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Stillbirth

MedGen UID:
154536
Concept ID:
C0595939
Finding
Synonyms: Fetal death; Stillborn
SNOMED CT: SB - Stillbirth (237364002); Stillbirth (237364002)
 
HPO: HP:0003826

Definition

If a woman loses a pregnancy after she's past her 20th week, it's called a stillbirth. Stillbirths are due to natural causes. They can happen before delivery or during delivery. Causes include:: -Problems with the placenta, the organ that transports oxygen and nutrients to the fetus. -Genetic problems with the fetus. -Fetal infections. -Other physical problems in the fetus. In at least half of all cases, it is not possible to tell why the baby died. If stillbirth happens before delivery, your health care provider may induce labor or perform a Cesarean section to deliver the fetus. In some cases, you can wait until you go into labor yourself. This usually happens within two weeks of stillbirth. Counseling may help you cope with your grief. Later, if you do decide to try again, work closely with your health care provider to lower the risks. Many women who have a stillbirth go on to have healthy babies. NIH: National Institute of Child Health and Human Development.  [from MedlinePlus]

Recent clinical studies

Etiology

Pariente G, Shoham-Vardi I, Kessous R, Sergienko R, Sheiner E
Am J Obstet Gynecol 2014 Oct;211(4):416.e1-12. Epub 2014 Jul 25 doi: 10.1016/j.ajog.2014.07.032. [Epub ahead of print] PMID: 25068554
Wood S, Tang S, Ross S, Sauve R
BJOG 2014 Sep;121(10):1284-90; discussion 1291. Epub 2014 May 29 doi: 10.1111/1471-0528.12866. [Epub ahead of print] PMID: 24888505
Zhang X, Kramer MS
BJOG 2014 Sep;121(10):1229-36. Epub 2014 May 27 doi: 10.1111/1471-0528.12883. [Epub ahead of print] PMID: 24861638
Yao R, Ananth CV, Park BY, Pereira L, Plante LA; Perinatal Research Consortium
Am J Obstet Gynecol 2014 May;210(5):457.e1-9. Epub 2014 Mar 25 doi: 10.1016/j.ajog.2014.01.044. [Epub ahead of print] PMID: 24674712
Silver RM, Parker CB, Goldenberg R, Reddy UM, Dudley DJ, Saade GR, Hogue CJ, Coustan D, Varner MW, Koch MA, Conway D, Bukowski R, Pinar H, Stoll B, Moore J, Willinger M
Am J Obstet Gynecol 2014 May;210(5):460.e1-9. Epub 2013 Nov 8 doi: 10.1016/j.ajog.2013.11.017. [Epub ahead of print] PMID: 24215860

Diagnosis

Wood S, Tang S, Ross S, Sauve R
BJOG 2014 Sep;121(10):1284-90; discussion 1291. Epub 2014 May 29 doi: 10.1111/1471-0528.12866. [Epub ahead of print] PMID: 24888505
Bukowski R, Hansen NI, Willinger M, Reddy UM, Parker CB, Pinar H, Silver RM, Dudley DJ, Stoll BJ, Saade GR, Koch MA, Rowland Hogue CJ, Varner MW, Conway DL, Coustan D, Goldenberg RL; Eunice Kennedy Shriver National Institute of Child Health and Human Development Stillbirth Collaborative Research Network
PLoS Med 2014 Apr;11(4):e1001633. Epub 2014 Apr 22 doi: 10.1371/journal.pmed.1001633. PMID: 24755550Free PMC Article
Endler M, Saltvedt S, Cnattingius S, Stephansson O, Wikström AK
BJOG 2014 Nov;121(12):1462-70. Epub 2014 Apr 7 doi: 10.1111/1471-0528.12752. [Epub ahead of print] PMID: 24703089
Silver RM, Parker CB, Goldenberg R, Reddy UM, Dudley DJ, Saade GR, Hogue CJ, Coustan D, Varner MW, Koch MA, Conway D, Bukowski R, Pinar H, Stoll B, Moore J, Willinger M
Am J Obstet Gynecol 2014 May;210(5):460.e1-9. Epub 2013 Nov 8 doi: 10.1016/j.ajog.2013.11.017. [Epub ahead of print] PMID: 24215860
Stormdal Bring H, Hulthén Varli IA, Kublickas M, Papadogiannakis N, Pettersson K
Acta Obstet Gynecol Scand 2014 Jan;93(1):86-92. Epub 2013 Nov 7 doi: 10.1111/aogs.12278. [Epub ahead of print] PMID: 24117104

Therapy

Wood S, Tang S, Ross S, Sauve R
BJOG 2014 Sep;121(10):1284-90; discussion 1291. Epub 2014 May 29 doi: 10.1111/1471-0528.12866. [Epub ahead of print] PMID: 24888505
Zhang X, Kramer MS
BJOG 2014 Sep;121(10):1229-36. Epub 2014 May 27 doi: 10.1111/1471-0528.12883. [Epub ahead of print] PMID: 24861638
Henningsen AA, Wennerholm UB, Gissler M, Romundstad LB, Nygren KG, Tiitinen A, Skjaerven R, Nyboe Andersen A, Lidegaard Ø, Forman JL, Pinborg A
Hum Reprod 2014 May;29(5):1090-6. Epub 2014 Feb 26 doi: 10.1093/humrep/deu031. [Epub ahead of print] PMID: 24578477
Varner MW, Silver RM, Rowland Hogue CJ, Willinger M, Parker CB, Thorsten VR, Goldenberg RL, Saade GR, Dudley DJ, Coustan D, Stoll B, Bukowski R, Koch MA, Conway D, Pinar H, Reddy UM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Stillbirth Collaborative Research Network
Obstet Gynecol 2014 Jan;123(1):113-25. doi: 10.1097/AOG.0000000000000052. PMID: 24463671Free PMC Article
Silver RM, Parker CB, Goldenberg R, Reddy UM, Dudley DJ, Saade GR, Hogue CJ, Coustan D, Varner MW, Koch MA, Conway D, Bukowski R, Pinar H, Stoll B, Moore J, Willinger M
Am J Obstet Gynecol 2014 May;210(5):460.e1-9. Epub 2013 Nov 8 doi: 10.1016/j.ajog.2013.11.017. [Epub ahead of print] PMID: 24215860

Prognosis

Aminu M, Unkels R, Mdegela M, Utz B, Adaji S, van den Broek N
BJOG 2014 Sep;121 Suppl 4:141-53. doi: 10.1111/1471-0528.12995. PMID: 25236649
Pariente G, Shoham-Vardi I, Kessous R, Sergienko R, Sheiner E
Am J Obstet Gynecol 2014 Oct;211(4):416.e1-12. Epub 2014 Jul 25 doi: 10.1016/j.ajog.2014.07.032. [Epub ahead of print] PMID: 25068554
Frey HA, Odibo AO, Dicke JM, Shanks AL, Macones GA, Cahill AG
Obstet Gynecol 2014 Jul;124(1):91-8. doi: 10.1097/AOG.0000000000000335. PMID: 24901272Free PMC Article
Wood S, Tang S, Ross S, Sauve R
BJOG 2014 Sep;121(10):1284-90; discussion 1291. Epub 2014 May 29 doi: 10.1111/1471-0528.12866. [Epub ahead of print] PMID: 24888505
Trudell AS, Tuuli MG, Cahill AG, Macones GA, Odibo AO
Am J Obstet Gynecol 2014 Sep;211(3):295.e1-7. Epub 2014 Apr 15 doi: 10.1016/j.ajog.2014.04.021. [Epub ahead of print] PMID: 24746999Free PMC Article

Clinical prediction guides

Mone F, Meti S, Ong S
Ir Med J 2014 Jun;107(6):181-3. PMID: 24988838
Zhang X, Kramer MS
BJOG 2014 Sep;121(10):1229-36. Epub 2014 May 27 doi: 10.1111/1471-0528.12883. [Epub ahead of print] PMID: 24861638
Henningsen AA, Wennerholm UB, Gissler M, Romundstad LB, Nygren KG, Tiitinen A, Skjaerven R, Nyboe Andersen A, Lidegaard Ø, Forman JL, Pinborg A
Hum Reprod 2014 May;29(5):1090-6. Epub 2014 Feb 26 doi: 10.1093/humrep/deu031. [Epub ahead of print] PMID: 24578477
Heuser CC, McFadden M, Hammer A, Varner MW, Silver RM
Am J Perinatol 2014 May;31(5):393-400. Epub 2013 Aug 5 doi: 10.1055/s-0033-1349344. [Epub ahead of print] PMID: 23918519
Likis FE, Sathe NA, Carnahan R, McPheeters ML
Vaccine 2013 Dec 30;31 Suppl 10:K74-82. doi: 10.1016/j.vaccine.2013.03.076. PMID: 24331077

Recent systematic reviews

Aminu M, Unkels R, Mdegela M, Utz B, Adaji S, van den Broek N
BJOG 2014 Sep;121 Suppl 4:141-53. doi: 10.1111/1471-0528.12995. PMID: 25236649
Aune D, Saugstad OD, Henriksen T, Tonstad S
JAMA 2014 Apr 16;311(15):1536-46. doi: 10.1001/jama.2014.2269. PMID: 24737366
Likis FE, Sathe NA, Carnahan R, McPheeters ML
Vaccine 2013 Dec 30;31 Suppl 10:K74-82. doi: 10.1016/j.vaccine.2013.03.076. PMID: 24331077
Derricott H, Jones RL, Heazell AE
Placenta 2013 Oct;34(10):856-62. Epub 2013 Jul 30 doi: 10.1016/j.placenta.2013.07.003. [Epub ahead of print] PMID: 23906543
Danon D, Sekar R, Hack KE, Fisk NM
Obstet Gynecol 2013 Jun;121(6):1318-26. doi: 10.1097/AOG.0b013e318292766b. PMID: 23812469

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