, Penke L, Morris Z, Maniega SM, Royle NA, Aribisala BS, Bastin ME, Starr JM, Deary IJ, Wardlaw JM
Neurobiol Aging 2013 Dec;34(12):2740-7. Epub 2013 Jul 11 doi: 10.1016/j.neurobiolaging.2013.05.032. [Epub ahead of print] PMID: 23850341Free PMC Article
Blagosklonny MV
Aging (Albany NY) 2012 Dec;4(12):861-77. PMID: 23425777Free PMC Article

Clinical prediction guides

Gureje O, Oladeji BD, Abiona T, Chatterji S
J Am Geriatr Soc 2014 May;62(5):836-42. Epub 2014 May 6 doi: 10.1111/jgs.12802. [Epub ahead of print] PMID: 24801657
Akasaki Y, Hasegawa A, Saito M, Asahara H, Iwamoto Y, Lotz MK
Osteoarthritis Cartilage 2014 Jan;22(1):162-70. Epub 2013 Nov 21 doi: 10.1016/j.joca.2013.11.004. [Epub ahead of print] PMID: 24269635Free PMC Article
Valdés Hernández Mdel C, Booth T, Murray C, Gow AJ, Penke L, Morris Z, Maniega SM, Royle NA, Aribisala BS, Bastin ME, Starr JM, Deary IJ, Wardlaw JM
Neurobiol Aging 2013 Dec;34(12):2740-7. Epub 2013 Jul 11 doi: 10.1016/j.neurobiolaging.2013.05.032. [Epub ahead of print] PMID: 23850341Free PMC Article
Kohler J, Popov C, Klotz B, Alberton P, Prall WC, Haasters F, Müller-Deubert S, Ebert R, Klein-Hitpass L, Jakob F, Schieker M, Docheva D
Aging Cell 2013 Dec;12(6):988-99. Epub 2013 Jul 22 doi: 10.1111/acel.12124. [Epub ahead of print] PMID: 23826660
Blagosklonny MV
Aging (Albany NY) 2012 Dec;4(12):861-77. PMID: 23425777Free PMC Article

Recent systematic reviews

Selman M, Pardo A
Am J Respir Crit Care Med 2014 May 15;189(10):1161-72. doi: 10.1164/rccm.201312-2221PP. PMID: 24641682
Pathai S, Bajillan H, Landay AL, High KP
J Gerontol A Biol Sci Med Sci 2014 Jul;69(7):833-42. Epub 2013 Oct 24 doi: 10.1093/gerona/glt168. [Epub ahead of print] PMID: 24158766Free PMC Article
Momtaz YA, Hamid TA, Masud J, Haron SA, Ibrahim R
Clin Interv Aging 2013;8:1413-20. Epub 2013 Oct 21 doi: 10.2147/CIA.S51877. PMID: 24174873Free PMC Article
García-Prat L, Sousa-Victor P, Muñoz-Cánoves P
FEBS J 2013 Sep;280(17):4051-62. Epub 2013 Mar 21 doi: 10.1111/febs.12221. [Epub ahead of print] PMID: 23452120
Jeste DV, Savla GN, Thompson WK, Vahia IV, Glorioso DK, Martin AS, Palmer BW, Rock D, Golshan S, Kraemer HC, Depp CA
Am J Psychiatry 2013 Feb 1;170(2):188-96. doi: 10.1176/appi.ajp.2012.12030386. PMID: 23223917Free PMC Article

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